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Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years.
J Gastroenterol Hepatol. 2007 Apr; 22(4):510-4.JG

Abstract

BACKGROUND AND AIM

Although nonalcoholic fatty liver disease (NAFLD) is very common among morbidly obese patients, the effect of weight loss after bariatric surgery on inflammation and fibrosis related to NAFLD is still a matter of debate. The aim of this study was to evaluate the impact of Roux-en-Y gastric bypass (RYGB) surgery on NAFLD with a follow up of 2 years.

METHODS

Eighteen consecutive NAFLD patients with body mass index >40 kg/m(2) undergoing gastroplasty with RYGB were enrolled, and wedge liver biopsy was obtained at the operation. After 2 years, these patients underwent percutaneous liver biopsy.

RESULTS

At baseline, 67% of patients had nonalcoholic steatohepatitis (NASH) and 33% had steatosis, according to the NASH Clinical Research Network Scoring System (NAS) for biopsy. Cirrhosis was present in 5.5% of the patients with NASH. After a mean excess weight loss of 60%, steatosis disappeared in 84% and fibrosis disappeared in 75% of the patients. Hepatocellular ballooning disappeared in 50%. A slight lobular inflammatory infiltrate remained in 81%, apparently unrelated to fatty degeneration. As liver biochemical variables had been found within normal limits in 92.3% of patients at initial biopsy, no difference was found 2 years later. Lipid profile and blood sugar plasma concentration were closer to normal in all patients after 2 years (P < 0.05).

CONCLUSIONS

Aspects of NAFLD including steatohepatitis improved significantly with massive weight loss at 2 years after RYGB surgery. No patient in this series had progression of hepatic fibrosis.

Authors+Show Affiliations

Department of Gastroenterology, Division of Endocrinology, University of São Paulo School of Medicine, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17376042

Citation

Furuya, Carlos K., et al. "Effects of Bariatric Surgery On Nonalcoholic Fatty Liver Disease: Preliminary Findings After 2 Years." Journal of Gastroenterology and Hepatology, vol. 22, no. 4, 2007, pp. 510-4.
Furuya CK, de Oliveira CP, de Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol. 2007;22(4):510-4.
Furuya, C. K., de Oliveira, C. P., de Mello, E. S., Faintuch, J., Raskovski, A., Matsuda, M., Vezozzo, D. C., Halpern, A., Garrido, A. B., Alves, V. A., & Carrilho, F. J. (2007). Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. Journal of Gastroenterology and Hepatology, 22(4), 510-4.
Furuya CK, et al. Effects of Bariatric Surgery On Nonalcoholic Fatty Liver Disease: Preliminary Findings After 2 Years. J Gastroenterol Hepatol. 2007;22(4):510-4. PubMed PMID: 17376042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. AU - Furuya,Carlos K,Jr AU - de Oliveira,Claudia P M S, AU - de Mello,Evandro S, AU - Faintuch,Joel, AU - Raskovski,Alessandra, AU - Matsuda,Mitsunori, AU - Vezozzo,Denise C P, AU - Halpern,Alfredo, AU - Garrido,Arthur B,Jr AU - Alves,Venâncio A F, AU - Carrilho,Flair J, PY - 2007/3/23/pubmed PY - 2007/6/15/medline PY - 2007/3/23/entrez SP - 510 EP - 4 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 22 IS - 4 N2 - BACKGROUND AND AIM: Although nonalcoholic fatty liver disease (NAFLD) is very common among morbidly obese patients, the effect of weight loss after bariatric surgery on inflammation and fibrosis related to NAFLD is still a matter of debate. The aim of this study was to evaluate the impact of Roux-en-Y gastric bypass (RYGB) surgery on NAFLD with a follow up of 2 years. METHODS: Eighteen consecutive NAFLD patients with body mass index >40 kg/m(2) undergoing gastroplasty with RYGB were enrolled, and wedge liver biopsy was obtained at the operation. After 2 years, these patients underwent percutaneous liver biopsy. RESULTS: At baseline, 67% of patients had nonalcoholic steatohepatitis (NASH) and 33% had steatosis, according to the NASH Clinical Research Network Scoring System (NAS) for biopsy. Cirrhosis was present in 5.5% of the patients with NASH. After a mean excess weight loss of 60%, steatosis disappeared in 84% and fibrosis disappeared in 75% of the patients. Hepatocellular ballooning disappeared in 50%. A slight lobular inflammatory infiltrate remained in 81%, apparently unrelated to fatty degeneration. As liver biochemical variables had been found within normal limits in 92.3% of patients at initial biopsy, no difference was found 2 years later. Lipid profile and blood sugar plasma concentration were closer to normal in all patients after 2 years (P < 0.05). CONCLUSIONS: Aspects of NAFLD including steatohepatitis improved significantly with massive weight loss at 2 years after RYGB surgery. No patient in this series had progression of hepatic fibrosis. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17376042/Effects_of_bariatric_surgery_on_nonalcoholic_fatty_liver_disease:_preliminary_findings_after_2_years_ L2 - https://doi.org/10.1111/j.1440-1746.2007.04833.x DB - PRIME DP - Unbound Medicine ER -