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Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status.

Abstract

BACKGROUND

Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is associated with a reduced risk of breast cancer. However, the potential associations of other dietary phytoestrogens--i.e., the lignans or their bioactive metabolites, the enterolignans--with the risk of breast cancer are unclear.

METHODS

We prospectively examined associations between the risk of postmenopausal invasive breast cancer and dietary intakes of four plant lignans (pinoresinol, lariciresinol, secoisolariciresinol, and matairesinol) and estimated exposure to two enterolignans (enterodiol and enterolactone), as measured with a self-administered diet history questionnaire, among 58,049 postmenopausal French women who were not taking soy isoflavone supplements. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards regression models. Analyses were further stratified by the combined estrogen and progesterone receptor (ER/PR) status of the tumors. Statistical tests were two-sided.

RESULTS

During 383,425 person-years of follow-up (median follow-up, 7.7 years), 1469 cases of breast cancer were diagnosed. Compared with women in the lowest intake quartiles, those in the highest quartile of total lignan intake (>1395 microg/day) had a reduced risk of breast cancer (RR = 0.83, 95% CI = 0.71 to 0.95, P(trend) = .02, 376 versus 411 cases per 100,000 person-years), as did those in the highest quartile of lariciresinol intake (RR = 0.82, 95% CI = 0.71 to 0.95, P(trend) = .01). The inverse associations between phytoestrogen intakes and postmenopausal breast cancer risk were limited to ER- and PR-positive disease (e.g., RR for highest versus lowest quartiles of total plant lignan intake = 0.72, 95% CI = 0.58 to 0.88, P(trend) = .01, 174 versus 214 cases per 100,000 person-years, and RR for highest versus lowest quartiles of total enterolignan level = 0.77, 95% CI = 0.62 to 0.95, P(trend) = .01, 164 versus 204 cases per 100,000 person-years).

CONCLUSIONS

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer in a Western population that does not consume a diet rich in soy.

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  • Authors+Show Affiliations

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    Institut National de la Santé et de la Recherche Médicale, ERI 20, Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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    Source

    Journal of the National Cancer Institute 99:6 2007 Mar 21 pg 475-86

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Diet Surveys
    Feeding Behavior
    Female
    Follow-Up Studies
    France
    Humans
    Lignans
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Postmenopause
    Proportional Hazards Models
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Reproducibility of Results
    Research Design
    Risk Assessment
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17374837

    Citation

    Touillaud, Marina S., et al. "Dietary Lignan Intake and Postmenopausal Breast Cancer Risk By Estrogen and Progesterone Receptor Status." Journal of the National Cancer Institute, vol. 99, no. 6, 2007, pp. 475-86.
    Touillaud MS, Thiébaut AC, Fournier A, et al. Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. J Natl Cancer Inst. 2007;99(6):475-86.
    Touillaud, M. S., Thiébaut, A. C., Fournier, A., Niravong, M., Boutron-Ruault, M. C., & Clavel-Chapelon, F. (2007). Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. Journal of the National Cancer Institute, 99(6), pp. 475-86.
    Touillaud MS, et al. Dietary Lignan Intake and Postmenopausal Breast Cancer Risk By Estrogen and Progesterone Receptor Status. J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PubMed PMID: 17374837.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. AU - Touillaud,Marina S, AU - Thiébaut,Anne C M, AU - Fournier,Agnès, AU - Niravong,Maryvonne, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, PY - 2007/3/22/pubmed PY - 2007/4/10/medline PY - 2007/3/22/entrez SP - 475 EP - 86 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 99 IS - 6 N2 - BACKGROUND: Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is associated with a reduced risk of breast cancer. However, the potential associations of other dietary phytoestrogens--i.e., the lignans or their bioactive metabolites, the enterolignans--with the risk of breast cancer are unclear. METHODS: We prospectively examined associations between the risk of postmenopausal invasive breast cancer and dietary intakes of four plant lignans (pinoresinol, lariciresinol, secoisolariciresinol, and matairesinol) and estimated exposure to two enterolignans (enterodiol and enterolactone), as measured with a self-administered diet history questionnaire, among 58,049 postmenopausal French women who were not taking soy isoflavone supplements. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards regression models. Analyses were further stratified by the combined estrogen and progesterone receptor (ER/PR) status of the tumors. Statistical tests were two-sided. RESULTS: During 383,425 person-years of follow-up (median follow-up, 7.7 years), 1469 cases of breast cancer were diagnosed. Compared with women in the lowest intake quartiles, those in the highest quartile of total lignan intake (>1395 microg/day) had a reduced risk of breast cancer (RR = 0.83, 95% CI = 0.71 to 0.95, P(trend) = .02, 376 versus 411 cases per 100,000 person-years), as did those in the highest quartile of lariciresinol intake (RR = 0.82, 95% CI = 0.71 to 0.95, P(trend) = .01). The inverse associations between phytoestrogen intakes and postmenopausal breast cancer risk were limited to ER- and PR-positive disease (e.g., RR for highest versus lowest quartiles of total plant lignan intake = 0.72, 95% CI = 0.58 to 0.88, P(trend) = .01, 174 versus 214 cases per 100,000 person-years, and RR for highest versus lowest quartiles of total enterolignan level = 0.77, 95% CI = 0.62 to 0.95, P(trend) = .01, 164 versus 204 cases per 100,000 person-years). CONCLUSIONS: High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer in a Western population that does not consume a diet rich in soy. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/17374837/Dietary_lignan_intake_and_postmenopausal_breast_cancer_risk_by_estrogen_and_progesterone_receptor_status_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djk096 DB - PRIME DP - Unbound Medicine ER -