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Calcium, diet and fracture risk: a prospective study of 1898 incident fractures among 34 696 British women and men.
Public Health Nutr 2007; 10(11):1314-20PH

Abstract

OBJECTIVE

The risk factors for fractures are incompletely understood. An outstanding question concerns the optimal amount of dietary calcium needed to minimise the risk of fracture.

DESIGN

We examined the associations of dietary calcium and other nutrients with self-reported fracture risk in a prospective cohort study. Nutrient intakes were estimated using a semi-quantitative food-frequency questionnaire administered at recruitment.

SETTING

The UK.

PARTICIPANTS

A total of 26 749 women and 7947 men aged 20-89 years.

RESULTS

Over an average of 5.2 years of follow-up, 1555 women and 343 men reported one or more fractures, 72% of these resulting from a fall. Among women, fracture risk was higher at lower calcium intakes, with a relative risk of 1.75 (95% confidence interval (CI) 1.33-2.29) among women with a calcium intake of < 525 mg day- 1 compared with women with a calcium intake of at least 1200 mg day- 1 (test for linear trend, P < 0.001). The association of dietary calcium with fracture risk was stronger among women aged under 50 years at recruitment than among women aged 50 and above. Dietary calcium intake was not associated with fracture risk in men. Fracture risk was not related to the dietary intake of any other nutrient examined.

CONCLUSION

In this population, women with a low dietary calcium intake had an increased risk of bone fracture, and this association was more marked among younger women than among older women.

Authors+Show Affiliations

Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK. tim.key@ceu.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17381900

Citation

Key, Timothy J., et al. "Calcium, Diet and Fracture Risk: a Prospective Study of 1898 Incident Fractures Among 34 696 British Women and Men." Public Health Nutrition, vol. 10, no. 11, 2007, pp. 1314-20.
Key TJ, Appleby PN, Spencer EA, et al. Calcium, diet and fracture risk: a prospective study of 1898 incident fractures among 34 696 British women and men. Public Health Nutr. 2007;10(11):1314-20.
Key, T. J., Appleby, P. N., Spencer, E. A., Roddam, A. W., Neale, R. E., & Allen, N. E. (2007). Calcium, diet and fracture risk: a prospective study of 1898 incident fractures among 34 696 British women and men. Public Health Nutrition, 10(11), pp. 1314-20.
Key TJ, et al. Calcium, Diet and Fracture Risk: a Prospective Study of 1898 Incident Fractures Among 34 696 British Women and Men. Public Health Nutr. 2007;10(11):1314-20. PubMed PMID: 17381900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium, diet and fracture risk: a prospective study of 1898 incident fractures among 34 696 British women and men. AU - Key,Timothy J, AU - Appleby,Paul N, AU - Spencer,Elizabeth A, AU - Roddam,Andrew W, AU - Neale,Rachel E, AU - Allen,Naomi E, Y1 - 2007/03/19/ PY - 2007/3/27/pubmed PY - 2008/1/25/medline PY - 2007/3/27/entrez SP - 1314 EP - 20 JF - Public health nutrition JO - Public Health Nutr VL - 10 IS - 11 N2 - OBJECTIVE: The risk factors for fractures are incompletely understood. An outstanding question concerns the optimal amount of dietary calcium needed to minimise the risk of fracture. DESIGN: We examined the associations of dietary calcium and other nutrients with self-reported fracture risk in a prospective cohort study. Nutrient intakes were estimated using a semi-quantitative food-frequency questionnaire administered at recruitment. SETTING: The UK. PARTICIPANTS: A total of 26 749 women and 7947 men aged 20-89 years. RESULTS: Over an average of 5.2 years of follow-up, 1555 women and 343 men reported one or more fractures, 72% of these resulting from a fall. Among women, fracture risk was higher at lower calcium intakes, with a relative risk of 1.75 (95% confidence interval (CI) 1.33-2.29) among women with a calcium intake of < 525 mg day- 1 compared with women with a calcium intake of at least 1200 mg day- 1 (test for linear trend, P < 0.001). The association of dietary calcium with fracture risk was stronger among women aged under 50 years at recruitment than among women aged 50 and above. Dietary calcium intake was not associated with fracture risk in men. Fracture risk was not related to the dietary intake of any other nutrient examined. CONCLUSION: In this population, women with a low dietary calcium intake had an increased risk of bone fracture, and this association was more marked among younger women than among older women. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/17381900/Calcium_diet_and_fracture_risk:_a_prospective_study_of_1898_incident_fractures_among_34_696_British_women_and_men_ L2 - https://www.cambridge.org/core/product/identifier/S1368980007696402/type/journal_article DB - PRIME DP - Unbound Medicine ER -