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Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania.

Abstract

Some studies suggest that mitochondrial dysfunction may be related to the pathophysiology of bipolar disorder. In this work, we evaluated the activity of citrate synthase in rats, and the effects of the treatment with mood stabilizers (lithium and valproate) on the enzyme activity. In the first experiment (reversal treatment), amphetamine or saline were administered to rats for 14 days, and between day 8 and 14, rats were treated with either lithium, valproate or saline. In the second experiment (prevention treatment), rats were pretreated with lithium, valproate or saline, and between day 8 and 14, rats were administered amphetamine or saline. In reversal and prevention models, amphetamine administration significantly inhibited citrate synthase activity in rat hippocampus. In amphetamine-pretreated animals, valproate administration reversed citrate synthase activity inhibition induced by amphetamine. In the prevention model, pretreatment with lithium prevented amphetamine-induced citrate synthase inhibition. Our results showed that amphetamine inhibited citrate synthase activity and that valproate reversed and lithium prevented the enzyme inhibition.

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  • Authors+Show Affiliations

    ,

    Laboratório de Fisiopatologia Experimental, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.

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    Source

    MeSH

    Amphetamine
    Analysis of Variance
    Animals
    Antimanic Agents
    Bipolar Disorder
    Citrate (si)-Synthase
    Disease Models, Animal
    Drug Interactions
    Hippocampus
    Lithium Chloride
    Male
    Rats
    Rats, Wistar
    Valproic Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17367908

    Citation

    Corrêa, Cristiane, et al. "Effects of Lithium and Valproate On Hippocampus Citrate Synthase Activity in an Animal Model of Mania." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 31, no. 4, 2007, pp. 887-91.
    Corrêa C, Amboni G, Assis LC, et al. Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(4):887-91.
    Corrêa, C., Amboni, G., Assis, L. C., Martins, M. R., Kapczinski, F., Streck, E. L., & Quevedo, J. (2007). Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. Progress in Neuro-psychopharmacology & Biological Psychiatry, 31(4), pp. 887-91.
    Corrêa C, et al. Effects of Lithium and Valproate On Hippocampus Citrate Synthase Activity in an Animal Model of Mania. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):887-91. PubMed PMID: 17367908.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. AU - Corrêa,Cristiane, AU - Amboni,Graziela, AU - Assis,Lara Clemes, AU - Martins,Márcio R, AU - Kapczinski,Flávio, AU - Streck,Emilio L, AU - Quevedo,João, Y1 - 2007/02/15/ PY - 2006/09/12/received PY - 2007/02/06/revised PY - 2007/02/06/accepted PY - 2007/3/21/pubmed PY - 2007/8/4/medline PY - 2007/3/21/entrez SP - 887 EP - 91 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 31 IS - 4 N2 - Some studies suggest that mitochondrial dysfunction may be related to the pathophysiology of bipolar disorder. In this work, we evaluated the activity of citrate synthase in rats, and the effects of the treatment with mood stabilizers (lithium and valproate) on the enzyme activity. In the first experiment (reversal treatment), amphetamine or saline were administered to rats for 14 days, and between day 8 and 14, rats were treated with either lithium, valproate or saline. In the second experiment (prevention treatment), rats were pretreated with lithium, valproate or saline, and between day 8 and 14, rats were administered amphetamine or saline. In reversal and prevention models, amphetamine administration significantly inhibited citrate synthase activity in rat hippocampus. In amphetamine-pretreated animals, valproate administration reversed citrate synthase activity inhibition induced by amphetamine. In the prevention model, pretreatment with lithium prevented amphetamine-induced citrate synthase inhibition. Our results showed that amphetamine inhibited citrate synthase activity and that valproate reversed and lithium prevented the enzyme inhibition. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17367908/Effects_of_lithium_and_valproate_on_hippocampus_citrate_synthase_activity_in_an_animal_model_of_mania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00064-4 DB - PRIME DP - Unbound Medicine ER -