Tags

Type your tag names separated by a space and hit enter

[Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer].
J Chir (Paris). 2007 Jan-Feb; 144(1):13-8.JC

Abstract

Tumors arising sporadically represent 70-80% of colorectal cancer (CRC). The two best defined forms of inherited CRC-familial multiple polyposis (FMP) and Hereditary Non-Polyposis Colon Cancer (HNPCC) account respectively for<1% and 2-3% of CRC. These rare genetic syndromes (FMP, HNPCC, Peutz-Jeghers Syndrome) are caused by major predisposing gene mutations (APC gene, MMR gene, BMPR1A. SMAD4,...) and local environmental factors play only a minor role. In the sporadic forms of CRC, 25% have significant genetic predisposition probably related to alleles with weak penetration (APC*I1307K, TGFbR1*6Ala...) and are more strongly affected by environmental factors.

Authors+Show Affiliations

Service de Chirurgie Digestive, Hôpital Henri Mondor - Créteil. mehdi.karoui@hmn.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

17369756

Citation

Karoui, M, et al. "[Colorectal Carcinogenesis. 1. Hereditary Predisposition and Colorectal Cancer]." Journal De Chirurgie, vol. 144, no. 1, 2007, pp. 13-8.
Karoui M, Tresallet C, Brouquet A, et al. [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer]. J Chir (Paris). 2007;144(1):13-8.
Karoui, M., Tresallet, C., Brouquet, A., Radvanyi, H., & Penna, C. (2007). [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer]. Journal De Chirurgie, 144(1), 13-8.
Karoui M, et al. [Colorectal Carcinogenesis. 1. Hereditary Predisposition and Colorectal Cancer]. J Chir (Paris). 2007 Jan-Feb;144(1):13-8. PubMed PMID: 17369756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer]. AU - Karoui,M, AU - Tresallet,C, AU - Brouquet,A, AU - Radvanyi,H, AU - Penna,C, PY - 2007/3/21/pubmed PY - 2007/4/26/medline PY - 2007/3/21/entrez SP - 13 EP - 8 JF - Journal de chirurgie JO - J Chir (Paris) VL - 144 IS - 1 N2 - Tumors arising sporadically represent 70-80% of colorectal cancer (CRC). The two best defined forms of inherited CRC-familial multiple polyposis (FMP) and Hereditary Non-Polyposis Colon Cancer (HNPCC) account respectively for<1% and 2-3% of CRC. These rare genetic syndromes (FMP, HNPCC, Peutz-Jeghers Syndrome) are caused by major predisposing gene mutations (APC gene, MMR gene, BMPR1A. SMAD4,...) and local environmental factors play only a minor role. In the sporadic forms of CRC, 25% have significant genetic predisposition probably related to alleles with weak penetration (APC*I1307K, TGFbR1*6Ala...) and are more strongly affected by environmental factors. SN - 0021-7697 UR - https://www.unboundmedicine.com/medline/citation/17369756/[Colorectal_carcinogenesis__1__Hereditary_predisposition_and_colorectal_cancer]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-JCHIR-01-02-2007-144-1-0021-7697-101019-200700215 DB - PRIME DP - Unbound Medicine ER -