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Ethnic difference in periodic limb movements in children.
Sleep Med. 2007 Apr; 8(3):240-6.SM

Abstract

BACKGROUND

Epidemiological studies have suggested that ethnicity is a risk factor for sleep-disordered breathing (SDB) and that African-American children are three times more likely than Caucasian children to have SDB. Ethnic differences in sleep architecture and other routinely assessed sleep parameters have not been critically assessed, thus the aim of this study was to compare sleep characteristics in African-American and Caucasian children.

METHODS

A total of 41,363 sleep questionnaires were mailed to parents of children aged 5-7 years in Jefferson County, KY. Parents of snoring and non-snoring children were invited to have their child undergo overnight polysomnography.

RESULTS

Complete questionnaires were returned by 9872 families (23% response rate). Of these, 689 agreed to undergo polysomnography, and 542 complete polysomnograms were obtained (5.7% of questionnaire respondents). There were 391 Caucasian and 151 African-American children with a mean age of 6.7+/-0.5 years who underwent overnight polysomnographic evaluation. No differences between groups were observed for sleep latency, total sleep time, sleep efficiency, or rapid eye movement (REM) latency. African-American children had slightly increased stage 3 sleep (6.0+/-2.8% vs. 5.4+/-2.8%; p=0.01), although the total proportion of slow wave sleep was similar. Higher respiratory arousal index (3.6+/-6.5/h vs. 1.4+/-2.7/h; p<0.001) and total arousal index (11.5+/-5.2/h vs. 9.8+/-4.8/h; p<0.001) emerged in African-American children, who were more likely to have mild SDB (AHI>1:34% in African-American vs. 24% in Caucasian; p=0.017) and SDB (AHI>5: 22.5% vs. 7%; p<0.001). However, Caucasian children were more likely to have periodic leg movements during sleep (PLMS; 16.5% vs. 7% in AA; p=0.004). The odds ratio for a Caucasian child to have PLMS was 2.6 (95% confidence interval (CI) 1.3-5.3; p=0.006). Furthermore, in the absence of SDB, the odds ratio for a Caucasian child to have PLMS was 9.5 (95% CI: 2.2-39.9; p=0.002).

CONCLUSIONS

African-American and Caucasian children have similar sleep architecture. African-American children are more likely to display respiratory disturbances during sleep, while PLMS are significantly more prevalent among Caucasian children.

Authors+Show Affiliations

Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, Louisville, KY 40202, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17368099

Citation

O'Brien, Louise M., et al. "Ethnic Difference in Periodic Limb Movements in Children." Sleep Medicine, vol. 8, no. 3, 2007, pp. 240-6.
O'Brien LM, Holbrook CR, Faye Jones V, et al. Ethnic difference in periodic limb movements in children. Sleep Med. 2007;8(3):240-6.
O'Brien, L. M., Holbrook, C. R., Faye Jones, V., & Gozal, D. (2007). Ethnic difference in periodic limb movements in children. Sleep Medicine, 8(3), 240-6.
O'Brien LM, et al. Ethnic Difference in Periodic Limb Movements in Children. Sleep Med. 2007;8(3):240-6. PubMed PMID: 17368099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnic difference in periodic limb movements in children. AU - O'Brien,Louise M, AU - Holbrook,Cheryl R, AU - Faye Jones,V, AU - Gozal,David, Y1 - 2007/03/23/ PY - 2006/01/22/received PY - 2006/08/07/revised PY - 2006/08/14/accepted PY - 2007/3/21/pubmed PY - 2007/8/19/medline PY - 2007/3/21/entrez SP - 240 EP - 6 JF - Sleep medicine JO - Sleep Med VL - 8 IS - 3 N2 - BACKGROUND: Epidemiological studies have suggested that ethnicity is a risk factor for sleep-disordered breathing (SDB) and that African-American children are three times more likely than Caucasian children to have SDB. Ethnic differences in sleep architecture and other routinely assessed sleep parameters have not been critically assessed, thus the aim of this study was to compare sleep characteristics in African-American and Caucasian children. METHODS: A total of 41,363 sleep questionnaires were mailed to parents of children aged 5-7 years in Jefferson County, KY. Parents of snoring and non-snoring children were invited to have their child undergo overnight polysomnography. RESULTS: Complete questionnaires were returned by 9872 families (23% response rate). Of these, 689 agreed to undergo polysomnography, and 542 complete polysomnograms were obtained (5.7% of questionnaire respondents). There were 391 Caucasian and 151 African-American children with a mean age of 6.7+/-0.5 years who underwent overnight polysomnographic evaluation. No differences between groups were observed for sleep latency, total sleep time, sleep efficiency, or rapid eye movement (REM) latency. African-American children had slightly increased stage 3 sleep (6.0+/-2.8% vs. 5.4+/-2.8%; p=0.01), although the total proportion of slow wave sleep was similar. Higher respiratory arousal index (3.6+/-6.5/h vs. 1.4+/-2.7/h; p<0.001) and total arousal index (11.5+/-5.2/h vs. 9.8+/-4.8/h; p<0.001) emerged in African-American children, who were more likely to have mild SDB (AHI>1:34% in African-American vs. 24% in Caucasian; p=0.017) and SDB (AHI>5: 22.5% vs. 7%; p<0.001). However, Caucasian children were more likely to have periodic leg movements during sleep (PLMS; 16.5% vs. 7% in AA; p=0.004). The odds ratio for a Caucasian child to have PLMS was 2.6 (95% confidence interval (CI) 1.3-5.3; p=0.006). Furthermore, in the absence of SDB, the odds ratio for a Caucasian child to have PLMS was 9.5 (95% CI: 2.2-39.9; p=0.002). CONCLUSIONS: African-American and Caucasian children have similar sleep architecture. African-American children are more likely to display respiratory disturbances during sleep, while PLMS are significantly more prevalent among Caucasian children. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/17368099/Ethnic_difference_in_periodic_limb_movements_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(06)00581-8 DB - PRIME DP - Unbound Medicine ER -