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Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia.
Dement Geriatr Cogn Disord 2007; 23(5):327-33DG

Abstract

BACKGROUND

Polymorphism in the apolipoprotein E (APOE) gene is the major genetic risk factor associated with late-onset Alzheimer's Disease (AD). However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects.

OBJECTIVES

To evaluate the prevalence of APOE alleles in elderly patients with VaD compared to AD patients and to control subjects with no cognitive impairment (NoCI).

PATIENTS AND METHODS

We evaluated 396 consecutive patients aged > or =65 years with definite or suspected cognitive impairment with a clinical (Mini-Mental State Examination, Clinical Dementia Rating, Geriatric Depression Scale), functional (Activities of Daily Living, Instrumental Activities of Daily Living), comorbidity (Cumulative Illness Rating Scale) and instrumental (CT scan, NMR) assessment. Diagnosis of dementia was made according to NINCDS-ADRDA and NINDS-AIREN Work Group and the DSM-IV. APOE genotypes were analyzed by a recently described method resulting in positive/negative chain reaction products for each APOE genotype. Statistical analysis was carried out using the Pearson chi(2), the Kruskal-Wallis test and the ANOVA post hoc comparisons.

RESULTS

A total of 287 elderly patients (males = 138, females = 149, mean age = 77.8 +/- 6.9 years, range = 65-98) with diagnoses of VaD (n = 97), AD (n = 82) or NoCI (n = 108) were included in the study. A significantly higher APOE epsilon4 allele frequency was observed in AD patients compared to VaD and/or NoCI subjects, while no differences were found between VaD patients and subjects with NoCI (AD = 24.3%, VaD = 10.3, NoCI = 8.7, p < 0.05). Furthermore, a significantly lower APOE epsilon3 allele frequency was observed in AD patients compared to VaD and/or NoCI subjects but not between VaD and NoCI patients (AD = 71.3%, VaD = 80.9, NoCI = 83.4, p < 0.05). No significant differences were observed in the APOE epsilon2 allele (VaD = 8.8%, AD = 4.4, NoCI = 7.9, p = n.s.) among the 3 groups.

CONCLUSIONS

In this population, the frequency of the APOE epsilon4 allele is lower in VaD than in AD.

Authors+Show Affiliations

Geriatric Unit, Medical Sciences Department, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17374951

Citation

Orsitto, Giuseppe, et al. "Apolipoprotein E Genotypes in Hospitalized Elderly Patients With Vascular Dementia." Dementia and Geriatric Cognitive Disorders, vol. 23, no. 5, 2007, pp. 327-33.
Orsitto G, Seripa D, Panza F, et al. Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia. Dement Geriatr Cogn Disord. 2007;23(5):327-33.
Orsitto, G., Seripa, D., Panza, F., Franceschi, M., Cascavilla, L., Placentino, G., ... Pilotto, A. (2007). Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia. Dementia and Geriatric Cognitive Disorders, 23(5), pp. 327-33.
Orsitto G, et al. Apolipoprotein E Genotypes in Hospitalized Elderly Patients With Vascular Dementia. Dement Geriatr Cogn Disord. 2007;23(5):327-33. PubMed PMID: 17374951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia. AU - Orsitto,Giuseppe, AU - Seripa,Davide, AU - Panza,Francesco, AU - Franceschi,Marilisa, AU - Cascavilla,Leandro, AU - Placentino,Giuliana, AU - Matera,Maria Giovanna, AU - Paris,Francesco, AU - Capurso,Cristiano, AU - Solfrizzi,Vincenzo, AU - Dallapiccola,Bruno, AU - Pilotto,Alberto, Y1 - 2007/03/19/ PY - 2007/01/17/accepted PY - 2007/3/22/pubmed PY - 2007/6/21/medline PY - 2007/3/22/entrez SP - 327 EP - 33 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 23 IS - 5 N2 - BACKGROUND: Polymorphism in the apolipoprotein E (APOE) gene is the major genetic risk factor associated with late-onset Alzheimer's Disease (AD). However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects. OBJECTIVES: To evaluate the prevalence of APOE alleles in elderly patients with VaD compared to AD patients and to control subjects with no cognitive impairment (NoCI). PATIENTS AND METHODS: We evaluated 396 consecutive patients aged > or =65 years with definite or suspected cognitive impairment with a clinical (Mini-Mental State Examination, Clinical Dementia Rating, Geriatric Depression Scale), functional (Activities of Daily Living, Instrumental Activities of Daily Living), comorbidity (Cumulative Illness Rating Scale) and instrumental (CT scan, NMR) assessment. Diagnosis of dementia was made according to NINCDS-ADRDA and NINDS-AIREN Work Group and the DSM-IV. APOE genotypes were analyzed by a recently described method resulting in positive/negative chain reaction products for each APOE genotype. Statistical analysis was carried out using the Pearson chi(2), the Kruskal-Wallis test and the ANOVA post hoc comparisons. RESULTS: A total of 287 elderly patients (males = 138, females = 149, mean age = 77.8 +/- 6.9 years, range = 65-98) with diagnoses of VaD (n = 97), AD (n = 82) or NoCI (n = 108) were included in the study. A significantly higher APOE epsilon4 allele frequency was observed in AD patients compared to VaD and/or NoCI subjects, while no differences were found between VaD patients and subjects with NoCI (AD = 24.3%, VaD = 10.3, NoCI = 8.7, p < 0.05). Furthermore, a significantly lower APOE epsilon3 allele frequency was observed in AD patients compared to VaD and/or NoCI subjects but not between VaD and NoCI patients (AD = 71.3%, VaD = 80.9, NoCI = 83.4, p < 0.05). No significant differences were observed in the APOE epsilon2 allele (VaD = 8.8%, AD = 4.4, NoCI = 7.9, p = n.s.) among the 3 groups. CONCLUSIONS: In this population, the frequency of the APOE epsilon4 allele is lower in VaD than in AD. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17374951/Apolipoprotein_E_genotypes_in_hospitalized_elderly_patients_with_vascular_dementia_ L2 - https://www.karger.com?DOI=10.1159/000100972 DB - PRIME DP - Unbound Medicine ER -