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PKC blockade differentially affects aversive but not appetitive gustatory memories.
Brain Res. 2007 May 07; 1148:177-82.BR

Abstract

After consumption of a new taste, there are mainly two possible outcomes for the establishment of a taste memory, either it will be aversive or safe depending on the consequences of taste consumption. It has been proposed that both types of learning share a common initial taste memory trace, which will lead to two different memory traces, safe or aversive. To study the role of PKC activity in aversive or safe taste memory formation, we administered chelerythrine, a PKC inhibitor, into the insular cortex or parietal cortex 20 min before conditioned taste aversion or attenuation of neophobia training. The results suggest that PKC activity is needed in the insular cortex for the establishment of aversive taste memory, but not for safe taste memory.

Authors+Show Affiliations

Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510 México DF, Mexico.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17382303

Citation

Núñez-Jaramillo, Luis, et al. "PKC Blockade Differentially Affects Aversive but Not Appetitive Gustatory Memories." Brain Research, vol. 1148, 2007, pp. 177-82.
Núñez-Jaramillo L, Delint-Ramirez I, Bermúdez-Rattoni F. PKC blockade differentially affects aversive but not appetitive gustatory memories. Brain Res. 2007;1148:177-82.
Núñez-Jaramillo, L., Delint-Ramirez, I., & Bermúdez-Rattoni, F. (2007). PKC blockade differentially affects aversive but not appetitive gustatory memories. Brain Research, 1148, 177-82.
Núñez-Jaramillo L, Delint-Ramirez I, Bermúdez-Rattoni F. PKC Blockade Differentially Affects Aversive but Not Appetitive Gustatory Memories. Brain Res. 2007 May 7;1148:177-82. PubMed PMID: 17382303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PKC blockade differentially affects aversive but not appetitive gustatory memories. AU - Núñez-Jaramillo,Luis, AU - Delint-Ramirez,Ilse, AU - Bermúdez-Rattoni,Federico, Y1 - 2007/02/24/ PY - 2006/09/21/received PY - 2007/02/04/revised PY - 2007/02/14/accepted PY - 2007/3/27/pubmed PY - 2007/7/26/medline PY - 2007/3/27/entrez SP - 177 EP - 82 JF - Brain research JO - Brain Res VL - 1148 N2 - After consumption of a new taste, there are mainly two possible outcomes for the establishment of a taste memory, either it will be aversive or safe depending on the consequences of taste consumption. It has been proposed that both types of learning share a common initial taste memory trace, which will lead to two different memory traces, safe or aversive. To study the role of PKC activity in aversive or safe taste memory formation, we administered chelerythrine, a PKC inhibitor, into the insular cortex or parietal cortex 20 min before conditioned taste aversion or attenuation of neophobia training. The results suggest that PKC activity is needed in the insular cortex for the establishment of aversive taste memory, but not for safe taste memory. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/17382303/PKC_blockade_differentially_affects_aversive_but_not_appetitive_gustatory_memories_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(07)00421-0 DB - PRIME DP - Unbound Medicine ER -