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The metabolic syndrome and incidence of cardiovascular disease in non-diabetic subjects--a population-based study comparing three different definitions.
Diabet Med. 2007 May; 24(5):464-72.DM

Abstract

AIMS

Between 1998 and 2005, a number of definitions of the metabolic syndrome (MetS) have been proposed. The aim of this population-based cohort study was to compare prevalence rates and the prediction of cardiovascular disease (CVD) using different definitions of MetS.

METHODS

A total of 5047 non-diabetic subjects (66% women), from the city of Malmö, Sweden, were followed. The incidence of fatal and non-fatal CVD (cardiac events, n = 176, and stroke, n = 171) was monitored over 11 years of follow-up. MetS was defined in three different ways [by International Diabetes Federation (IDF), National Cholesterol Education Program--Adult Treatment Panel III (NCEP-ATPIII), or European Group for the study of Insulin Resistance (EGIR) criteria] based on data on waist circumference, blood pressure, serum triglycerides, High-density lipoprotein cholesterol and fasting blood glucose. The IDF definition identified 21.9% of the subjects having the MetS. Corresponding figures for the NCEP-ATPIII and EGIR definitions were 20.7 and 18.8%, respectively.

RESULTS

After taking age, gender, low-density lipoprotein cholesterol and lifestyle factors into account, the hazard ratio (HR) for CVD event according to the IDF, NCEP-ATPIII and EGIR definitions were HR 1.11 (95% CI: 0.86-1.44), 1.59 (1.25-2.03) and 1.35 (1.05-1.74), respectively. The results were largely similar for cardiac and stroke events.

CONCLUSIONS

The prevalence of Mets according to the IDF definition was higher in comparison with NCEP-ATPIII and EGIR definitions, but the IDF definition was not superior to these definitions for prediction of CVD events. This was true for both genders and questions the usefulness of the current IDF criteria of MetS in a North-European, Caucasian population. In addition, single risk factors such as smoking had an equal prediction as the metabolic syndrome.

Authors+Show Affiliations

Section of Medicine, Department of Clinical Sciences Medicine, University Hospital, Malmö, Sweden. Peter.Nilsson@med.lu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17381496

Citation

Nilsson, P M., et al. "The Metabolic Syndrome and Incidence of Cardiovascular Disease in Non-diabetic Subjects--a Population-based Study Comparing Three Different Definitions." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 24, no. 5, 2007, pp. 464-72.
Nilsson PM, Engström G, Hedblad B. The metabolic syndrome and incidence of cardiovascular disease in non-diabetic subjects--a population-based study comparing three different definitions. Diabet Med. 2007;24(5):464-72.
Nilsson, P. M., Engström, G., & Hedblad, B. (2007). The metabolic syndrome and incidence of cardiovascular disease in non-diabetic subjects--a population-based study comparing three different definitions. Diabetic Medicine : a Journal of the British Diabetic Association, 24(5), 464-72.
Nilsson PM, Engström G, Hedblad B. The Metabolic Syndrome and Incidence of Cardiovascular Disease in Non-diabetic Subjects--a Population-based Study Comparing Three Different Definitions. Diabet Med. 2007;24(5):464-72. PubMed PMID: 17381496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The metabolic syndrome and incidence of cardiovascular disease in non-diabetic subjects--a population-based study comparing three different definitions. AU - Nilsson,P M, AU - Engström,G, AU - Hedblad,B, Y1 - 2007/03/22/ PY - 2007/3/27/pubmed PY - 2007/9/27/medline PY - 2007/3/27/entrez SP - 464 EP - 72 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 24 IS - 5 N2 - AIMS: Between 1998 and 2005, a number of definitions of the metabolic syndrome (MetS) have been proposed. The aim of this population-based cohort study was to compare prevalence rates and the prediction of cardiovascular disease (CVD) using different definitions of MetS. METHODS: A total of 5047 non-diabetic subjects (66% women), from the city of Malmö, Sweden, were followed. The incidence of fatal and non-fatal CVD (cardiac events, n = 176, and stroke, n = 171) was monitored over 11 years of follow-up. MetS was defined in three different ways [by International Diabetes Federation (IDF), National Cholesterol Education Program--Adult Treatment Panel III (NCEP-ATPIII), or European Group for the study of Insulin Resistance (EGIR) criteria] based on data on waist circumference, blood pressure, serum triglycerides, High-density lipoprotein cholesterol and fasting blood glucose. The IDF definition identified 21.9% of the subjects having the MetS. Corresponding figures for the NCEP-ATPIII and EGIR definitions were 20.7 and 18.8%, respectively. RESULTS: After taking age, gender, low-density lipoprotein cholesterol and lifestyle factors into account, the hazard ratio (HR) for CVD event according to the IDF, NCEP-ATPIII and EGIR definitions were HR 1.11 (95% CI: 0.86-1.44), 1.59 (1.25-2.03) and 1.35 (1.05-1.74), respectively. The results were largely similar for cardiac and stroke events. CONCLUSIONS: The prevalence of Mets according to the IDF definition was higher in comparison with NCEP-ATPIII and EGIR definitions, but the IDF definition was not superior to these definitions for prediction of CVD events. This was true for both genders and questions the usefulness of the current IDF criteria of MetS in a North-European, Caucasian population. In addition, single risk factors such as smoking had an equal prediction as the metabolic syndrome. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17381496/The_metabolic_syndrome_and_incidence_of_cardiovascular_disease_in_non_diabetic_subjects__a_population_based_study_comparing_three_different_definitions_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02142.x DB - PRIME DP - Unbound Medicine ER -