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Isoflavone-supplemented soy yoghurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats.
Maturitas 2007; 57(3):261-70M

Abstract

OBJECTIVE

To determine the effects produced by the ingestion of a fermented soy product (soy yoghurt), supplemented with isoflavones and associated with a resistive exercise program, on the bone metabolism of mature ovariectomized (Ovx) and sham-ovariectomized (sham-Ovx) rats.

METHODS

A total of 56 rats were used. They were divided into 2 sedentary control groups, the Ovx control group (C-Ovx) and the sham-Ovx control group (C-Sovx), each with 7 sedentary animals, and 2 treated groups, Ovx and sham-Ovx, with 21 animals each. These two treated groups were subdivided into three subgroups of seven animals each, which received the following treatments: consuming the soy yoghurt+sedentary, only subjected to resistive exercise, and consuming the soy yoghurt+resistive exercise. Both the program of resistive exercise and the consumption of soy yoghurt (at 3 mL/(kg body weight day)) continued for 12 weeks. The soy yoghurt was supplemented with isoflavones at 50mg/100g of product. The animals were sacrificed and their right-side femurs and tibias removed and assessed for bone mineral density (BMD). The alkaline phosphatase activity (AP) was determined in the blood serum.

RESULTS

There was a significant increase in both femur and tibia BMD values and in serum alkaline phosphatase activity in all the treated subgroups, compared with the control groups (p<0.05).

CONCLUSION

The ingestion of the soy yoghurt supplemented with isoflavones was capable of preventing a loss of bone mass in Ovx rats and of increasing bone mass in sham rats, whilst the resistive exercise program was effective in augmenting the bone mass in sham and Ovx rats.

Authors+Show Affiliations

Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17368767

Citation

Shiguemoto, Gilberto Eiji, et al. "Isoflavone-supplemented Soy Yoghurt Associated With Resistive Physical Exercise Increase Bone Mineral Density of Ovariectomized Rats." Maturitas, vol. 57, no. 3, 2007, pp. 261-70.
Shiguemoto GE, Rossi EA, Baldissera V, et al. Isoflavone-supplemented soy yoghurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats. Maturitas. 2007;57(3):261-70.
Shiguemoto, G. E., Rossi, E. A., Baldissera, V., Gouveia, C. H., de Valdez Vargas, G. M., & de Andrade Perez, S. E. (2007). Isoflavone-supplemented soy yoghurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats. Maturitas, 57(3), pp. 261-70.
Shiguemoto GE, et al. Isoflavone-supplemented Soy Yoghurt Associated With Resistive Physical Exercise Increase Bone Mineral Density of Ovariectomized Rats. Maturitas. 2007 Jul 20;57(3):261-70. PubMed PMID: 17368767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavone-supplemented soy yoghurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats. AU - Shiguemoto,Gilberto Eiji, AU - Rossi,Elizeu Antonio, AU - Baldissera,Vilmar, AU - Gouveia,Cecília Helena, AU - de Valdez Vargas,Graciela Maria Font, AU - de Andrade Perez,Sérgio Eduardo, Y1 - 2007/03/26/ PY - 2006/11/03/received PY - 2007/01/10/revised PY - 2007/01/16/accepted PY - 2007/3/21/pubmed PY - 2007/8/24/medline PY - 2007/3/21/entrez SP - 261 EP - 70 JF - Maturitas JO - Maturitas VL - 57 IS - 3 N2 - OBJECTIVE: To determine the effects produced by the ingestion of a fermented soy product (soy yoghurt), supplemented with isoflavones and associated with a resistive exercise program, on the bone metabolism of mature ovariectomized (Ovx) and sham-ovariectomized (sham-Ovx) rats. METHODS: A total of 56 rats were used. They were divided into 2 sedentary control groups, the Ovx control group (C-Ovx) and the sham-Ovx control group (C-Sovx), each with 7 sedentary animals, and 2 treated groups, Ovx and sham-Ovx, with 21 animals each. These two treated groups were subdivided into three subgroups of seven animals each, which received the following treatments: consuming the soy yoghurt+sedentary, only subjected to resistive exercise, and consuming the soy yoghurt+resistive exercise. Both the program of resistive exercise and the consumption of soy yoghurt (at 3 mL/(kg body weight day)) continued for 12 weeks. The soy yoghurt was supplemented with isoflavones at 50mg/100g of product. The animals were sacrificed and their right-side femurs and tibias removed and assessed for bone mineral density (BMD). The alkaline phosphatase activity (AP) was determined in the blood serum. RESULTS: There was a significant increase in both femur and tibia BMD values and in serum alkaline phosphatase activity in all the treated subgroups, compared with the control groups (p<0.05). CONCLUSION: The ingestion of the soy yoghurt supplemented with isoflavones was capable of preventing a loss of bone mass in Ovx rats and of increasing bone mass in sham rats, whilst the resistive exercise program was effective in augmenting the bone mass in sham and Ovx rats. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/17368767/Isoflavone_supplemented_soy_yoghurt_associated_with_resistive_physical_exercise_increase_bone_mineral_density_of_ovariectomized_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(07)00035-7 DB - PRIME DP - Unbound Medicine ER -