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Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease.
Aliment Pharmacol Ther. 2007 Apr 01; 25(7):797-804.AP

Abstract

BACKGROUND

A high prevalence of osteoporosis is observed in Crohn's disease. Recent data have shown that homocysteinaemia is an important risk factor in low-bone mineralization and fracture.

AIM

To look for an association between homocysteinaemia and low-bone mineralization in Crohn's disease patients.

PATIENTS AND METHODS

Ninety-two consecutive patients (sex ratio M/F 0.87; mean age: 36.6 +/- 13.2 years) were recruited between 2003 and 2005. Bone densitometry was performed on inclusion. The following parameters were analysed: age, sex, Crohn's Disease Activity Index, duration and extent of Crohn's disease, smoking status, corticosteroid treatment, immunosuppressive drugs, plasma homocysteine, folate and vitamin B12 concentration.

RESULTS

The prevalence of a high homocysteine level (>15 micromol/L) was 60%. Osteoporosis and low-bone mineralization observed in 26 (28%), and 60 (65%) patients, respectively. On a multivariate analysis, associated factors for osteoporosis and low-bone mineralization were respectively: hyperhomocysteinaemia (OR: 61.4; CI: 95: 23-250; P < 0.001), and ileal Crohn's disease [OR: 13.8; CI: 95: 2.5-150; P = 0.036] for osteoporosis and hyperhomocysteinaemia [OR: 63.7; CI: 95: 8.5-250; P < 0.001] and disease duration of at least 5 years [OR: 11.4; CI: 95: 1.31-99; P = 0.039] for low-bone mineralization. Results were similar whichever site osteoporosis was detected.

CONCLUSION

Hyperhomocysteinaemia was observed in 60% of our Crohn's disease patients and was strongly associated with low-bone mineralization and osteoporosis (OR: 61.4).

Authors+Show Affiliations

Department of Gastroenterology and Liver Diseases, CHU de Grenoble, Grenoble, France. xroblin@chu-grenoble.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17373918

Citation

Roblin, X, et al. "Hyperhomocysteinaemia Is Associated With Osteoporosis in Patients With Crohn's Disease." Alimentary Pharmacology & Therapeutics, vol. 25, no. 7, 2007, pp. 797-804.
Roblin X, Phelip JM, Genevois M, et al. Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease. Aliment Pharmacol Ther. 2007;25(7):797-804.
Roblin, X., Phelip, J. M., Genevois, M., Ducros, V., & Bonaz, B. (2007). Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease. Alimentary Pharmacology & Therapeutics, 25(7), 797-804.
Roblin X, et al. Hyperhomocysteinaemia Is Associated With Osteoporosis in Patients With Crohn's Disease. Aliment Pharmacol Ther. 2007 Apr 1;25(7):797-804. PubMed PMID: 17373918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease. AU - Roblin,X, AU - Phelip,J M, AU - Genevois,M, AU - Ducros,V, AU - Bonaz,B, PY - 2007/3/22/pubmed PY - 2007/8/19/medline PY - 2007/3/22/entrez SP - 797 EP - 804 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 25 IS - 7 N2 - BACKGROUND: A high prevalence of osteoporosis is observed in Crohn's disease. Recent data have shown that homocysteinaemia is an important risk factor in low-bone mineralization and fracture. AIM: To look for an association between homocysteinaemia and low-bone mineralization in Crohn's disease patients. PATIENTS AND METHODS: Ninety-two consecutive patients (sex ratio M/F 0.87; mean age: 36.6 +/- 13.2 years) were recruited between 2003 and 2005. Bone densitometry was performed on inclusion. The following parameters were analysed: age, sex, Crohn's Disease Activity Index, duration and extent of Crohn's disease, smoking status, corticosteroid treatment, immunosuppressive drugs, plasma homocysteine, folate and vitamin B12 concentration. RESULTS: The prevalence of a high homocysteine level (>15 micromol/L) was 60%. Osteoporosis and low-bone mineralization observed in 26 (28%), and 60 (65%) patients, respectively. On a multivariate analysis, associated factors for osteoporosis and low-bone mineralization were respectively: hyperhomocysteinaemia (OR: 61.4; CI: 95: 23-250; P < 0.001), and ileal Crohn's disease [OR: 13.8; CI: 95: 2.5-150; P = 0.036] for osteoporosis and hyperhomocysteinaemia [OR: 63.7; CI: 95: 8.5-250; P < 0.001] and disease duration of at least 5 years [OR: 11.4; CI: 95: 1.31-99; P = 0.039] for low-bone mineralization. Results were similar whichever site osteoporosis was detected. CONCLUSION: Hyperhomocysteinaemia was observed in 60% of our Crohn's disease patients and was strongly associated with low-bone mineralization and osteoporosis (OR: 61.4). SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17373918/Hyperhomocysteinaemia_is_associated_with_osteoporosis_in_patients_with_Crohn's_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2007.03260.x DB - PRIME DP - Unbound Medicine ER -