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Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research.
Electromyogr Clin Neurophysiol. 2007 Jan-Feb; 47(1):11-22.EC

Abstract

PURPOSE

The aim of this study was to provide a data base for the measurement of various parameters of the pupil light reflex in normal subjects using a fast video pupillometry device (262 frames/sec).

METHOD

One hundred healthy subjects took part in the study aged 44.31+/-18.11 years. Subjects were divided in two (2) groups according to age: 18-50 years of age (group 1) and 51-81 years of age (group 2). All subjects were examined between 09.00 and 15.00 and the re-test examination was repeated exactly 24 hours later. All variables showed satisfactory test-retest reliability (Pearson test-retest showed values over 0. 70 for all parameters besides Time for Maximum Constriction (T3. 0.62) and Recovery (R%: 0.57)).

RESULTS

The Latency of pupil reaction to light (Ti) was not affected by Age. Baseline Pupil Radius (RI) after 2 min of dark adaptation was statistically smaller in the elderly group p < 0.001; Maximum Constriction Velocity (VCmax), Maximum Constriction Acceleration (ACmax) and Amplitude (AMP) were significantly smaller in the elderly group (p < 0.001) when compared to group 1. When all parameters were studied their correlation showed a statistical significant difference for R1, R2, VCmax, ACmax and AMP when related to Age. However when Age was taken into account through the use of partial correlation, the relation between R1, R2 and AMP remained unaltered, but the relations between R1 and VCmax and ACmax were dramatically reduced from -0.39 to -0.21 and from -0.45 to -0.09 respectively indicating that the relation observed between Ri and VCmax and ACmax was due mainly to the Age of the subjects.

CONCLUSION

The results suggest that age influences Baseline Pupil Size, Maximum Constriction Velocity (VCmax) and Acceleration (ACmax), while the Latency of the light reflex remains unaltered.

Authors+Show Affiliations

Laboratory of Clinical Neurophysiology, Medical School, University Hospital AHEPA, Aristotle University of Thessaloniki, Thessaloniki, Greece. ffot@auth.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17375877

Citation

Fotiou, D F., et al. "Effect of Age On Pupillary Light Reflex: Evaluation of Pupil Mobility for Clinical Practice and Research." Electromyography and Clinical Neurophysiology, vol. 47, no. 1, 2007, pp. 11-22.
Fotiou DF, Brozou CG, Tsiptsios DJ, et al. Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research. Electromyogr Clin Neurophysiol. 2007;47(1):11-22.
Fotiou, D. F., Brozou, C. G., Tsiptsios, D. J., Fotiou, A., Kabitsi, A., Nakou, M., Giantselidis, C., & Goula, A. (2007). Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research. Electromyography and Clinical Neurophysiology, 47(1), 11-22.
Fotiou DF, et al. Effect of Age On Pupillary Light Reflex: Evaluation of Pupil Mobility for Clinical Practice and Research. Electromyogr Clin Neurophysiol. 2007 Jan-Feb;47(1):11-22. PubMed PMID: 17375877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research. AU - Fotiou,D F, AU - Brozou,C G, AU - Tsiptsios,D J, AU - Fotiou,A, AU - Kabitsi,A, AU - Nakou,M, AU - Giantselidis,C, AU - Goula,A, PY - 2007/3/23/pubmed PY - 2007/4/25/medline PY - 2007/3/23/entrez SP - 11 EP - 22 JF - Electromyography and clinical neurophysiology JO - Electromyogr Clin Neurophysiol VL - 47 IS - 1 N2 - PURPOSE: The aim of this study was to provide a data base for the measurement of various parameters of the pupil light reflex in normal subjects using a fast video pupillometry device (262 frames/sec). METHOD: One hundred healthy subjects took part in the study aged 44.31+/-18.11 years. Subjects were divided in two (2) groups according to age: 18-50 years of age (group 1) and 51-81 years of age (group 2). All subjects were examined between 09.00 and 15.00 and the re-test examination was repeated exactly 24 hours later. All variables showed satisfactory test-retest reliability (Pearson test-retest showed values over 0. 70 for all parameters besides Time for Maximum Constriction (T3. 0.62) and Recovery (R%: 0.57)). RESULTS: The Latency of pupil reaction to light (Ti) was not affected by Age. Baseline Pupil Radius (RI) after 2 min of dark adaptation was statistically smaller in the elderly group p < 0.001; Maximum Constriction Velocity (VCmax), Maximum Constriction Acceleration (ACmax) and Amplitude (AMP) were significantly smaller in the elderly group (p < 0.001) when compared to group 1. When all parameters were studied their correlation showed a statistical significant difference for R1, R2, VCmax, ACmax and AMP when related to Age. However when Age was taken into account through the use of partial correlation, the relation between R1, R2 and AMP remained unaltered, but the relations between R1 and VCmax and ACmax were dramatically reduced from -0.39 to -0.21 and from -0.45 to -0.09 respectively indicating that the relation observed between Ri and VCmax and ACmax was due mainly to the Age of the subjects. CONCLUSION: The results suggest that age influences Baseline Pupil Size, Maximum Constriction Velocity (VCmax) and Acceleration (ACmax), while the Latency of the light reflex remains unaltered. SN - 0301-150X UR - https://www.unboundmedicine.com/medline/citation/17375877/Effect_of_age_on_pupillary_light_reflex:_evaluation_of_pupil_mobility_for_clinical_practice_and_research_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -