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Efficacy of local heat therapy by radiofrequency in the treatment of cutaneous leishmaniasis, compared with intralesional injection of meglumine antimoniate.
Clin Exp Dermatol. 2007 Jul; 32(4):371-4.CE

Abstract

BACKGROUND

Cutaneous leishmaniasis (CL) is a serious public health problem in many tropical and subtropical regions of the world. Treatment of CL can prevent disfiguring scars.

AIM

The efficacy of local heat therapy by radiofrequency (RF) was compared with intralesional injection of meglumine antimoniate in the treatment of CL.

METHODS

This was a randomized clinical trial. Patients with antroponotic cutaneous leishmaniasis (ACL) in the Isfahan province of Iran were enrolled in the study if the examination of a smear from a suspected CL lesion was confirmed positive for Leishmania. Patients were randomly allocated to one of two treatment groups. Group A was treated by heat therapy by RF at 50 degrees C for 30 s once weekly for 4 weeks, and group B was treated with intralesional injection of meglumine antimoniate once weekly for 4 weeks. Follow-up lasted 6 months. Response to treatment was classified as complete (lesions flattened, no induration, and epidermal creases had appeared), partial (reduction in lesion size, but without the appearance of epidermal creases) and poor (no reduction in lesion size).

RESULTS

Of 117 participants, 57 patients with 83 lesions in group A and 60 patients with 94 lesions in group B completed the study and were followed up for 6 months. Complete, partial and poor response to treatment were 80.7%, 12% and 7.3% in group A, and 55.3%, 21.27% and 23.40% in group B, respectively (P = 0.001). In both groups, there was no relapse in patients with complete response after 6 months of follow-up.

CONCLUSIONS

Heat therapy with thermogenerator RF can be used as an efficacious treatment in the lesions of CL. It is more effective than the conventional treatment with intralesional meglumine antimoniate injection.

Authors+Show Affiliations

Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran. sadeghian@sdlrc.mui.ac.irNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17376205

Citation

Sadeghian, G, et al. "Efficacy of Local Heat Therapy By Radiofrequency in the Treatment of Cutaneous Leishmaniasis, Compared With Intralesional Injection of Meglumine Antimoniate." Clinical and Experimental Dermatology, vol. 32, no. 4, 2007, pp. 371-4.
Sadeghian G, Nilfroushzadeh MA, Iraji F. Efficacy of local heat therapy by radiofrequency in the treatment of cutaneous leishmaniasis, compared with intralesional injection of meglumine antimoniate. Clin Exp Dermatol. 2007;32(4):371-4.
Sadeghian, G., Nilfroushzadeh, M. A., & Iraji, F. (2007). Efficacy of local heat therapy by radiofrequency in the treatment of cutaneous leishmaniasis, compared with intralesional injection of meglumine antimoniate. Clinical and Experimental Dermatology, 32(4), 371-4.
Sadeghian G, Nilfroushzadeh MA, Iraji F. Efficacy of Local Heat Therapy By Radiofrequency in the Treatment of Cutaneous Leishmaniasis, Compared With Intralesional Injection of Meglumine Antimoniate. Clin Exp Dermatol. 2007;32(4):371-4. PubMed PMID: 17376205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of local heat therapy by radiofrequency in the treatment of cutaneous leishmaniasis, compared with intralesional injection of meglumine antimoniate. AU - Sadeghian,G, AU - Nilfroushzadeh,M A, AU - Iraji,F, Y1 - 2007/03/21/ PY - 2007/3/23/pubmed PY - 2007/10/2/medline PY - 2007/3/23/entrez SP - 371 EP - 4 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 32 IS - 4 N2 - BACKGROUND: Cutaneous leishmaniasis (CL) is a serious public health problem in many tropical and subtropical regions of the world. Treatment of CL can prevent disfiguring scars. AIM: The efficacy of local heat therapy by radiofrequency (RF) was compared with intralesional injection of meglumine antimoniate in the treatment of CL. METHODS: This was a randomized clinical trial. Patients with antroponotic cutaneous leishmaniasis (ACL) in the Isfahan province of Iran were enrolled in the study if the examination of a smear from a suspected CL lesion was confirmed positive for Leishmania. Patients were randomly allocated to one of two treatment groups. Group A was treated by heat therapy by RF at 50 degrees C for 30 s once weekly for 4 weeks, and group B was treated with intralesional injection of meglumine antimoniate once weekly for 4 weeks. Follow-up lasted 6 months. Response to treatment was classified as complete (lesions flattened, no induration, and epidermal creases had appeared), partial (reduction in lesion size, but without the appearance of epidermal creases) and poor (no reduction in lesion size). RESULTS: Of 117 participants, 57 patients with 83 lesions in group A and 60 patients with 94 lesions in group B completed the study and were followed up for 6 months. Complete, partial and poor response to treatment were 80.7%, 12% and 7.3% in group A, and 55.3%, 21.27% and 23.40% in group B, respectively (P = 0.001). In both groups, there was no relapse in patients with complete response after 6 months of follow-up. CONCLUSIONS: Heat therapy with thermogenerator RF can be used as an efficacious treatment in the lesions of CL. It is more effective than the conventional treatment with intralesional meglumine antimoniate injection. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17376205/Efficacy_of_local_heat_therapy_by_radiofrequency_in_the_treatment_of_cutaneous_leishmaniasis_compared_with_intralesional_injection_of_meglumine_antimoniate_ L2 - https://doi.org/10.1111/j.1365-2230.2007.02405.x DB - PRIME DP - Unbound Medicine ER -