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Similar development of cued and learned home bases in control and hippocampal-damaged rats in an open field exploratory task.
Hippocampus. 2007; 17(5):370-80.H

Abstract

Spatial behavior was examined in control rats and rats with neurotoxic-induced damage of the hippocampus in an open field "exploratory" task. In Experiment 1, rats were placed on a large circular table for 30 min for four consecutive days with a short wall adjacent to the table and a large black box near the edge of the table diametrically opposite to the wall. On the fifth day, rats were given a probe test during which both cues were removed. Over the training exposures both control and hippocampal-damaged rats formed "home bases," operationally defined as places where the rats preferentially stopped and spent time, near the cues. When the cues were removed on the probe day, both groups visited, stopped near, and spent time at places adjacent to the cues' previous location. In Experiment 2, rats were given a similar training protocol, but only a single cue was used, which was a small box placed directly on the table that did not block visibility of the entire room. On the fifth day, the box was moved to the other end of the table. Despite the presence of a cued home base, control and hippocampal-damaged rats remembered the original location of the home base. The results are discussed in relation to the comparative task demands of formal and informal test procedures and with respect to their relevance to understanding the neural basis of spatial behavior.

Authors+Show Affiliations

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, Lethbridge, Alberta, Canada T1K 4N6. hugo.lehmann@uleth.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17372977

Citation

Lehmann, Hugo, et al. "Similar Development of Cued and Learned Home Bases in Control and Hippocampal-damaged Rats in an Open Field Exploratory Task." Hippocampus, vol. 17, no. 5, 2007, pp. 370-80.
Lehmann H, Clark BJ, Whishaw IQ. Similar development of cued and learned home bases in control and hippocampal-damaged rats in an open field exploratory task. Hippocampus. 2007;17(5):370-80.
Lehmann, H., Clark, B. J., & Whishaw, I. Q. (2007). Similar development of cued and learned home bases in control and hippocampal-damaged rats in an open field exploratory task. Hippocampus, 17(5), 370-80.
Lehmann H, Clark BJ, Whishaw IQ. Similar Development of Cued and Learned Home Bases in Control and Hippocampal-damaged Rats in an Open Field Exploratory Task. Hippocampus. 2007;17(5):370-80. PubMed PMID: 17372977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similar development of cued and learned home bases in control and hippocampal-damaged rats in an open field exploratory task. AU - Lehmann,Hugo, AU - Clark,Benjamin J, AU - Whishaw,Ian Q, PY - 2007/3/21/pubmed PY - 2007/6/23/medline PY - 2007/3/21/entrez SP - 370 EP - 80 JF - Hippocampus JO - Hippocampus VL - 17 IS - 5 N2 - Spatial behavior was examined in control rats and rats with neurotoxic-induced damage of the hippocampus in an open field "exploratory" task. In Experiment 1, rats were placed on a large circular table for 30 min for four consecutive days with a short wall adjacent to the table and a large black box near the edge of the table diametrically opposite to the wall. On the fifth day, rats were given a probe test during which both cues were removed. Over the training exposures both control and hippocampal-damaged rats formed "home bases," operationally defined as places where the rats preferentially stopped and spent time, near the cues. When the cues were removed on the probe day, both groups visited, stopped near, and spent time at places adjacent to the cues' previous location. In Experiment 2, rats were given a similar training protocol, but only a single cue was used, which was a small box placed directly on the table that did not block visibility of the entire room. On the fifth day, the box was moved to the other end of the table. Despite the presence of a cued home base, control and hippocampal-damaged rats remembered the original location of the home base. The results are discussed in relation to the comparative task demands of formal and informal test procedures and with respect to their relevance to understanding the neural basis of spatial behavior. SN - 1050-9631 UR - https://www.unboundmedicine.com/medline/citation/17372977/Similar_development_of_cued_and_learned_home_bases_in_control_and_hippocampal_damaged_rats_in_an_open_field_exploratory_task_ L2 - https://doi.org/10.1002/hipo.20274 DB - PRIME DP - Unbound Medicine ER -