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Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans.
Toxicology 2007; 234(1-2):113-23T

Abstract

Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence is regarded as a main factor in the pathophysiology of various diseases and ageing. Many flavonoids that are present in herbal edibles have antioxidative properties and possess a remarkable spectrum of biochemical and pharmacological actions. They are assumed to exert beneficial effects but the precise biological mechanism of their action is unknown. In this project, we studied effects of the flavonoids quercetin and rutin in the multicellular model organism Caenorhabditis elegans that exhibits a strong conservation in molecular and cellular pathways to mammals. Both flavonoids reduced the ROS accumulation at thermal stress and the extent of induced oxidative stress with quercetin having a stronger impact. The higher antioxidative activity of quercetin may explain the protection against lethal thermal stress and the reduction in accumulation of the ageing marker lipofuscin exerted by quercetin but not by rutin. The subcellular distribution of the FoxO transcription factor DAF-16 was only affected by quercetin indicating a modulatory effect of quercetin on signalling cascade(s). These results suggest that quercetin may act as an antioxidant as well as a modulator of cellular signalling processes to exert its protective properties.

Authors+Show Affiliations

Institute of Toxicology, Heinrich-Heine University, Düsseldorf, Germany. kampkoet@uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17376580

Citation

Kampkötter, Andreas, et al. "Investigations of Protective Effects of the Flavonoids Quercetin and Rutin On Stress Resistance in the Model Organism Caenorhabditis Elegans." Toxicology, vol. 234, no. 1-2, 2007, pp. 113-23.
Kampkötter A, Nkwonkam CG, Zurawski RF, et al. Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology. 2007;234(1-2):113-23.
Kampkötter, A., Nkwonkam, C. G., Zurawski, R. F., Timpel, C., Chovolou, Y., Wätjen, W., & Kahl, R. (2007). Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology, 234(1-2), pp. 113-23.
Kampkötter A, et al. Investigations of Protective Effects of the Flavonoids Quercetin and Rutin On Stress Resistance in the Model Organism Caenorhabditis Elegans. Toxicology. 2007 May 5;234(1-2):113-23. PubMed PMID: 17376580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. AU - Kampkötter,Andreas, AU - Nkwonkam,Christiane Gombitang, AU - Zurawski,Ruben Felix, AU - Timpel,Claudia, AU - Chovolou,Yvonni, AU - Wätjen,Wim, AU - Kahl,Regine, Y1 - 2007/02/21/ PY - 2007/01/12/received PY - 2007/02/13/revised PY - 2007/02/14/accepted PY - 2007/3/23/pubmed PY - 2007/8/19/medline PY - 2007/3/23/entrez SP - 113 EP - 23 JF - Toxicology JO - Toxicology VL - 234 IS - 1-2 N2 - Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence is regarded as a main factor in the pathophysiology of various diseases and ageing. Many flavonoids that are present in herbal edibles have antioxidative properties and possess a remarkable spectrum of biochemical and pharmacological actions. They are assumed to exert beneficial effects but the precise biological mechanism of their action is unknown. In this project, we studied effects of the flavonoids quercetin and rutin in the multicellular model organism Caenorhabditis elegans that exhibits a strong conservation in molecular and cellular pathways to mammals. Both flavonoids reduced the ROS accumulation at thermal stress and the extent of induced oxidative stress with quercetin having a stronger impact. The higher antioxidative activity of quercetin may explain the protection against lethal thermal stress and the reduction in accumulation of the ageing marker lipofuscin exerted by quercetin but not by rutin. The subcellular distribution of the FoxO transcription factor DAF-16 was only affected by quercetin indicating a modulatory effect of quercetin on signalling cascade(s). These results suggest that quercetin may act as an antioxidant as well as a modulator of cellular signalling processes to exert its protective properties. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17376580/Investigations_of_protective_effects_of_the_flavonoids_quercetin_and_rutin_on_stress_resistance_in_the_model_organism_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(07)00100-X DB - PRIME DP - Unbound Medicine ER -