Tags

Type your tag names separated by a space and hit enter

Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment.
Dement Geriatr Cogn Disord 2007; 23(5):316-20DG

Abstract

Evidence supports an important role for beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long Abeta peptides (Abeta40 and Abeta42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4-6 years of follow-up time. CSF Abeta42 concentration at baseline and the Abeta42/Abeta40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia (p < 0.001). The baseline levels of Abeta40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The Abeta42/Abeta40 ratio was superior to Abeta42 concentration with regard to identifying incipient AD in MCI (p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the Abeta42/Abeta40 ratio as a predictive biomarker for AD.

Authors+Show Affiliations

Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17374949

Citation

Hansson, Oskar, et al. "Prediction of Alzheimer's Disease Using the CSF Abeta42/Abeta40 Ratio in Patients With Mild Cognitive Impairment." Dementia and Geriatric Cognitive Disorders, vol. 23, no. 5, 2007, pp. 316-20.
Hansson O, Zetterberg H, Buchhave P, et al. Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment. Dement Geriatr Cogn Disord. 2007;23(5):316-20.
Hansson, O., Zetterberg, H., Buchhave, P., Andreasson, U., Londos, E., Minthon, L., & Blennow, K. (2007). Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 23(5), pp. 316-20.
Hansson O, et al. Prediction of Alzheimer's Disease Using the CSF Abeta42/Abeta40 Ratio in Patients With Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 2007;23(5):316-20. PubMed PMID: 17374949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment. AU - Hansson,Oskar, AU - Zetterberg,Henrik, AU - Buchhave,Peder, AU - Andreasson,Ulf, AU - Londos,Elisabet, AU - Minthon,Lennart, AU - Blennow,Kaj, Y1 - 2007/03/19/ PY - 2007/01/18/accepted PY - 2007/3/22/pubmed PY - 2007/6/21/medline PY - 2007/3/22/entrez SP - 316 EP - 20 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 23 IS - 5 N2 - Evidence supports an important role for beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long Abeta peptides (Abeta40 and Abeta42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4-6 years of follow-up time. CSF Abeta42 concentration at baseline and the Abeta42/Abeta40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia (p < 0.001). The baseline levels of Abeta40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The Abeta42/Abeta40 ratio was superior to Abeta42 concentration with regard to identifying incipient AD in MCI (p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the Abeta42/Abeta40 ratio as a predictive biomarker for AD. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17374949/Prediction_of_Alzheimer's_disease_using_the_CSF_Abeta42/Abeta40_ratio_in_patients_with_mild_cognitive_impairment_ L2 - https://www.karger.com?DOI=10.1159/000100926 DB - PRIME DP - Unbound Medicine ER -