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Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers.
Psychiatry Res. 2007 Jul 30; 152(1):1-10.PR

Abstract

Low dietary intake of omega-3 polyunsaturated fatty acids has been linked to several features of psychiatric symptomatology, including depression, disorders of impulse control, and hostility. Preliminary intervention trials of omega-3 fatty acid supplementation for clinical depression and other disorders have reported benefit. However, few studies have investigated the relationships between these fatty acids and normative variability in mood, behavior and personality. Participants were 105 hypercholesterolemic, but otherwise healthy, non-smoking adults. Fasting serum alpha-linolenic (alpha-LNA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) were assayed with gas chromatography. Participants completed the Beck Depression Inventory (BDI), the NEO Five Factor Personality Inventory (NEO-FFI) and the Barratt Impulsiveness Scale (BIS). In multivariate analyses, higher levels of the long chain omega-3 PUFAs, EPA and DHA, were associated with significantly reduced odds of scoring >or=10 on the BDI. Similarly, DHA and EPA covaried inversely with NEO-Neuroticism scores, whereas DHA was positively associated with NEO-Agreeableness. On the BIS, DHA was inversely related to cognitive impulsivity and alpha-LNA was inversely related to motor and total impulsivity. These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control.

Authors+Show Affiliations

Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States. conklinsm@upmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17383013

Citation

Conklin, Sarah M., et al. "Serum Omega-3 Fatty Acids Are Associated With Variation in Mood, Personality and Behavior in Hypercholesterolemic Community Volunteers." Psychiatry Research, vol. 152, no. 1, 2007, pp. 1-10.
Conklin SM, Harris JI, Manuck SB, et al. Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. Psychiatry Res. 2007;152(1):1-10.
Conklin, S. M., Harris, J. I., Manuck, S. B., Yao, J. K., Hibbeln, J. R., & Muldoon, M. F. (2007). Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. Psychiatry Research, 152(1), 1-10.
Conklin SM, et al. Serum Omega-3 Fatty Acids Are Associated With Variation in Mood, Personality and Behavior in Hypercholesterolemic Community Volunteers. Psychiatry Res. 2007 Jul 30;152(1):1-10. PubMed PMID: 17383013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. AU - Conklin,Sarah M, AU - Harris,Jennifer I, AU - Manuck,Stephen B, AU - Yao,Jeffrey K, AU - Hibbeln,Joseph R, AU - Muldoon,Matthew F, Y1 - 2007/03/23/ PY - 2006/07/09/received PY - 2006/09/12/revised PY - 2006/10/01/accepted PY - 2007/3/27/pubmed PY - 2007/10/16/medline PY - 2007/3/27/entrez SP - 1 EP - 10 JF - Psychiatry research JO - Psychiatry Res VL - 152 IS - 1 N2 - Low dietary intake of omega-3 polyunsaturated fatty acids has been linked to several features of psychiatric symptomatology, including depression, disorders of impulse control, and hostility. Preliminary intervention trials of omega-3 fatty acid supplementation for clinical depression and other disorders have reported benefit. However, few studies have investigated the relationships between these fatty acids and normative variability in mood, behavior and personality. Participants were 105 hypercholesterolemic, but otherwise healthy, non-smoking adults. Fasting serum alpha-linolenic (alpha-LNA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) were assayed with gas chromatography. Participants completed the Beck Depression Inventory (BDI), the NEO Five Factor Personality Inventory (NEO-FFI) and the Barratt Impulsiveness Scale (BIS). In multivariate analyses, higher levels of the long chain omega-3 PUFAs, EPA and DHA, were associated with significantly reduced odds of scoring >or=10 on the BDI. Similarly, DHA and EPA covaried inversely with NEO-Neuroticism scores, whereas DHA was positively associated with NEO-Agreeableness. On the BIS, DHA was inversely related to cognitive impulsivity and alpha-LNA was inversely related to motor and total impulsivity. These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/17383013/Serum_omega_3_fatty_acids_are_associated_with_variation_in_mood_personality_and_behavior_in_hypercholesterolemic_community_volunteers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(06)00320-9 DB - PRIME DP - Unbound Medicine ER -