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Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels.
Ann Biomed Eng. 2007 May; 35(5):755-65.AB

Abstract

A theoretical method is used to simulate the motion and deformation of mammalian red blood cells (RBCs) in microvessels, based on knowledge of the mechanical characteristics of RBCs. Each RBC is represented as a set of interconnected viscoelastic elements in two dimensions. The motion and deformation of the cell and the motion of the surrounding fluid are computed using a finite-element numerical method. Simulations of RBC motion in simple shear flow of a high-viscosity fluid show "tank-treading'' motion of the membrane around the cell perimeter, as observed experimentally. With appropriate choice of the parameters representing RBC mechanical properties, the tank-treading frequency and cell elongation agree closely with observations over a range of shear rates. In simulations of RBC motion in capillary-sized channels, initially circular cell shapes rapidly approach shapes typical of those seen experimentally in capillaries, convex in front and concave at the rear. An isolated RBC entering an 8-mum capillary close to the wall is predicted to migrate in the lateral direction as it traverses the capillary, achieving a position near the center-line after traveling a distance of about 60 mum. Cell trajectories agree closely with those observed in microvessels of the rat mesentery.

Authors+Show Affiliations

Department of Physiology, University of Arizona, Tucson, AZ 85724-5051, USA. secomb@u.arizona.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural
Validation Study

Language

eng

PubMed ID

17380392

Citation

Secomb, Timothy W., et al. "Two-dimensional Simulation of Red Blood Cell Deformation and Lateral Migration in Microvessels." Annals of Biomedical Engineering, vol. 35, no. 5, 2007, pp. 755-65.
Secomb TW, Styp-Rekowska B, Pries AR. Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels. Ann Biomed Eng. 2007;35(5):755-65.
Secomb, T. W., Styp-Rekowska, B., & Pries, A. R. (2007). Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels. Annals of Biomedical Engineering, 35(5), 755-65.
Secomb TW, Styp-Rekowska B, Pries AR. Two-dimensional Simulation of Red Blood Cell Deformation and Lateral Migration in Microvessels. Ann Biomed Eng. 2007;35(5):755-65. PubMed PMID: 17380392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels. AU - Secomb,Timothy W, AU - Styp-Rekowska,Beata, AU - Pries,Axel R, Y1 - 2007/03/23/ PY - 2006/09/05/received PY - 2007/01/29/accepted PY - 2007/3/24/pubmed PY - 2007/6/28/medline PY - 2007/3/24/entrez SP - 755 EP - 65 JF - Annals of biomedical engineering JO - Ann Biomed Eng VL - 35 IS - 5 N2 - A theoretical method is used to simulate the motion and deformation of mammalian red blood cells (RBCs) in microvessels, based on knowledge of the mechanical characteristics of RBCs. Each RBC is represented as a set of interconnected viscoelastic elements in two dimensions. The motion and deformation of the cell and the motion of the surrounding fluid are computed using a finite-element numerical method. Simulations of RBC motion in simple shear flow of a high-viscosity fluid show "tank-treading'' motion of the membrane around the cell perimeter, as observed experimentally. With appropriate choice of the parameters representing RBC mechanical properties, the tank-treading frequency and cell elongation agree closely with observations over a range of shear rates. In simulations of RBC motion in capillary-sized channels, initially circular cell shapes rapidly approach shapes typical of those seen experimentally in capillaries, convex in front and concave at the rear. An isolated RBC entering an 8-mum capillary close to the wall is predicted to migrate in the lateral direction as it traverses the capillary, achieving a position near the center-line after traveling a distance of about 60 mum. Cell trajectories agree closely with those observed in microvessels of the rat mesentery. SN - 0090-6964 UR - https://www.unboundmedicine.com/medline/citation/17380392/Two_dimensional_simulation_of_red_blood_cell_deformation_and_lateral_migration_in_microvessels_ L2 - https://doi.org/10.1007/s10439-007-9275-0 DB - PRIME DP - Unbound Medicine ER -