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Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years.
J Allergy Clin Immunol. 2007 Jun; 119(6):1438-44.JA

Abstract

BACKGROUND

The Childhood Asthma Prevention Study was a randomized controlled trial conducted in children with a family history of asthma in whom omega-3 fatty acid supplementation and restriction of dietary omega-6 fatty acids did not prevent asthma, eczema, or atopy at age 5 years.

OBJECTIVE

We sought to examine the relation of all measures of omega-3 and omega-6 polyunsaturated fatty acids with outcomes at age 5 years in the whole birth cohort, regardless of randomization group.

METHODS

Plasma fatty acids were measured at 18 months, 3 years, and 5 years. Compliance with the fatty acid supplements was estimated every 6 months. Dietary intake was assessed at 18 months by means of weighed-food record and at 3 years by means of food-frequency questionnaire. At age 5 years, 516 children were examined for wheeze and eczema (questionnaire) and atopy (skin prick tests, n = 488). Multiple logistic regression was used to evaluate associations between exposures and outcomes.

RESULTS

Plasma levels of omega-3 or omega-6 fatty acids were not associated with wheeze, eczema, or atopy at age 5 years (P = .11-.96). Overall, fatty acid exposure, measured as plasma levels, dietary intake, and compliance with supplements, was not associated with any respiratory or allergic outcomes (P = .35-.59).

CONCLUSION

This observational analysis of the cohort, using the full range of observed variation in omega-3 and omega-6 fatty acid exposure, supports the negative findings of the randomized controlled trial.

CLINICAL IMPLICATIONS

Modification of dietary polyunsaturated fatty acids in early childhood is not helpful in preventing atopy and asthma.

Authors+Show Affiliations

Woolcock Institute of Medical Research, Camperdown NSW, Australia. calmqvist@woolcock.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17379291

Citation

Almqvist, Catarina, et al. "Omega-3 and Omega-6 Fatty Acid Exposure From Early Life Does Not Affect Atopy and Asthma at Age 5 Years." The Journal of Allergy and Clinical Immunology, vol. 119, no. 6, 2007, pp. 1438-44.
Almqvist C, Garden F, Xuan W, et al. Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J Allergy Clin Immunol. 2007;119(6):1438-44.
Almqvist, C., Garden, F., Xuan, W., Mihrshahi, S., Leeder, S. R., Oddy, W., Webb, K., & Marks, G. B. (2007). Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. The Journal of Allergy and Clinical Immunology, 119(6), 1438-44.
Almqvist C, et al. Omega-3 and Omega-6 Fatty Acid Exposure From Early Life Does Not Affect Atopy and Asthma at Age 5 Years. J Allergy Clin Immunol. 2007;119(6):1438-44. PubMed PMID: 17379291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. AU - Almqvist,Catarina, AU - Garden,Frances, AU - Xuan,Wei, AU - Mihrshahi,Seema, AU - Leeder,Steve R, AU - Oddy,Wendy, AU - Webb,Karen, AU - Marks,Guy B, AU - ,, Y1 - 2007/03/26/ PY - 2006/07/21/received PY - 2007/01/24/revised PY - 2007/01/26/accepted PY - 2007/3/24/pubmed PY - 2007/7/28/medline PY - 2007/3/24/entrez SP - 1438 EP - 44 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 119 IS - 6 N2 - BACKGROUND: The Childhood Asthma Prevention Study was a randomized controlled trial conducted in children with a family history of asthma in whom omega-3 fatty acid supplementation and restriction of dietary omega-6 fatty acids did not prevent asthma, eczema, or atopy at age 5 years. OBJECTIVE: We sought to examine the relation of all measures of omega-3 and omega-6 polyunsaturated fatty acids with outcomes at age 5 years in the whole birth cohort, regardless of randomization group. METHODS: Plasma fatty acids were measured at 18 months, 3 years, and 5 years. Compliance with the fatty acid supplements was estimated every 6 months. Dietary intake was assessed at 18 months by means of weighed-food record and at 3 years by means of food-frequency questionnaire. At age 5 years, 516 children were examined for wheeze and eczema (questionnaire) and atopy (skin prick tests, n = 488). Multiple logistic regression was used to evaluate associations between exposures and outcomes. RESULTS: Plasma levels of omega-3 or omega-6 fatty acids were not associated with wheeze, eczema, or atopy at age 5 years (P = .11-.96). Overall, fatty acid exposure, measured as plasma levels, dietary intake, and compliance with supplements, was not associated with any respiratory or allergic outcomes (P = .35-.59). CONCLUSION: This observational analysis of the cohort, using the full range of observed variation in omega-3 and omega-6 fatty acid exposure, supports the negative findings of the randomized controlled trial. CLINICAL IMPLICATIONS: Modification of dietary polyunsaturated fatty acids in early childhood is not helpful in preventing atopy and asthma. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/17379291/Omega_3_and_omega_6_fatty_acid_exposure_from_early_life_does_not_affect_atopy_and_asthma_at_age_5_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(07)00366-1 DB - PRIME DP - Unbound Medicine ER -