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Associations of polymorphism of P22(phox) C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China.
Am Heart J. 2007 Apr; 153(4):640.e1-6.AH

Abstract

BACKGROUND

The C242T polymorphisms of P22(phox) and plasma vitamin E have been associated with the risk of coronary heart disease (CHD) in several studies, but the results have been inconsistent. In this study, we sought to examine potential interactions between P22(phox) genotypes, plasma vitamin E concentrations, and smoking in relation to CHD risk.

METHODS

We determined C242T genotype frequency in the P22(phox) gene and plasma levels of vitamin E in 565 Chinese patients with CHD and 609 control subjects. Logistic regression was used to control for potential confounders in multivariate analyses.

RESULTS

Compared with subjects with a CC genotype, subjects with a CT or TT genotype had a lower risk of CHD (multivariate-adjusted odds ratio [OR] 0.45, 95% CI 0.28-0.74, P = .001). Plasma concentrations of vitamin E were lower in case patients than in control subjects (multivariate-adjusted OR 0.65, 95% CI 0.50-0.86, P = .025). Compared with nonsmokers with a CC genotype, nonsmokers with a CT or TT genotype had a decreased risk of CHD (OR 0.25, 95% CI 0.12-0.53), but smokers with a CT or TT genotype had an increased risk (OR 2.04, 95% CI 0.74-5.61, P for interaction = .039). Smokers with a lower vitamin E concentration had a >3.0-fold greater risk of CHD than did nonsmokers with a higher vitamin E concentration (OR 3.52, 95% CI 2.36-5.24, P for interaction = .041).

CONCLUSIONS

These data provide evidence that P22(phox) genotypes are significantly associated with CHD risk in a Chinese population and suggest potential interactions among smoking, P22(phox) genotypes, and vitamin E in relation to CHD risk.

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Authors+Show Affiliations

He MA
Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, Wuhan, Hubei, China.
Cheng LX
No affiliation info available
Jiang CZ
No affiliation info available
Zeng HS
No affiliation info available
Wang J
No affiliation info available
Wang F
No affiliation info available
Chen Y
No affiliation info available
Yang M
No affiliation info available
Tan H
No affiliation info available
Zheng HY
No affiliation info available
Hu FB
No affiliation info available
Wu TC
No affiliation info available

MeSH

Case-Control StudiesChinaCoronary DiseaseFemaleGenotypeHumansMaleMiddle AgedNADPH OxidasesPolymorphism, GeneticRisk FactorsSmokingVitamin E

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17383305

Citation

He, Mei-An, et al. "Associations of Polymorphism of P22(phox) C242T, Plasma Levels of Vitamin E, and Smoking With Coronary Heart Disease in China." American Heart Journal, vol. 153, no. 4, 2007, pp. 640.e1-6.
He MA, Cheng LX, Jiang CZ, et al. Associations of polymorphism of P22(phox) C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China. Am Heart J. 2007;153(4):640.e1-6.
He, M. A., Cheng, L. X., Jiang, C. Z., Zeng, H. S., Wang, J., Wang, F., Chen, Y., Yang, M., Tan, H., Zheng, H. Y., Hu, F. B., & Wu, T. C. (2007). Associations of polymorphism of P22(phox) C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China. American Heart Journal, 153(4), e1-6.
He MA, et al. Associations of Polymorphism of P22(phox) C242T, Plasma Levels of Vitamin E, and Smoking With Coronary Heart Disease in China. Am Heart J. 2007;153(4):640.e1-6. PubMed PMID: 17383305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of polymorphism of P22(phox) C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China. AU - He,Mei-An, AU - Cheng,Long-Xian, AU - Jiang,Chang-Zheng, AU - Zeng,He-Song, AU - Wang,Jing, AU - Wang,Feng, AU - Chen,Ying, AU - Yang,Miao, AU - Tan,Hao, AU - Zheng,Hong-Yan, AU - Hu,Frank B, AU - Wu,Tang-Chun, PY - 2006/09/06/received PY - 2007/01/05/accepted PY - 2007/3/27/pubmed PY - 2007/5/4/medline PY - 2007/3/27/entrez SP - 640.e1 EP - 6 JF - American heart journal JO - Am Heart J VL - 153 IS - 4 N2 - BACKGROUND: The C242T polymorphisms of P22(phox) and plasma vitamin E have been associated with the risk of coronary heart disease (CHD) in several studies, but the results have been inconsistent. In this study, we sought to examine potential interactions between P22(phox) genotypes, plasma vitamin E concentrations, and smoking in relation to CHD risk. METHODS: We determined C242T genotype frequency in the P22(phox) gene and plasma levels of vitamin E in 565 Chinese patients with CHD and 609 control subjects. Logistic regression was used to control for potential confounders in multivariate analyses. RESULTS: Compared with subjects with a CC genotype, subjects with a CT or TT genotype had a lower risk of CHD (multivariate-adjusted odds ratio [OR] 0.45, 95% CI 0.28-0.74, P = .001). Plasma concentrations of vitamin E were lower in case patients than in control subjects (multivariate-adjusted OR 0.65, 95% CI 0.50-0.86, P = .025). Compared with nonsmokers with a CC genotype, nonsmokers with a CT or TT genotype had a decreased risk of CHD (OR 0.25, 95% CI 0.12-0.53), but smokers with a CT or TT genotype had an increased risk (OR 2.04, 95% CI 0.74-5.61, P for interaction = .039). Smokers with a lower vitamin E concentration had a >3.0-fold greater risk of CHD than did nonsmokers with a higher vitamin E concentration (OR 3.52, 95% CI 2.36-5.24, P for interaction = .041). CONCLUSIONS: These data provide evidence that P22(phox) genotypes are significantly associated with CHD risk in a Chinese population and suggest potential interactions among smoking, P22(phox) genotypes, and vitamin E in relation to CHD risk. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/17383305/Associations_of_polymorphism_of_P22_phox__C242T_plasma_levels_of_vitamin_E_and_smoking_with_coronary_heart_disease_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(07)00052-X DB - PRIME DP - Unbound Medicine ER -