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Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study.
Clin Endocrinol (Oxf). 2007 May; 66(5):666-71.CE

Abstract

OBJECTIVE

The metabolic syndrome has been associated with increased mortality in some Caucasian populations, but data in Asian populations are not available. We present data describing the association of the metabolic syndrome with mortality.

METHODS

The impact of the US National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) metabolic syndrome guidelines definition (using Asian central obesity criteria) on mortality was examined using Cox regression analyses in a population-based cohort (n = 2863) of Chinese subjects.

RESULTS

The cohort was followed up for a mean duration of 8.45 years, a total of 24 101 person-years, with 89 deaths (33.7% of vascular origin). Compared to those without any component of the metabolic syndrome, following adjustment for age, socioeconomic status and a range of lifestyle habits, those with the metabolic syndrome had increased risk of both all-cause [hazard ratio (HR) 2.02, 95% confidence interval (CI) 1.02-4.00, P for trend = 0.037] and vascular disease (HR 6.39, 95% CI 1.40-29.2, P < 0.05, P for trend = 0.002) mortality. When those with 0-2 components were compared to those with the metabolic syndrome, the HRs were 1.49 (95% CI 0.95-2.33, P = 0.084) and 3.36 (95% CI 1.57-7.19, P = 0.002), respectively.

CONCLUSION

This study shows that the metabolic syndrome is associated with increased mortality risk in an Asian population. The high prevalence of the metabolic syndrome, particularly in the elderly, forewarns of a rapidly increasing problem in mainland China, and other Asian populations, which could have overwhelming public health ramifications.

Authors+Show Affiliations

Department of Community Medicine, The University of Hong Kong, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17381490

Citation

Thomas, G Neil, et al. "Metabolic Syndrome Increases All-cause and Vascular Mortality: the Hong Kong Cardiovascular Risk Factor Study." Clinical Endocrinology, vol. 66, no. 5, 2007, pp. 666-71.
Thomas GN, Schooling CM, McGhee SM, et al. Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clin Endocrinol (Oxf). 2007;66(5):666-71.
Thomas, G. N., Schooling, C. M., McGhee, S. M., Ho, S. Y., Cheung, B. M., Wat, N. M., Janus, E. D., Lam, K. S., & Lam, T. H. (2007). Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clinical Endocrinology, 66(5), 666-71.
Thomas GN, et al. Metabolic Syndrome Increases All-cause and Vascular Mortality: the Hong Kong Cardiovascular Risk Factor Study. Clin Endocrinol (Oxf). 2007;66(5):666-71. PubMed PMID: 17381490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. AU - Thomas,G Neil, AU - Schooling,C Mary, AU - McGhee,Sarah M, AU - Ho,Sai-Yin, AU - Cheung,Bernard M Y, AU - Wat,Nelson M S, AU - Janus,Edward D, AU - Lam,Karen S L, AU - Lam,Tai Hing, AU - ,, Y1 - 2007/03/23/ PY - 2007/3/27/pubmed PY - 2007/9/27/medline PY - 2007/3/27/entrez SP - 666 EP - 71 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 66 IS - 5 N2 - OBJECTIVE: The metabolic syndrome has been associated with increased mortality in some Caucasian populations, but data in Asian populations are not available. We present data describing the association of the metabolic syndrome with mortality. METHODS: The impact of the US National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) metabolic syndrome guidelines definition (using Asian central obesity criteria) on mortality was examined using Cox regression analyses in a population-based cohort (n = 2863) of Chinese subjects. RESULTS: The cohort was followed up for a mean duration of 8.45 years, a total of 24 101 person-years, with 89 deaths (33.7% of vascular origin). Compared to those without any component of the metabolic syndrome, following adjustment for age, socioeconomic status and a range of lifestyle habits, those with the metabolic syndrome had increased risk of both all-cause [hazard ratio (HR) 2.02, 95% confidence interval (CI) 1.02-4.00, P for trend = 0.037] and vascular disease (HR 6.39, 95% CI 1.40-29.2, P < 0.05, P for trend = 0.002) mortality. When those with 0-2 components were compared to those with the metabolic syndrome, the HRs were 1.49 (95% CI 0.95-2.33, P = 0.084) and 3.36 (95% CI 1.57-7.19, P = 0.002), respectively. CONCLUSION: This study shows that the metabolic syndrome is associated with increased mortality risk in an Asian population. The high prevalence of the metabolic syndrome, particularly in the elderly, forewarns of a rapidly increasing problem in mainland China, and other Asian populations, which could have overwhelming public health ramifications. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/17381490/Metabolic_syndrome_increases_all_cause_and_vascular_mortality:_the_Hong_Kong_Cardiovascular_Risk_Factor_Study_ L2 - https://doi.org/10.1111/j.1365-2265.2007.02798.x DB - PRIME DP - Unbound Medicine ER -