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Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies.
Prostaglandins Leukot Essent Fatty Acids. 2007 Apr; 76(4):189-203.PL

Abstract

The present paper evaluates the most recent randomized controlled trials assessing the efficacy of n-3 LCPUFA supplementation (with or without n-6 LCPUFA) during pregnancy, lactation, infancy and childhood on visual and cognitive development. Available evidence suggests a beneficial effect of maternal n-3 LCPUFA supplementation during pregnancy and lactation on cognitive development of infants and children, but not for visual development. Evidence for an effect of LCPUFA supplementation of preterm and term infants on cognitive development of infants remains inconclusive. However, supplementing term infants with daily doses of 100 mg docosahexaenoic acid plus 200 mg arachidonic acid improves visual development as measured by electrophysiological tests. Evidence for benefits of n-3 LCPUFA on cognitive development in healthy children older than 2 years of age is too limited to allow a clear conclusion. Taken together, the evidence for potential benefits of LCPUFA supplementation is promising but yet inconclusive.

Authors+Show Affiliations

Unilever Food and Health Research Institute, Unilever R and D, Vlaardingen, The Netherlands. ans.eilander@unilever.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17376662

Citation

Eilander, A, et al. "Effects of N-3 Long Chain Polyunsaturated Fatty Acid Supplementation On Visual and Cognitive Development Throughout Childhood: a Review of Human Studies." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 76, no. 4, 2007, pp. 189-203.
Eilander A, Hundscheid DC, Osendarp SJ, et al. Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids. 2007;76(4):189-203.
Eilander, A., Hundscheid, D. C., Osendarp, S. J., Transler, C., & Zock, P. L. (2007). Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 76(4), 189-203.
Eilander A, et al. Effects of N-3 Long Chain Polyunsaturated Fatty Acid Supplementation On Visual and Cognitive Development Throughout Childhood: a Review of Human Studies. Prostaglandins Leukot Essent Fatty Acids. 2007;76(4):189-203. PubMed PMID: 17376662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. AU - Eilander,A, AU - Hundscheid,D C, AU - Osendarp,S J, AU - Transler,C, AU - Zock,P L, Y1 - 2007/03/21/ PY - 2006/10/17/received PY - 2007/01/15/revised PY - 2007/01/19/accepted PY - 2007/3/23/pubmed PY - 2007/6/7/medline PY - 2007/3/23/entrez SP - 189 EP - 203 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 76 IS - 4 N2 - The present paper evaluates the most recent randomized controlled trials assessing the efficacy of n-3 LCPUFA supplementation (with or without n-6 LCPUFA) during pregnancy, lactation, infancy and childhood on visual and cognitive development. Available evidence suggests a beneficial effect of maternal n-3 LCPUFA supplementation during pregnancy and lactation on cognitive development of infants and children, but not for visual development. Evidence for an effect of LCPUFA supplementation of preterm and term infants on cognitive development of infants remains inconclusive. However, supplementing term infants with daily doses of 100 mg docosahexaenoic acid plus 200 mg arachidonic acid improves visual development as measured by electrophysiological tests. Evidence for benefits of n-3 LCPUFA on cognitive development in healthy children older than 2 years of age is too limited to allow a clear conclusion. Taken together, the evidence for potential benefits of LCPUFA supplementation is promising but yet inconclusive. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/17376662/Effects_of_n_3_long_chain_polyunsaturated_fatty_acid_supplementation_on_visual_and_cognitive_development_throughout_childhood:_a_review_of_human_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(07)00021-X DB - PRIME DP - Unbound Medicine ER -