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Cannabis abuse and risk for psychosis in a prodromal sample.
Psychiatry Res 2007; 151(1-2):151-4PR

Abstract

The goal of the present study was to examine the rate of cannabis use among participants in the Cognitive Assessment and Risk Evaluation (CARE) Program, a longitudinal program for individuals who are "at risk" for developing a psychotic disorder. Cannabis abuse was assessed in 48 individuals identified as at risk for psychosis based on subsyndromal psychotic symptoms and/or family history. At 1 year follow-up, 6 of the 48 (12.5%) at risk subjects had made the transition to psychosis. Of the 32 subjects who had no use or minimal cannabis use, one subject (3.1%) converted to psychosis. Of the 16 subjects who met criteria for cannabis abuse/dependence, five (31.3%) converted to psychosis. The results show a significant association between cannabis abuse and conversion to psychosis in this sample. Nicotine use was also found to be significantly associated with later conversion. The significant associations between cannabis and nicotine abuse and conversion to psychosis in individuals at risk for schizophrenia suggest that early identification and intervention programs should screen for and provide education about the deleterious effects of these substances.

Authors+Show Affiliations

Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0810, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17383738

Citation

Kristensen, Karin, and Kristin S. Cadenhead. "Cannabis Abuse and Risk for Psychosis in a Prodromal Sample." Psychiatry Research, vol. 151, no. 1-2, 2007, pp. 151-4.
Kristensen K, Cadenhead KS. Cannabis abuse and risk for psychosis in a prodromal sample. Psychiatry Res. 2007;151(1-2):151-4.
Kristensen, K., & Cadenhead, K. S. (2007). Cannabis abuse and risk for psychosis in a prodromal sample. Psychiatry Research, 151(1-2), pp. 151-4.
Kristensen K, Cadenhead KS. Cannabis Abuse and Risk for Psychosis in a Prodromal Sample. Psychiatry Res. 2007 May 30;151(1-2):151-4. PubMed PMID: 17383738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis abuse and risk for psychosis in a prodromal sample. AU - Kristensen,Karin, AU - Cadenhead,Kristin S, Y1 - 2007/03/26/ PY - 2005/07/01/received PY - 2006/09/13/revised PY - 2006/10/02/accepted PY - 2007/3/27/pubmed PY - 2007/8/10/medline PY - 2007/3/27/entrez SP - 151 EP - 4 JF - Psychiatry research JO - Psychiatry Res VL - 151 IS - 1-2 N2 - The goal of the present study was to examine the rate of cannabis use among participants in the Cognitive Assessment and Risk Evaluation (CARE) Program, a longitudinal program for individuals who are "at risk" for developing a psychotic disorder. Cannabis abuse was assessed in 48 individuals identified as at risk for psychosis based on subsyndromal psychotic symptoms and/or family history. At 1 year follow-up, 6 of the 48 (12.5%) at risk subjects had made the transition to psychosis. Of the 32 subjects who had no use or minimal cannabis use, one subject (3.1%) converted to psychosis. Of the 16 subjects who met criteria for cannabis abuse/dependence, five (31.3%) converted to psychosis. The results show a significant association between cannabis abuse and conversion to psychosis in this sample. Nicotine use was also found to be significantly associated with later conversion. The significant associations between cannabis and nicotine abuse and conversion to psychosis in individuals at risk for schizophrenia suggest that early identification and intervention programs should screen for and provide education about the deleterious effects of these substances. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/17383738/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(06)00315-5 DB - PRIME DP - Unbound Medicine ER -