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Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children.
J Pediatr. 2007 Apr; 150(4):383-7.JPed

Abstract

OBJECTIVE

We studied the relationship between % body fat (%BF), cardiovascular fitness (CVF), and insulin resistance (IR) in overweight middle-school children.

STUDY DESIGN

Middle school children (n = 106, body mass index [BMI] > 95th percentile for age) underwent evaluation of body composition, maximal volume of oxygen utilization (VO2) uptake/kg lean body mass (VO2max/kgLBM), and fasting glucose and insulin (FI) concentrations and derived homeostasis model assessment index (HOMA(IR)).

RESULTS

Both %BF (r = .33, P < .001) and VO2max/kgLBM (r = -0.42, P < .0001) were significantly correlated with FI. Bivariate regression analysis revealed %BF (P = .008 vs FI, P = .035 vs HOMA(IR)) and VO2max/kgLBM (P < .001 vs FI, P = .009 vs HOMA(IR)) to be independent predictors of insulin sensitivity. In males, VO2max/kgLBM was a better predictor of FI and HOMA(IR) than %BF.

CONCLUSIONS

In obese middle-school children, both %BF and VO2max/kgLBM are independent predictors of FI levels. The relationship between CVF and FI levels was significant in both sexes but was particularly profound and stronger than %BF in males. Efforts to reduce risk of type 2 diabetes mellitus in an increasingly obese child population should include exercise intervention sustained enough to improve CVF.

Authors+Show Affiliations

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison 53792, USA. dballen@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17382115

Citation

Allen, David B., et al. "Fitness Is a Stronger Predictor of Fasting Insulin Levels Than Fatness in Overweight Male Middle-school Children." The Journal of Pediatrics, vol. 150, no. 4, 2007, pp. 383-7.
Allen DB, Nemeth BA, Clark RR, et al. Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children. J Pediatr. 2007;150(4):383-7.
Allen, D. B., Nemeth, B. A., Clark, R. R., Peterson, S. E., Eickhoff, J., & Carrel, A. L. (2007). Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children. The Journal of Pediatrics, 150(4), 383-7.
Allen DB, et al. Fitness Is a Stronger Predictor of Fasting Insulin Levels Than Fatness in Overweight Male Middle-school Children. J Pediatr. 2007;150(4):383-7. PubMed PMID: 17382115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children. AU - Allen,David B, AU - Nemeth,Blaise A, AU - Clark,R Randall, AU - Peterson,Susan E, AU - Eickhoff,Jens, AU - Carrel,Aaron L, PY - 2006/08/06/received PY - 2006/11/08/revised PY - 2006/12/22/accepted PY - 2007/3/27/pubmed PY - 2007/4/12/medline PY - 2007/3/27/entrez SP - 383 EP - 7 JF - The Journal of pediatrics JO - J. Pediatr. VL - 150 IS - 4 N2 - OBJECTIVE: We studied the relationship between % body fat (%BF), cardiovascular fitness (CVF), and insulin resistance (IR) in overweight middle-school children. STUDY DESIGN: Middle school children (n = 106, body mass index [BMI] > 95th percentile for age) underwent evaluation of body composition, maximal volume of oxygen utilization (VO2) uptake/kg lean body mass (VO2max/kgLBM), and fasting glucose and insulin (FI) concentrations and derived homeostasis model assessment index (HOMA(IR)). RESULTS: Both %BF (r = .33, P < .001) and VO2max/kgLBM (r = -0.42, P < .0001) were significantly correlated with FI. Bivariate regression analysis revealed %BF (P = .008 vs FI, P = .035 vs HOMA(IR)) and VO2max/kgLBM (P < .001 vs FI, P = .009 vs HOMA(IR)) to be independent predictors of insulin sensitivity. In males, VO2max/kgLBM was a better predictor of FI and HOMA(IR) than %BF. CONCLUSIONS: In obese middle-school children, both %BF and VO2max/kgLBM are independent predictors of FI levels. The relationship between CVF and FI levels was significant in both sexes but was particularly profound and stronger than %BF in males. Efforts to reduce risk of type 2 diabetes mellitus in an increasingly obese child population should include exercise intervention sustained enough to improve CVF. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/17382115/Fitness_is_a_stronger_predictor_of_fasting_insulin_levels_than_fatness_in_overweight_male_middle_school_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(07)00005-4 DB - PRIME DP - Unbound Medicine ER -