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Dietary intakes of flavonols and flavones and coronary heart disease in US women.
Am J Epidemiol 2007; 165(11):1305-13AJ

Abstract

Dietary flavonols and flavones are subgroups of flavonoids that have been suggested to decrease the risk of coronary heart disease (CHD). The authors prospectively evaluated intakes of flavonols and flavones in relation to risk of nonfatal myocardial infarction and fatal CHD in the Nurses' Health Study. They assessed dietary information from the study's 1990, 1994, and 1998 food frequency questionnaires and computed cumulative average intakes of flavonols and flavones. Cox proportional hazards regression with time-varying variables was used for analysis. During 12 years of follow-up (1990-2002), the authors documented 938 nonfatal myocardial infarctions and 324 CHD deaths among 66,360 women. They observed no association between flavonol or flavone intake and risk of nonfatal myocardial infarction or fatal CHD. However, a weak risk reduction for CHD death was found among women with a higher intake of kaempferol, an individual flavonol found primarily in broccoli and tea. Women in the highest quintile of kaempferol intake relative to those in the lowest had a multivariate relative risk of 0.66 (95% confidence interval: 0.48, 0.93; p for trend = 0.04). The lower risk associated with kaempferol intake was probably attributable to broccoli consumption. These prospective data do not support an inverse association between flavonol or flavone intake and CHD risk.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. jhlin@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17379619

Citation

Lin, Jennifer, et al. "Dietary Intakes of Flavonols and Flavones and Coronary Heart Disease in US Women." American Journal of Epidemiology, vol. 165, no. 11, 2007, pp. 1305-13.
Lin J, Rexrode KM, Hu F, et al. Dietary intakes of flavonols and flavones and coronary heart disease in US women. Am J Epidemiol. 2007;165(11):1305-13.
Lin, J., Rexrode, K. M., Hu, F., Albert, C. M., Chae, C. U., Rimm, E. B., ... Manson, J. E. (2007). Dietary intakes of flavonols and flavones and coronary heart disease in US women. American Journal of Epidemiology, 165(11), pp. 1305-13.
Lin J, et al. Dietary Intakes of Flavonols and Flavones and Coronary Heart Disease in US Women. Am J Epidemiol. 2007 Jun 1;165(11):1305-13. PubMed PMID: 17379619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intakes of flavonols and flavones and coronary heart disease in US women. AU - Lin,Jennifer, AU - Rexrode,Kathy M, AU - Hu,Frank, AU - Albert,Christine M, AU - Chae,Claudia U, AU - Rimm,Eric B, AU - Stampfer,Meir J, AU - Manson,JoAnn E, Y1 - 2007/03/22/ PY - 2007/3/24/pubmed PY - 2007/7/14/medline PY - 2007/3/24/entrez SP - 1305 EP - 13 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 165 IS - 11 N2 - Dietary flavonols and flavones are subgroups of flavonoids that have been suggested to decrease the risk of coronary heart disease (CHD). The authors prospectively evaluated intakes of flavonols and flavones in relation to risk of nonfatal myocardial infarction and fatal CHD in the Nurses' Health Study. They assessed dietary information from the study's 1990, 1994, and 1998 food frequency questionnaires and computed cumulative average intakes of flavonols and flavones. Cox proportional hazards regression with time-varying variables was used for analysis. During 12 years of follow-up (1990-2002), the authors documented 938 nonfatal myocardial infarctions and 324 CHD deaths among 66,360 women. They observed no association between flavonol or flavone intake and risk of nonfatal myocardial infarction or fatal CHD. However, a weak risk reduction for CHD death was found among women with a higher intake of kaempferol, an individual flavonol found primarily in broccoli and tea. Women in the highest quintile of kaempferol intake relative to those in the lowest had a multivariate relative risk of 0.66 (95% confidence interval: 0.48, 0.93; p for trend = 0.04). The lower risk associated with kaempferol intake was probably attributable to broccoli consumption. These prospective data do not support an inverse association between flavonol or flavone intake and CHD risk. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17379619/Dietary_intakes_of_flavonols_and_flavones_and_coronary_heart_disease_in_US_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm016 DB - PRIME DP - Unbound Medicine ER -