Tags

Type your tag names separated by a space and hit enter

Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer.
Ann Thorac Surg. 2007 Apr; 83(4):1245-9; discussion 1250.AT

Abstract

BACKGROUND

We conducted a study of patients who underwent anatomic resection with adjuvant chemotherapy to determine if thoracoscopic lobectomy enables more effective administration of adjuvant chemotherapy than lobectomy by thoracotomy.

METHODS

We reviewed the outcomes of 100 consecutive patients with non-small cell lung cancer (NSCLC) who underwent lobectomy and received adjuvant chemotherapy (1999 to 2004). The variables analyzed were time to initiation of chemotherapy, percentage of planned regimen received, number of delayed or reduced chemotherapy doses, toxicity grade, length of hospitalization, chest tube duration, 30-day mortality, and major complications (pneumonia, respiratory failure, atrial fibrillation). The chi2 test and Student t test were used to compare dichotomous and continuous variables, respectively.

RESULTS

Complete resection was performed by thoracotomy in 43 patients and by thoracoscopy in 57 (no conversions). All patients received adjuvant chemotherapy, and 20 (20%) received adjuvant radiation therapy: 13 (30%) of 43 in the thoracotomy group and 7 (12%) of 57 in the thoracoscopy group (p = 0.04). Patients undergoing thoracoscopic lobectomy had significantly fewer delayed (18% versus 58%, p < 0.001) and reduced (26% versus 49%, p = 0.02) chemotherapy doses. A higher percentage of patients undergoing thoracoscopic resection received 75% or more of their planned adjuvant regimen without delayed or reduced doses (61% versus 40%, p = 0.03). There were no significant differences in time to initiation of chemotherapy or toxicity. Patients undergoing a thoracoscopic lobectomy had a shorter median length of hospitalization (4 days versus 5 days, p = 0.02).

CONCLUSIONS

Thoracoscopy was associated with an overall higher compliance rate and fewer delayed or reduced doses of chemotherapy in patients receiving adjuvant chemotherapy.

Authors+Show Affiliations

Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17383320

Citation

Petersen, Rebecca P., et al. "Thoracoscopic Lobectomy Facilitates the Delivery of Chemotherapy After Resection for Lung Cancer." The Annals of Thoracic Surgery, vol. 83, no. 4, 2007, pp. 1245-9; discussion 1250.
Petersen RP, Pham D, Burfeind WR, et al. Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. Ann Thorac Surg. 2007;83(4):1245-9; discussion 1250.
Petersen, R. P., Pham, D., Burfeind, W. R., Hanish, S. I., Toloza, E. M., Harpole, D. H., & D'Amico, T. A. (2007). Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. The Annals of Thoracic Surgery, 83(4), 1245-9; discussion 1250.
Petersen RP, et al. Thoracoscopic Lobectomy Facilitates the Delivery of Chemotherapy After Resection for Lung Cancer. Ann Thorac Surg. 2007;83(4):1245-9; discussion 1250. PubMed PMID: 17383320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. AU - Petersen,Rebecca P, AU - Pham,DuyKhanh, AU - Burfeind,William R, AU - Hanish,Steven I, AU - Toloza,Eric M, AU - Harpole,David H,Jr AU - D'Amico,Thomas A, PY - 2006/11/09/received PY - 2006/12/13/revised PY - 2006/12/18/accepted PY - 2007/3/27/pubmed PY - 2007/4/14/medline PY - 2007/3/27/entrez SP - 1245-9; discussion 1250 JF - The Annals of thoracic surgery JO - Ann Thorac Surg VL - 83 IS - 4 N2 - BACKGROUND: We conducted a study of patients who underwent anatomic resection with adjuvant chemotherapy to determine if thoracoscopic lobectomy enables more effective administration of adjuvant chemotherapy than lobectomy by thoracotomy. METHODS: We reviewed the outcomes of 100 consecutive patients with non-small cell lung cancer (NSCLC) who underwent lobectomy and received adjuvant chemotherapy (1999 to 2004). The variables analyzed were time to initiation of chemotherapy, percentage of planned regimen received, number of delayed or reduced chemotherapy doses, toxicity grade, length of hospitalization, chest tube duration, 30-day mortality, and major complications (pneumonia, respiratory failure, atrial fibrillation). The chi2 test and Student t test were used to compare dichotomous and continuous variables, respectively. RESULTS: Complete resection was performed by thoracotomy in 43 patients and by thoracoscopy in 57 (no conversions). All patients received adjuvant chemotherapy, and 20 (20%) received adjuvant radiation therapy: 13 (30%) of 43 in the thoracotomy group and 7 (12%) of 57 in the thoracoscopy group (p = 0.04). Patients undergoing thoracoscopic lobectomy had significantly fewer delayed (18% versus 58%, p < 0.001) and reduced (26% versus 49%, p = 0.02) chemotherapy doses. A higher percentage of patients undergoing thoracoscopic resection received 75% or more of their planned adjuvant regimen without delayed or reduced doses (61% versus 40%, p = 0.03). There were no significant differences in time to initiation of chemotherapy or toxicity. Patients undergoing a thoracoscopic lobectomy had a shorter median length of hospitalization (4 days versus 5 days, p = 0.02). CONCLUSIONS: Thoracoscopy was associated with an overall higher compliance rate and fewer delayed or reduced doses of chemotherapy in patients receiving adjuvant chemotherapy. SN - 1552-6259 UR - https://www.unboundmedicine.com/medline/citation/17383320/Thoracoscopic_lobectomy_facilitates_the_delivery_of_chemotherapy_after_resection_for_lung_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-4975(06)02544-6 DB - PRIME DP - Unbound Medicine ER -