Tags

Type your tag names separated by a space and hit enter

Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia.
Neurosci Lett. 2007 May 07; 417(3):271-4.NL

Abstract

Neurocognitive deficits are recognized as core features of schizophrenia and have a great impact on functional outcome. Recent reports have suggested that a functional polymorphism, Val158Met, of the catechol-O-methyltransferase (COMT) gene, partially influences cognitive performances (mainly cognitive flexibility and working memory) both in schizophrenic patients and in healthy controls, probably by modulating prefrontal dopamine function. While previous studies focused on single evaluation of cognitive functioning, we aimed to analyse the additive effect of COMT genotype and cognitive exercise on dynamic modulation of cognitive performances. We analysed the COMT Val158Met polymorphism in 50 patients with chronic schizophrenia randomly allocated to two treatment conditions for 3 months: standard rehabilitation treatment (SRT) alone and SRT plus specific cognitive exercise of impaired functions. We then divided our sample in four subgroups on the basis of genotype (Val/Val versus Met carriers) and treatment (placebo versus active). We assessed patients with a neuropsychological battery, the Positive and Negative Symptoms Scale (PANSS) and the Quality of Life Scale (QLS) at enrolment, after 3 months of therapy and after further 3 months of follow-up. We found significantly greater improvement of cognitive flexibility performance and QLS total score for Met carriers on active treatment in comparison to Val/Val on placebo. The findings support the hypothesis that COMT polymorphism influences individual capacity to recover from cognitive deficit through rehabilitation therapy after a wider intervention also including deficit-specific cognitive exercise as a potentiating tool.

Authors+Show Affiliations

Department of Neuropsychiatric Sciences, San Raffaele Universitary Scientific Institute Hospital, Vita-Salute San Raffaele University, Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17383818

Citation

Bosia, Marta, et al. "Influence of catechol-O-methyltransferase Val158Met Polymorphism On Neuropsychological and Functional Outcomes of Classical Rehabilitation and Cognitive Remediation in Schizophrenia." Neuroscience Letters, vol. 417, no. 3, 2007, pp. 271-4.
Bosia M, Bechi M, Marino E, et al. Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia. Neurosci Lett. 2007;417(3):271-4.
Bosia, M., Bechi, M., Marino, E., Anselmetti, S., Poletti, S., Cocchi, F., Smeraldi, E., & Cavallaro, R. (2007). Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia. Neuroscience Letters, 417(3), 271-4.
Bosia M, et al. Influence of catechol-O-methyltransferase Val158Met Polymorphism On Neuropsychological and Functional Outcomes of Classical Rehabilitation and Cognitive Remediation in Schizophrenia. Neurosci Lett. 2007 May 7;417(3):271-4. PubMed PMID: 17383818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia. AU - Bosia,Marta, AU - Bechi,Margherita, AU - Marino,Elena, AU - Anselmetti,Simona, AU - Poletti,Sara, AU - Cocchi,Federica, AU - Smeraldi,Enrico, AU - Cavallaro,Roberto, Y1 - 2007/03/02/ PY - 2006/09/19/received PY - 2007/02/14/revised PY - 2007/02/16/accepted PY - 2007/3/27/pubmed PY - 2007/7/26/medline PY - 2007/3/27/entrez SP - 271 EP - 4 JF - Neuroscience letters JO - Neurosci. Lett. VL - 417 IS - 3 N2 - Neurocognitive deficits are recognized as core features of schizophrenia and have a great impact on functional outcome. Recent reports have suggested that a functional polymorphism, Val158Met, of the catechol-O-methyltransferase (COMT) gene, partially influences cognitive performances (mainly cognitive flexibility and working memory) both in schizophrenic patients and in healthy controls, probably by modulating prefrontal dopamine function. While previous studies focused on single evaluation of cognitive functioning, we aimed to analyse the additive effect of COMT genotype and cognitive exercise on dynamic modulation of cognitive performances. We analysed the COMT Val158Met polymorphism in 50 patients with chronic schizophrenia randomly allocated to two treatment conditions for 3 months: standard rehabilitation treatment (SRT) alone and SRT plus specific cognitive exercise of impaired functions. We then divided our sample in four subgroups on the basis of genotype (Val/Val versus Met carriers) and treatment (placebo versus active). We assessed patients with a neuropsychological battery, the Positive and Negative Symptoms Scale (PANSS) and the Quality of Life Scale (QLS) at enrolment, after 3 months of therapy and after further 3 months of follow-up. We found significantly greater improvement of cognitive flexibility performance and QLS total score for Met carriers on active treatment in comparison to Val/Val on placebo. The findings support the hypothesis that COMT polymorphism influences individual capacity to recover from cognitive deficit through rehabilitation therapy after a wider intervention also including deficit-specific cognitive exercise as a potentiating tool. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17383818/Influence_of_catechol_O_methyltransferase_Val158Met_polymorphism_on_neuropsychological_and_functional_outcomes_of_classical_rehabilitation_and_cognitive_remediation_in_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)00231-5 DB - PRIME DP - Unbound Medicine ER -