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The relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine.
Anesth Analg. 2007 Apr; 104(4):904-7.A&A

Abstract

BACKGROUND

In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecal ropivacaine, levobupivacaine, and bupivacaine and to define their motor-blocking potency ratios.

METHODS

We enrolled 104 parturients undergoing elective cesarean delivery with combined spinal-epidural anesthesia and randomized them to one of three groups to receive intrathecal 0.5% (wt/vol) ropivacaine, levobupivacaine, or bupivacaine. The initial dose was 4 mg, and the testing interval was set at 1 mg. Efficacy was determined by the occurrence of any motor block in either lower limb (modified Bromage and hip motor function scale) within 5 min after the spinal injection.

RESULTS

As assessed using up-down analysis, intrathecal ED50 for motor block was 5.79 mg for ropivacaine (95% CI 4.62-6.96), 4.83 mg for levobupivacaine (95% CI 4.35-5.32) and 3.44 mg for bupivacaine (95% CI 2.55-4.34) (P < 0.0007). The relative motor blocking potency ratios were ropivacaine/bupivacaine 0.59 (95% CI, 0.42-0.82), ropivacaine/levobupivacaine 0.83 (95% CI 0.64-1.09), and levobupivacaine/bupivacaine 0.71 (95% CI 0.51-0.98).

CONCLUSIONS

There is a clinical profile of potency for motor block for the pipecolylxylidines when administered spinally: low, intermediate, and high for ropivacaine, levobupivacaine, and bupivacaine, respectively.

Authors+Show Affiliations

Department of Anesthesia, Città di Roma Hospital, Roma, Italy. michela_camorcia@yahoo.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17377104

Citation

Camorcia, Michela, et al. "The Relative Potencies for Motor Block After Intrathecal Ropivacaine, Levobupivacaine, and Bupivacaine." Anesthesia and Analgesia, vol. 104, no. 4, 2007, pp. 904-7.
Camorcia M, Capogna G, Berritta C, et al. The relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine. Anesth Analg. 2007;104(4):904-7.
Camorcia, M., Capogna, G., Berritta, C., & Columb, M. O. (2007). The relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine. Anesthesia and Analgesia, 104(4), 904-7.
Camorcia M, et al. The Relative Potencies for Motor Block After Intrathecal Ropivacaine, Levobupivacaine, and Bupivacaine. Anesth Analg. 2007;104(4):904-7. PubMed PMID: 17377104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine. AU - Camorcia,Michela, AU - Capogna,Giorgio, AU - Berritta,Cristiana, AU - Columb,Malachy O, PY - 2007/3/23/pubmed PY - 2007/4/14/medline PY - 2007/3/23/entrez SP - 904 EP - 7 JF - Anesthesia and analgesia JO - Anesth Analg VL - 104 IS - 4 N2 - BACKGROUND: In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecal ropivacaine, levobupivacaine, and bupivacaine and to define their motor-blocking potency ratios. METHODS: We enrolled 104 parturients undergoing elective cesarean delivery with combined spinal-epidural anesthesia and randomized them to one of three groups to receive intrathecal 0.5% (wt/vol) ropivacaine, levobupivacaine, or bupivacaine. The initial dose was 4 mg, and the testing interval was set at 1 mg. Efficacy was determined by the occurrence of any motor block in either lower limb (modified Bromage and hip motor function scale) within 5 min after the spinal injection. RESULTS: As assessed using up-down analysis, intrathecal ED50 for motor block was 5.79 mg for ropivacaine (95% CI 4.62-6.96), 4.83 mg for levobupivacaine (95% CI 4.35-5.32) and 3.44 mg for bupivacaine (95% CI 2.55-4.34) (P < 0.0007). The relative motor blocking potency ratios were ropivacaine/bupivacaine 0.59 (95% CI, 0.42-0.82), ropivacaine/levobupivacaine 0.83 (95% CI 0.64-1.09), and levobupivacaine/bupivacaine 0.71 (95% CI 0.51-0.98). CONCLUSIONS: There is a clinical profile of potency for motor block for the pipecolylxylidines when administered spinally: low, intermediate, and high for ropivacaine, levobupivacaine, and bupivacaine, respectively. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/17377104/The_relative_potencies_for_motor_block_after_intrathecal_ropivacaine_levobupivacaine_and_bupivacaine_ DB - PRIME DP - Unbound Medicine ER -