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Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury.
J Agric Food Chem. 2007 Apr 18; 55(8):2854-60.JA

Abstract

White wines are generally low in polyphenol content as compared to red wines. However, Champagne wines have been shown to contain relatively high amounts of phenolic acids that may exert protective cellular actions in vivo. In this study, we have investigated the potential neuroprotective effects of Champagne wine extracts, and individual phenolics present in these extracts, against peroxynitrite-induced injury. Organic and aqueous Champagne wine extracts exhibited potent neuroprotective activity against peroxynitrite-induced injury at low concentrations (0.1 microg/mL). This protection appeared to be in part due to the cellular actions of individual components found in the organic extracts, notably tyrosol, caffeic acid, and gallic acid. These phenolics were observed to exert potent neuroprotection at concentrations between 0.1 and 10 microM. Together, these data suggest that polyphenols present in Champagne wine may induce a neuroprotective effect against oxidative neuronal injury.

Authors+Show Affiliations

Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P.O. Box 226, Whiteknights, Reading RG6 6AP, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17381112

Citation

Vauzour, David, et al. "Champagne Wine Polyphenols Protect Primary Cortical Neurons Against Peroxynitrite-induced Injury." Journal of Agricultural and Food Chemistry, vol. 55, no. 8, 2007, pp. 2854-60.
Vauzour D, Vafeiadou K, Corona G, et al. Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. J Agric Food Chem. 2007;55(8):2854-60.
Vauzour, D., Vafeiadou, K., Corona, G., Pollard, S. E., Tzounis, X., & Spencer, J. P. (2007). Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. Journal of Agricultural and Food Chemistry, 55(8), 2854-60.
Vauzour D, et al. Champagne Wine Polyphenols Protect Primary Cortical Neurons Against Peroxynitrite-induced Injury. J Agric Food Chem. 2007 Apr 18;55(8):2854-60. PubMed PMID: 17381112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. AU - Vauzour,David, AU - Vafeiadou,Katerina, AU - Corona,Giulia, AU - Pollard,Susan E, AU - Tzounis,Xenofon, AU - Spencer,Jeremy P E, Y1 - 2007/03/24/ PY - 2007/3/27/pubmed PY - 2007/6/8/medline PY - 2007/3/27/entrez SP - 2854 EP - 60 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 55 IS - 8 N2 - White wines are generally low in polyphenol content as compared to red wines. However, Champagne wines have been shown to contain relatively high amounts of phenolic acids that may exert protective cellular actions in vivo. In this study, we have investigated the potential neuroprotective effects of Champagne wine extracts, and individual phenolics present in these extracts, against peroxynitrite-induced injury. Organic and aqueous Champagne wine extracts exhibited potent neuroprotective activity against peroxynitrite-induced injury at low concentrations (0.1 microg/mL). This protection appeared to be in part due to the cellular actions of individual components found in the organic extracts, notably tyrosol, caffeic acid, and gallic acid. These phenolics were observed to exert potent neuroprotection at concentrations between 0.1 and 10 microM. Together, these data suggest that polyphenols present in Champagne wine may induce a neuroprotective effect against oxidative neuronal injury. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/17381112/Champagne_wine_polyphenols_protect_primary_cortical_neurons_against_peroxynitrite_induced_injury_ L2 - https://dx.doi.org/10.1021/jf063304z DB - PRIME DP - Unbound Medicine ER -