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Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study.
Am J Geriatr Psychiatry. 2007 Apr; 15(4):335-43.AJ

Abstract

OBJECTIVE

Depression has been linked with vascular risk factors and stroke. The authors examined the relationship between retinal microvascular abnormalities and depression symptoms in an elderly population.

METHODS

The Cardiovascular Health Study is a population-based study conducted in four U.S. communities initiated in 1989-1990. A total of 2,420 persons aged 65 years and older were included in the current analyses. During the 1997-1998 examination, retinal photographs were performed and assessed for retinal microvascular abnormalities (retinopathy, focal arteriolar narrowing, arteriovenous nicking, generalized retinal arteriolar narrowing, and generalized retinal venular dilation) according to standardized methods. Depression symptoms were assessed by a modified version of the Centers for Epidemiologic Studies Depression (CES-D) scale annually from 1989 through 1997-1998 and was defined as a CES-D score of >9.

RESULTS

Participants with retinal microvascular abnormalities were not more likely to have depression symptoms, with adjusted odds ratio (OR) (95% confidence intervals) of 1.08 (0.71-1.65) for retinopathy, OR 1.09 (0.71-1.68) for focal arteriolar narrowing, OR 0.85 (0.52-1.40) for arteriovenous nicking, OR 0.97 (0.70-1.34) for generalized arteriolar narrowing, and OR 0.79 (0.56-1.12) for generalized venular dilation. Retinal microvascular abnormalities were not related to depression symptoms in multinomial logistic regression comparing the three top quartiles of the depression CES-D scores with the lowest quartile.

CONCLUSIONS

Our study did not find an association between retinal microvascular abnormalities and depression symptoms in older people.

Authors+Show Affiliations

Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17384316

Citation

Sun, Cong, et al. "Are Microvascular Abnormalities in the Retina Associated With Depression Symptoms? the Cardiovascular Health Study." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 15, no. 4, 2007, pp. 335-43.
Sun C, Tikellis G, Klein R, et al. Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study. Am J Geriatr Psychiatry. 2007;15(4):335-43.
Sun, C., Tikellis, G., Klein, R., Steffens, D. C., Larsen, E. K., Siscovick, D. S., Klein, B. E., & Wong, T. Y. (2007). Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 15(4), 335-43.
Sun C, et al. Are Microvascular Abnormalities in the Retina Associated With Depression Symptoms? the Cardiovascular Health Study. Am J Geriatr Psychiatry. 2007;15(4):335-43. PubMed PMID: 17384316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study. AU - Sun,Cong, AU - Tikellis,Gabriella, AU - Klein,Ronald, AU - Steffens,David C, AU - Larsen,Emily K Marino, AU - Siscovick,David S, AU - Klein,Barbara E K, AU - Wong,Tien Y, PY - 2007/3/27/pubmed PY - 2007/7/17/medline PY - 2007/3/27/entrez SP - 335 EP - 43 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 15 IS - 4 N2 - OBJECTIVE: Depression has been linked with vascular risk factors and stroke. The authors examined the relationship between retinal microvascular abnormalities and depression symptoms in an elderly population. METHODS: The Cardiovascular Health Study is a population-based study conducted in four U.S. communities initiated in 1989-1990. A total of 2,420 persons aged 65 years and older were included in the current analyses. During the 1997-1998 examination, retinal photographs were performed and assessed for retinal microvascular abnormalities (retinopathy, focal arteriolar narrowing, arteriovenous nicking, generalized retinal arteriolar narrowing, and generalized retinal venular dilation) according to standardized methods. Depression symptoms were assessed by a modified version of the Centers for Epidemiologic Studies Depression (CES-D) scale annually from 1989 through 1997-1998 and was defined as a CES-D score of >9. RESULTS: Participants with retinal microvascular abnormalities were not more likely to have depression symptoms, with adjusted odds ratio (OR) (95% confidence intervals) of 1.08 (0.71-1.65) for retinopathy, OR 1.09 (0.71-1.68) for focal arteriolar narrowing, OR 0.85 (0.52-1.40) for arteriovenous nicking, OR 0.97 (0.70-1.34) for generalized arteriolar narrowing, and OR 0.79 (0.56-1.12) for generalized venular dilation. Retinal microvascular abnormalities were not related to depression symptoms in multinomial logistic regression comparing the three top quartiles of the depression CES-D scores with the lowest quartile. CONCLUSIONS: Our study did not find an association between retinal microvascular abnormalities and depression symptoms in older people. SN - 1064-7481 UR - https://www.unboundmedicine.com/medline/citation/17384316/Are_microvascular_abnormalities_in_the_retina_associated_with_depression_symptoms_The_Cardiovascular_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/15/4/335 DB - PRIME DP - Unbound Medicine ER -