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Effects of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats.
Chem Biol Interact. 2007 Apr 25; 167(2):145-52.CB

Abstract

The present study was aimed to investigate the effects of ethylene glycol (EG) on serum marker enzymes, antioxidant defense systems and lipid peroxidation concentration (malondialdehyde=MDA) in various tissues of rats exposed to ethylene glycol. EG (1.25% or 2.5%) in drinking water was administered orally to rats (Sprague-Dawley albino) ad libitum for 21 days continuously. EG treatments caused different effects on the serum marker enzymes, antioxidant defense system and MDA content in various tissues of the treatment groups as compared with the controls. EG also caused a significant increase in the serum marker enzyme activities with 2.5% dosage whereas, no changes were not observed with 1.25% dosage of EG treatment. Lipid peroxidation significantly increased in all the tissues except for in the heart and stomach of rats treated with both dosages of EG. Also, the antioxidative systems were also seriously affected by EG. For example, SOD significantly decreased in the liver treated with both dosages whereas, SOD activity in the erythrocytes, kidney, heart and stomach were significantly increased and not changed in the brain with two dosages of EG. Also, while CAT activity significantly decreased in the erythrocytes, liver and kidney, the activity in the stomach significantly increased, but did not change in the brain and heart with two doses of EG. GR activity significantly decreased in the erythrocytes treated with both dosages of EG whereas GR was not affected in other tissues by EG treatment. GST activity significantly elevated in the heart and brain but did not change in the other tissues of rats treated with both dosages of EG. Meanwhile, GSH depletion in the erythrocytes of rats treated with 2.5% dosage of EG was found to be significant whereas, the level of GSH in the brain was significantly increased treated with both the dosages of EG. The observations presented led us to conclude that the administration of subacute EG promotes lipid peroxidatin content, elevates tissue damage serum marker enzymes and changes in the antioxidative systems in rats. These data, along with the determined changes suggest that EG produced substantial systemic organ toxicity in the erythrocyte, liver, brain, heart kidney and stomach during the period of a 21-day subacute exposure.

Authors+Show Affiliations

Department of Biology, Faculty of Arts and Sciences, Yüzüncü Yil University, 65080 Van, Turkey. icelik65@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17382310

Citation

Celik, Ismail, and Huseyin Suzek. "Effects of Subacute Treatment of Ethylene Glycol On Serum Marker Enzymes and Erythrocyte and Tissue Antioxidant Defense Systems and Lipid Peroxidation in Rats." Chemico-biological Interactions, vol. 167, no. 2, 2007, pp. 145-52.
Celik I, Suzek H. Effects of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Chem Biol Interact. 2007;167(2):145-52.
Celik, I., & Suzek, H. (2007). Effects of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Chemico-biological Interactions, 167(2), 145-52.
Celik I, Suzek H. Effects of Subacute Treatment of Ethylene Glycol On Serum Marker Enzymes and Erythrocyte and Tissue Antioxidant Defense Systems and Lipid Peroxidation in Rats. Chem Biol Interact. 2007 Apr 25;167(2):145-52. PubMed PMID: 17382310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. AU - Celik,Ismail, AU - Suzek,Huseyin, Y1 - 2007/02/20/ PY - 2006/12/11/received PY - 2007/02/07/revised PY - 2007/02/07/accepted PY - 2007/3/27/pubmed PY - 2007/6/1/medline PY - 2007/3/27/entrez SP - 145 EP - 52 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 167 IS - 2 N2 - The present study was aimed to investigate the effects of ethylene glycol (EG) on serum marker enzymes, antioxidant defense systems and lipid peroxidation concentration (malondialdehyde=MDA) in various tissues of rats exposed to ethylene glycol. EG (1.25% or 2.5%) in drinking water was administered orally to rats (Sprague-Dawley albino) ad libitum for 21 days continuously. EG treatments caused different effects on the serum marker enzymes, antioxidant defense system and MDA content in various tissues of the treatment groups as compared with the controls. EG also caused a significant increase in the serum marker enzyme activities with 2.5% dosage whereas, no changes were not observed with 1.25% dosage of EG treatment. Lipid peroxidation significantly increased in all the tissues except for in the heart and stomach of rats treated with both dosages of EG. Also, the antioxidative systems were also seriously affected by EG. For example, SOD significantly decreased in the liver treated with both dosages whereas, SOD activity in the erythrocytes, kidney, heart and stomach were significantly increased and not changed in the brain with two dosages of EG. Also, while CAT activity significantly decreased in the erythrocytes, liver and kidney, the activity in the stomach significantly increased, but did not change in the brain and heart with two doses of EG. GR activity significantly decreased in the erythrocytes treated with both dosages of EG whereas GR was not affected in other tissues by EG treatment. GST activity significantly elevated in the heart and brain but did not change in the other tissues of rats treated with both dosages of EG. Meanwhile, GSH depletion in the erythrocytes of rats treated with 2.5% dosage of EG was found to be significant whereas, the level of GSH in the brain was significantly increased treated with both the dosages of EG. The observations presented led us to conclude that the administration of subacute EG promotes lipid peroxidatin content, elevates tissue damage serum marker enzymes and changes in the antioxidative systems in rats. These data, along with the determined changes suggest that EG produced substantial systemic organ toxicity in the erythrocyte, liver, brain, heart kidney and stomach during the period of a 21-day subacute exposure. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/17382310/Effects_of_subacute_treatment_of_ethylene_glycol_on_serum_marker_enzymes_and_erythrocyte_and_tissue_antioxidant_defense_systems_and_lipid_peroxidation_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(07)00042-7 DB - PRIME DP - Unbound Medicine ER -