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Different degrees of fetal oxidative stress in elective and emergent cesarean section.

Abstract

BACKGROUND

Several studies have addressed the influence of labor and mode of delivery on oxidative stress. Still it is unclear whether oxidative stress is related to delivery itself or whether it reflects a pre-existing fetal oxidative status.

OBJECTIVE

To investigate whether the degree of fetal oxidative stress is different between distressed fetuses that were delivered by emergent cesarean section and non-distressed fetuses that were delivered by elective cesarean section.

METHODS

The protocol of this prospective study was approved by the Institutional Review Board Committee. Amniotic fluid and umbilical artery blood were prospectively collected from 21 parturients who were delivered by an emergent cesarean section for non-reassuring fetal heart rate pattern and from 21 parturients who were delivered by an elective cesarean section in a tertiary care center. Oxidative stress was evaluated in amniotic fluid, umbilical cord plasma and erythrocytes by determining malondialdehyde concentration and glutathione peroxidase (GPX) activity.

RESULTS

Malondialdehyde concentration was higher in amniotic fluid (mean +/- SEM) (2.2 +/- 0.7 nmol/l vs. 0.6 +/- 0.02 nmol/l, p < 0.05), in umbilical cord plasma (1.2 +/- 0.2 nmol/l vs. 0.7 +/- 0.3 nmol/l, p < 0.05) and in umbilical cord erythrocytes (159.6 +/- 48.6 nmol/g Hb vs. 85.8 +/- 5.2 nmol/g Hb, p < 0.05) in women delivering by emergent cesarean compared to those delivering by elective cesarean. GPX activity was enhanced in amniotic fluid (12.4 +/- 2.2 U/l vs. 5.1 +/- 0.6 U/l, p < 0.05) and GPX activity/hemoglobin ratio was higher in cord blood (22.0 +/- 0.8 U/g Hb vs. 18.7 +/- 0.9 U/g Hb, p < 0.05) in women delivering by emergent cesarean compared to those delivering by elective cesarean.

CONCLUSION

Distressed fetuses delivered by emergency cesarean exhibited increased malondialdehyde concentrations, an indicative parameter for oxidative damage, and enhanced GPX activity an antioxidant enzyme, in amniotic fluid and umbilical cord blood compared to non-distressed fetuses delivered by elective cesarean section. This is probably an indication of higher fetal oxidative stress.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. lurie@nashim.net

    , , , ,

    Source

    Neonatology 92:2 2007 pg 111-5

    MeSH

    Adult
    Amniotic Fluid
    Biomarkers
    Cesarean Section
    Emergency Treatment
    Erythrocytes
    Female
    Fetal Blood
    Fetal Distress
    Glutathione Peroxidase
    Heart Rate, Fetal
    Humans
    Infant, Newborn
    Male
    Malondialdehyde
    Oxidative Stress
    Pregnancy
    Pregnancy Complications
    Prospective Studies

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17377411

    Citation

    Lurie, Samuel, et al. "Different Degrees of Fetal Oxidative Stress in Elective and Emergent Cesarean Section." Neonatology, vol. 92, no. 2, 2007, pp. 111-5.
    Lurie S, Matas Z, Boaz M, et al. Different degrees of fetal oxidative stress in elective and emergent cesarean section. Neonatology. 2007;92(2):111-5.
    Lurie, S., Matas, Z., Boaz, M., Fux, A., Golan, A., & Sadan, O. (2007). Different degrees of fetal oxidative stress in elective and emergent cesarean section. Neonatology, 92(2), pp. 111-5.
    Lurie S, et al. Different Degrees of Fetal Oxidative Stress in Elective and Emergent Cesarean Section. Neonatology. 2007;92(2):111-5. PubMed PMID: 17377411.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Different degrees of fetal oxidative stress in elective and emergent cesarean section. AU - Lurie,Samuel, AU - Matas,Zippora, AU - Boaz,Mona, AU - Fux,Asora, AU - Golan,Abraham, AU - Sadan,Oscar, Y1 - 2007/03/21/ PY - 2006/08/25/received PY - 2006/11/15/accepted PY - 2007/3/23/pubmed PY - 2007/9/28/medline PY - 2007/3/23/entrez SP - 111 EP - 5 JF - Neonatology JO - Neonatology VL - 92 IS - 2 N2 - BACKGROUND: Several studies have addressed the influence of labor and mode of delivery on oxidative stress. Still it is unclear whether oxidative stress is related to delivery itself or whether it reflects a pre-existing fetal oxidative status. OBJECTIVE: To investigate whether the degree of fetal oxidative stress is different between distressed fetuses that were delivered by emergent cesarean section and non-distressed fetuses that were delivered by elective cesarean section. METHODS: The protocol of this prospective study was approved by the Institutional Review Board Committee. Amniotic fluid and umbilical artery blood were prospectively collected from 21 parturients who were delivered by an emergent cesarean section for non-reassuring fetal heart rate pattern and from 21 parturients who were delivered by an elective cesarean section in a tertiary care center. Oxidative stress was evaluated in amniotic fluid, umbilical cord plasma and erythrocytes by determining malondialdehyde concentration and glutathione peroxidase (GPX) activity. RESULTS: Malondialdehyde concentration was higher in amniotic fluid (mean +/- SEM) (2.2 +/- 0.7 nmol/l vs. 0.6 +/- 0.02 nmol/l, p < 0.05), in umbilical cord plasma (1.2 +/- 0.2 nmol/l vs. 0.7 +/- 0.3 nmol/l, p < 0.05) and in umbilical cord erythrocytes (159.6 +/- 48.6 nmol/g Hb vs. 85.8 +/- 5.2 nmol/g Hb, p < 0.05) in women delivering by emergent cesarean compared to those delivering by elective cesarean. GPX activity was enhanced in amniotic fluid (12.4 +/- 2.2 U/l vs. 5.1 +/- 0.6 U/l, p < 0.05) and GPX activity/hemoglobin ratio was higher in cord blood (22.0 +/- 0.8 U/g Hb vs. 18.7 +/- 0.9 U/g Hb, p < 0.05) in women delivering by emergent cesarean compared to those delivering by elective cesarean. CONCLUSION: Distressed fetuses delivered by emergency cesarean exhibited increased malondialdehyde concentrations, an indicative parameter for oxidative damage, and enhanced GPX activity an antioxidant enzyme, in amniotic fluid and umbilical cord blood compared to non-distressed fetuses delivered by elective cesarean section. This is probably an indication of higher fetal oxidative stress. SN - 1661-7819 UR - https://www.unboundmedicine.com/medline/citation/17377411/Different_degrees_of_fetal_oxidative_stress_in_elective_and_emergent_cesarean_section_ L2 - https://www.karger.com?DOI=10.1159/000100965 DB - PRIME DP - Unbound Medicine ER -