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Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis.
J Helminthol. 2007 Mar; 81(1):1-5.JH

Abstract

Angiostrongylus cantonensis can invade the central nervous system, leading to human eosinophilic meningitis or eosinophilic meningoencephalitis. Curcumin is a natural product which has the effects of anti-inflammation, anti-oxidation and anti-carcinogensis, while the administration of curcumin has been reported to possibly relieve the symptoms of meningitis. The present study tested the potential efficacy of curcumin in A. cantonensis-induced eosinophilic meningitis of BALB/c mice. Assay indicators for the therapeutic effect included the larvicidal effect, eosinophil counts and matrix metalloproteinase-9 (MMP-9) activity in angiostrongyliasis. Eosinophils were mildly reduced in treatment groups compared with infected-untreated mice. However, there were no significant differences in larvicidal effects or MMP-9 activity. This study suggests that anti-inflammatory treatment with curcumin alone has low efficacy, but the treatment does not interfere with MMP-9 expression and is not useful for larvicidal effects. The possible reasons include low curcumin across the blood-brain barrier and also those larvae that survive stimulate MMP-9 production, which promotes blood-brain barrier damage, with leukocytes then crossing the blood-brain barrier to cause meningitis. Further studies will be required to test these possibilities.

Authors+Show Affiliations

Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan. shih@csmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17381860

Citation

Shih, P C., et al. "Efficacy of Curcumin Therapy Against Angiostrongylus Cantonensis-induced Eosinophilic Meningitis." Journal of Helminthology, vol. 81, no. 1, 2007, pp. 1-5.
Shih PC, Lee HH, Lai SC, et al. Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. J Helminthol. 2007;81(1):1-5.
Shih, P. C., Lee, H. H., Lai, S. C., Chen, K. M., Jiang, S. T., Chen, Y. F., & Shiow, S. J. (2007). Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. Journal of Helminthology, 81(1), 1-5.
Shih PC, et al. Efficacy of Curcumin Therapy Against Angiostrongylus Cantonensis-induced Eosinophilic Meningitis. J Helminthol. 2007;81(1):1-5. PubMed PMID: 17381860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. AU - Shih,P C, AU - Lee,H H, AU - Lai,S C, AU - Chen,K M, AU - Jiang,S T, AU - Chen,Y F, AU - Shiow,S J, PY - 2007/3/27/pubmed PY - 2007/8/19/medline PY - 2007/3/27/entrez SP - 1 EP - 5 JF - Journal of helminthology JO - J Helminthol VL - 81 IS - 1 N2 - Angiostrongylus cantonensis can invade the central nervous system, leading to human eosinophilic meningitis or eosinophilic meningoencephalitis. Curcumin is a natural product which has the effects of anti-inflammation, anti-oxidation and anti-carcinogensis, while the administration of curcumin has been reported to possibly relieve the symptoms of meningitis. The present study tested the potential efficacy of curcumin in A. cantonensis-induced eosinophilic meningitis of BALB/c mice. Assay indicators for the therapeutic effect included the larvicidal effect, eosinophil counts and matrix metalloproteinase-9 (MMP-9) activity in angiostrongyliasis. Eosinophils were mildly reduced in treatment groups compared with infected-untreated mice. However, there were no significant differences in larvicidal effects or MMP-9 activity. This study suggests that anti-inflammatory treatment with curcumin alone has low efficacy, but the treatment does not interfere with MMP-9 expression and is not useful for larvicidal effects. The possible reasons include low curcumin across the blood-brain barrier and also those larvae that survive stimulate MMP-9 production, which promotes blood-brain barrier damage, with leukocytes then crossing the blood-brain barrier to cause meningitis. Further studies will be required to test these possibilities. SN - 0022-149X UR - https://www.unboundmedicine.com/medline/citation/17381860/Efficacy_of_curcumin_therapy_against_Angiostrongylus_cantonensis_induced_eosinophilic_meningitis_ L2 - https://www.cambridge.org/core/product/identifier/S0022149X07182353/type/journal_article DB - PRIME DP - Unbound Medicine ER -