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The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population.
Nutr Metab Cardiovasc Dis. 2007 Mar; 17(3):224-9.NM

Abstract

Our goal was to determine whether the presence of the -516C/T polymorphism in the APOB gene promoter modifies the lipid response to changes in the amount and quality of dietary fat. We studied 97 young healthy volunteers (70 males and 27 females), 62 homozygotes for the -516C allele (C/C) (47 males and 15 females), 34 heterozygotes for the -516T allele (C/T) (22 males and 12 females) and one male homozygote for the -516T allele (T/T). Subjects consumed three different diets in successive 4-week dietary periods. During the first 28 days, all subjects consumed a saturated fatty acid (SFA)-rich diet (38% fat and 20% SFA). Then, using a randomized crossover design, subjects were assigned a carbohydrate (CHO)-rich diet (30% fat and 55% carbohydrate) or a monounsaturated fatty acid (MUFA)-rich diet (38% fat and 22% MUFA). At the end of each dietary period, plasma concentrations of triacylglycerols and of total, LDL, and HDL cholesterol were measured. No differences in plasma lipid and apolipoprotein response were found after changes in dietary fat intake in relation to the -516C/T polymorphism in our study population. In conclusion, our data suggest that the APOB -516C/T polymorphism has no effect on the lipid profile after changes in dietary fat intake in a healthy population.

Authors+Show Affiliations

Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Avda Menendez Pidal, s/n. 14004 Cordoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17367707

Citation

Perez-Martinez, Pablo, et al. "The APOB -516C/T Polymorphism Has No Effect On Lipid and Apolipoprotein Response Following Changes in Dietary Fat Intake in a Healthy Population." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 17, no. 3, 2007, pp. 224-9.
Perez-Martinez P, Perez-Jimenez F, Ordovas JM, et al. The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population. Nutr Metab Cardiovasc Dis. 2007;17(3):224-9.
Perez-Martinez, P., Perez-Jimenez, F., Ordovas, J. M., Bellido, C., Moreno, J. A., Gomez, P., Marin, C., Fernandez de la Puebla, R. A., Paniagua, J. A., & Lopez-Miranda, J. (2007). The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 17(3), 224-9.
Perez-Martinez P, et al. The APOB -516C/T Polymorphism Has No Effect On Lipid and Apolipoprotein Response Following Changes in Dietary Fat Intake in a Healthy Population. Nutr Metab Cardiovasc Dis. 2007;17(3):224-9. PubMed PMID: 17367707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population. AU - Perez-Martinez,Pablo, AU - Perez-Jimenez,Francisco, AU - Ordovas,Jose M, AU - Bellido,Cecilia, AU - Moreno,Juan A, AU - Gomez,Purificación, AU - Marin,Carmen, AU - Fernandez de la Puebla,Rafael Angel, AU - Paniagua,Juan Antonio, AU - Lopez-Miranda,Jose, Y1 - 2006/03/20/ PY - 2005/05/02/received PY - 2005/11/02/revised PY - 2005/11/02/accepted PY - 2007/3/21/pubmed PY - 2007/4/12/medline PY - 2007/3/21/entrez SP - 224 EP - 9 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 17 IS - 3 N2 - Our goal was to determine whether the presence of the -516C/T polymorphism in the APOB gene promoter modifies the lipid response to changes in the amount and quality of dietary fat. We studied 97 young healthy volunteers (70 males and 27 females), 62 homozygotes for the -516C allele (C/C) (47 males and 15 females), 34 heterozygotes for the -516T allele (C/T) (22 males and 12 females) and one male homozygote for the -516T allele (T/T). Subjects consumed three different diets in successive 4-week dietary periods. During the first 28 days, all subjects consumed a saturated fatty acid (SFA)-rich diet (38% fat and 20% SFA). Then, using a randomized crossover design, subjects were assigned a carbohydrate (CHO)-rich diet (30% fat and 55% carbohydrate) or a monounsaturated fatty acid (MUFA)-rich diet (38% fat and 22% MUFA). At the end of each dietary period, plasma concentrations of triacylglycerols and of total, LDL, and HDL cholesterol were measured. No differences in plasma lipid and apolipoprotein response were found after changes in dietary fat intake in relation to the -516C/T polymorphism in our study population. In conclusion, our data suggest that the APOB -516C/T polymorphism has no effect on the lipid profile after changes in dietary fat intake in a healthy population. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17367707/The_APOB__516C/T_polymorphism_has_no_effect_on_lipid_and_apolipoprotein_response_following_changes_in_dietary_fat_intake_in_a_healthy_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(05)00254-1 DB - PRIME DP - Unbound Medicine ER -