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Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial.
J Agric Food Chem. 2007 Apr 18; 55(8):3217-24.JA

Abstract

This study assessed the effect of an 8 week consumption of dried cranberry juice (DCJ) on 65 healthy young women. Basic biochemical and hematological parameters, antioxidant status, presence of metabolites in urine, and urine ex vivo antiadherence activity were determined throughout the trial. A 400 mg amount of DCJ/day had no influence on any parameter tested. A 1200 mg amount of DCJ/day resulted in a statistically significant decrease in serum levels of advanced oxidation protein products. This specific protective effect against oxidative damage of proteins is described here for the first time. Urine samples had an inhibitory effect on the adhesion of uropathogenic Escherichia coli strains, but no increase in urine acidity was noted. Hippuric acid, isomers of salicyluric and dihydroxybenzoic acids, and quercetin glucuronide were identified as the main metabolites. In conclusion, cranberry fruits are effective not only in the prevention of urinary tract infection but also for the prevention of oxidative stress.

Authors+Show Affiliations

Departments of Medical Chemistry and Biochemistry and Microbiology, Faculty of Medicine and Dentistry, Palacký University, HnevotínskA 3, CZ-77515 Olomouc, Czech Republic. kata.valentova@email.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17381122

Citation

Valentova, Katerina, et al. "Biosafety, Antioxidant Status, and Metabolites in Urine After Consumption of Dried Cranberry Juice in Healthy Women: a Pilot Double-blind Placebo-controlled Trial." Journal of Agricultural and Food Chemistry, vol. 55, no. 8, 2007, pp. 3217-24.
Valentova K, Stejskal D, Bednar P, et al. Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. J Agric Food Chem. 2007;55(8):3217-24.
Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cíhalík, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., & Simanek, V. (2007). Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. Journal of Agricultural and Food Chemistry, 55(8), 3217-24.
Valentova K, et al. Biosafety, Antioxidant Status, and Metabolites in Urine After Consumption of Dried Cranberry Juice in Healthy Women: a Pilot Double-blind Placebo-controlled Trial. J Agric Food Chem. 2007 Apr 18;55(8):3217-24. PubMed PMID: 17381122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. AU - Valentova,Katerina, AU - Stejskal,David, AU - Bednar,Petr, AU - Vostalova,Jitka, AU - Cíhalík,Cestmír, AU - Vecerova,Renata, AU - Koukalova,Dagmar, AU - Kolar,Milan, AU - Reichenbach,Richard, AU - Sknouril,Lucyna, AU - Ulrichova,Jitka, AU - Simanek,Vilím, Y1 - 2007/03/24/ PY - 2007/3/27/pubmed PY - 2007/6/8/medline PY - 2007/3/27/entrez SP - 3217 EP - 24 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 55 IS - 8 N2 - This study assessed the effect of an 8 week consumption of dried cranberry juice (DCJ) on 65 healthy young women. Basic biochemical and hematological parameters, antioxidant status, presence of metabolites in urine, and urine ex vivo antiadherence activity were determined throughout the trial. A 400 mg amount of DCJ/day had no influence on any parameter tested. A 1200 mg amount of DCJ/day resulted in a statistically significant decrease in serum levels of advanced oxidation protein products. This specific protective effect against oxidative damage of proteins is described here for the first time. Urine samples had an inhibitory effect on the adhesion of uropathogenic Escherichia coli strains, but no increase in urine acidity was noted. Hippuric acid, isomers of salicyluric and dihydroxybenzoic acids, and quercetin glucuronide were identified as the main metabolites. In conclusion, cranberry fruits are effective not only in the prevention of urinary tract infection but also for the prevention of oxidative stress. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/17381122/Biosafety_antioxidant_status_and_metabolites_in_urine_after_consumption_of_dried_cranberry_juice_in_healthy_women:_a_pilot_double_blind_placebo_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -