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Combination of 308-nm xenon chloride excimer laser and topical calcipotriol in vitiligo.
J Eur Acad Dermatol Venereol. 2007 Apr; 21(4):504-8.JE

Abstract

BACKGROUND

A large variety of therapeutic agents are being used for the treatment of vitiligo, but treatment remains a challenge. Recently, monochromatic phototherapies such as 311-nm narrowband ultraviolet B therapy and 308-nm xenon chloride excimer laser have been reported to be an effective and safe therapeutic option in children and adult patients with vitiligo. Single reports stipulate that the addition of topically applied calcipotriol to phototherapy increases its effectiveness.

OBJECTIVE

The purpose of the present pilot study was to determine if the addition of topical calcipotriol increases the efficacy of the 308-nm xenon chloride excimer in the treatment of vitiligo.

METHODS

Ten patients with vitiligo with essentially bilateral symmetrical lesions were enrolled in this prospective right/left comparative, single-blinded trial conducted over a 15-month period. All patients received 308-nm XeCl excimer laser therapy three times weekly. Calcipotriol ointment (Daivonex) was applied to lesions on one side of the body twice daily.

RESULTS

After 24 treatments (8 weeks), nine patients were evaluated. Eight patients showed evidence of repigmentation on both body sides, with no significant difference between the body side treated with calcipotriol and excimer laser and the side treated with excimer laser alone. The mean repigmentation rate was 22.4% (1-37%).

CONCLUSION

The addition of calcipotriol ointment to 308-nm xenon chloride excimer laser phototherapy does not significantly enhance its efficacy. Small additive effects must be investigated in a larger trial.

Authors+Show Affiliations

Department of Dermatology, University of Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17373978

Citation

Goldinger, S M., et al. "Combination of 308-nm Xenon Chloride Excimer Laser and Topical Calcipotriol in Vitiligo." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 21, no. 4, 2007, pp. 504-8.
Goldinger SM, Dummer R, Schmid P, et al. Combination of 308-nm xenon chloride excimer laser and topical calcipotriol in vitiligo. J Eur Acad Dermatol Venereol. 2007;21(4):504-8.
Goldinger, S. M., Dummer, R., Schmid, P., Burg, G., Seifert, B., & Läuchli, S. (2007). Combination of 308-nm xenon chloride excimer laser and topical calcipotriol in vitiligo. Journal of the European Academy of Dermatology and Venereology : JEADV, 21(4), 504-8.
Goldinger SM, et al. Combination of 308-nm Xenon Chloride Excimer Laser and Topical Calcipotriol in Vitiligo. J Eur Acad Dermatol Venereol. 2007;21(4):504-8. PubMed PMID: 17373978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of 308-nm xenon chloride excimer laser and topical calcipotriol in vitiligo. AU - Goldinger,S M, AU - Dummer,R, AU - Schmid,P, AU - Burg,G, AU - Seifert,B, AU - Läuchli,S, PY - 2007/3/22/pubmed PY - 2007/7/19/medline PY - 2007/3/22/entrez SP - 504 EP - 8 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 21 IS - 4 N2 - BACKGROUND: A large variety of therapeutic agents are being used for the treatment of vitiligo, but treatment remains a challenge. Recently, monochromatic phototherapies such as 311-nm narrowband ultraviolet B therapy and 308-nm xenon chloride excimer laser have been reported to be an effective and safe therapeutic option in children and adult patients with vitiligo. Single reports stipulate that the addition of topically applied calcipotriol to phototherapy increases its effectiveness. OBJECTIVE: The purpose of the present pilot study was to determine if the addition of topical calcipotriol increases the efficacy of the 308-nm xenon chloride excimer in the treatment of vitiligo. METHODS: Ten patients with vitiligo with essentially bilateral symmetrical lesions were enrolled in this prospective right/left comparative, single-blinded trial conducted over a 15-month period. All patients received 308-nm XeCl excimer laser therapy three times weekly. Calcipotriol ointment (Daivonex) was applied to lesions on one side of the body twice daily. RESULTS: After 24 treatments (8 weeks), nine patients were evaluated. Eight patients showed evidence of repigmentation on both body sides, with no significant difference between the body side treated with calcipotriol and excimer laser and the side treated with excimer laser alone. The mean repigmentation rate was 22.4% (1-37%). CONCLUSION: The addition of calcipotriol ointment to 308-nm xenon chloride excimer laser phototherapy does not significantly enhance its efficacy. Small additive effects must be investigated in a larger trial. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/17373978/Combination_of_308_nm_xenon_chloride_excimer_laser_and_topical_calcipotriol_in_vitiligo_ L2 - https://doi.org/10.1111/j.1468-3083.2006.02016.x DB - PRIME DP - Unbound Medicine ER -