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Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 09; 31(4):921-5.PN

Abstract

The involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant action of venlafaxine (dual serotonin and norepinephrine reuptake inhibitor) was investigated in mice. The antidepressant activity was assessed in forced swim test (FST) behavioral paradigm. Total immobility time was registered during the period of 6 min. Venlafaxine produced dose-dependent (4-16 mg/kg, i.p.) reduction in immobility period. The antidepressant-like effect of venlafaxine (8 mg/kg, i.p.) was prevented by pretreatment with l-arginine (750 mg/kg, i.p.) [substrate for nitric oxide synthase (NOS)]. Pretreatment of mice with 7-nitroindazole (7-NI) (25 mg/kg, i.p.) [a specific neuronal nitric oxide synthase (nNOS) inhibitor] produced potentiation of the action of subeffective dose of venlafaxine (2 mg/kg, i.p.). In addition, treatment of mice with methylene blue (10 mg/kg, i.p.) [direct inhibitor of both nitric oxide synthase (NOS) and soluble guanylate cyclase (sGC)] potentiated the effect of venlafaxine (2 mg/kg, i.p.) in the FST. Furthermore, the reduction in the immobility time elicited by venlafaxine (8 mg/kg, i.p.) was also inhibited by pretreatment with sildenafil (5 mg/kg, i.p.) [phosphodiesterase 5 inhibitor]. The various modulators used in the study did not produce any changes in locomotor activity per se. The results demonstrated that the antidepressant-like effect of venlafaxine in the FST involved an interaction with the L-arginine-NO-cGMP pathway.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17379375

Citation

Dhir, Ashish, and S K. Kulkarni. "Involvement of L-arginine-nitric Oxide-cyclic Guanosine Monophosphate Pathway in the Antidepressant-like Effect of Venlafaxine in Mice." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 31, no. 4, 2007, pp. 921-5.
Dhir A, Kulkarni SK. Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(4):921-5.
Dhir, A., & Kulkarni, S. K. (2007). Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry, 31(4), 921-5.
Dhir A, Kulkarni SK. Involvement of L-arginine-nitric Oxide-cyclic Guanosine Monophosphate Pathway in the Antidepressant-like Effect of Venlafaxine in Mice. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):921-5. PubMed PMID: 17379375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice. AU - Dhir,Ashish, AU - Kulkarni,S K, Y1 - 2007/02/20/ PY - 2006/11/16/received PY - 2007/02/09/revised PY - 2007/02/10/accepted PY - 2007/3/24/pubmed PY - 2007/8/4/medline PY - 2007/3/24/entrez SP - 921 EP - 5 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 31 IS - 4 N2 - The involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant action of venlafaxine (dual serotonin and norepinephrine reuptake inhibitor) was investigated in mice. The antidepressant activity was assessed in forced swim test (FST) behavioral paradigm. Total immobility time was registered during the period of 6 min. Venlafaxine produced dose-dependent (4-16 mg/kg, i.p.) reduction in immobility period. The antidepressant-like effect of venlafaxine (8 mg/kg, i.p.) was prevented by pretreatment with l-arginine (750 mg/kg, i.p.) [substrate for nitric oxide synthase (NOS)]. Pretreatment of mice with 7-nitroindazole (7-NI) (25 mg/kg, i.p.) [a specific neuronal nitric oxide synthase (nNOS) inhibitor] produced potentiation of the action of subeffective dose of venlafaxine (2 mg/kg, i.p.). In addition, treatment of mice with methylene blue (10 mg/kg, i.p.) [direct inhibitor of both nitric oxide synthase (NOS) and soluble guanylate cyclase (sGC)] potentiated the effect of venlafaxine (2 mg/kg, i.p.) in the FST. Furthermore, the reduction in the immobility time elicited by venlafaxine (8 mg/kg, i.p.) was also inhibited by pretreatment with sildenafil (5 mg/kg, i.p.) [phosphodiesterase 5 inhibitor]. The various modulators used in the study did not produce any changes in locomotor activity per se. The results demonstrated that the antidepressant-like effect of venlafaxine in the FST involved an interaction with the L-arginine-NO-cGMP pathway. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17379375/Involvement_of_L_arginine_nitric_oxide_cyclic_guanosine_monophosphate_pathway_in_the_antidepressant_like_effect_of_venlafaxine_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00068-1 DB - PRIME DP - Unbound Medicine ER -