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Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.
Diabetes Care. 2007 Jun; 30(6):1501-6.DC

Abstract

OBJECTIVE

Resistin, secreted from adipocytes, causes insulin resistance in rodents. We previously reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes susceptibility by enhancing promoter activity. We report here on the relation between plasma resistin and either SNP -420 genotype or factors related to insulin resistance.

RESEARCH DESIGN AND METHODS

We cross-sectionally analyzed 2,078 community-dwelling Japanese subjects attending a yearly medical checkup. The SNP -420 genotype was determined by TaqMan analysis. Fasting plasma resistin was measured using an enzyme-linked immunosorbent assay kit.

RESULTS

Plasma resistin was associated with the SNP -420 genotype (P < 0.0001), which was highest in G/G followed by C/G and C/C. Plasma resistin was higher in elderly individuals, female subjects, nondrinkers, and subjects with high blood pressure (P < 0.001, 0.003, <0.001, and 0.001, respectively). Simple regression analysis revealed that age, female sex, homeostasis model assessment of insulin resistance (HOMA-IR) index, systolic blood pressure, low HDL cholesterol, and high-sensitivity C-reactive protein (hs-CRP) were positively correlated with plasma resistin (P < 0.001, 0.003, <0.001, 0.004, <0.001, and 0.003, respectively). Multiple regression analysis adjusted for age, sex, and BMI revealed that plasma resistin was an independent factor for HOMA-IR, low HDL cholesterol, and hs-CRP (P = 0.001, <0.001, and 0.006, respectively).

CONCLUSIONS

Plasma resistin was associated with SNP -420 and was correlated with insulin resistance, low serum HDL cholesterol, and high hs-CRP in the Japanese general population.

Authors+Show Affiliations

Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan. harosawa@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17384338

Citation

Osawa, Haruhiko, et al. "Plasma Resistin, Associated With Single Nucleotide Polymorphism -420, Is Correlated With Insulin Resistance, Lower HDL Cholesterol, and High-sensitivity C-reactive Protein in the Japanese General Population." Diabetes Care, vol. 30, no. 6, 2007, pp. 1501-6.
Osawa H, Tabara Y, Kawamoto R, et al. Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care. 2007;30(6):1501-6.
Osawa, H., Tabara, Y., Kawamoto, R., Ohashi, J., Ochi, M., Onuma, H., Nishida, W., Yamada, K., Nakura, J., Kohara, K., Miki, T., & Makino, H. (2007). Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care, 30(6), 1501-6.
Osawa H, et al. Plasma Resistin, Associated With Single Nucleotide Polymorphism -420, Is Correlated With Insulin Resistance, Lower HDL Cholesterol, and High-sensitivity C-reactive Protein in the Japanese General Population. Diabetes Care. 2007;30(6):1501-6. PubMed PMID: 17384338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. AU - Osawa,Haruhiko, AU - Tabara,Yasuharu, AU - Kawamoto,Ryuichi, AU - Ohashi,Jun, AU - Ochi,Masaaki, AU - Onuma,Hiroshi, AU - Nishida,Wataru, AU - Yamada,Kazuya, AU - Nakura,Jun, AU - Kohara,Katsuhiko, AU - Miki,Tetsuro, AU - Makino,Hideichi, Y1 - 2007/03/23/ PY - 2007/3/27/pubmed PY - 2007/6/15/medline PY - 2007/3/27/entrez SP - 1501 EP - 6 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 6 N2 - OBJECTIVE: Resistin, secreted from adipocytes, causes insulin resistance in rodents. We previously reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes susceptibility by enhancing promoter activity. We report here on the relation between plasma resistin and either SNP -420 genotype or factors related to insulin resistance. RESEARCH DESIGN AND METHODS: We cross-sectionally analyzed 2,078 community-dwelling Japanese subjects attending a yearly medical checkup. The SNP -420 genotype was determined by TaqMan analysis. Fasting plasma resistin was measured using an enzyme-linked immunosorbent assay kit. RESULTS: Plasma resistin was associated with the SNP -420 genotype (P < 0.0001), which was highest in G/G followed by C/G and C/C. Plasma resistin was higher in elderly individuals, female subjects, nondrinkers, and subjects with high blood pressure (P < 0.001, 0.003, <0.001, and 0.001, respectively). Simple regression analysis revealed that age, female sex, homeostasis model assessment of insulin resistance (HOMA-IR) index, systolic blood pressure, low HDL cholesterol, and high-sensitivity C-reactive protein (hs-CRP) were positively correlated with plasma resistin (P < 0.001, 0.003, <0.001, 0.004, <0.001, and 0.003, respectively). Multiple regression analysis adjusted for age, sex, and BMI revealed that plasma resistin was an independent factor for HOMA-IR, low HDL cholesterol, and hs-CRP (P = 0.001, <0.001, and 0.006, respectively). CONCLUSIONS: Plasma resistin was associated with SNP -420 and was correlated with insulin resistance, low serum HDL cholesterol, and high hs-CRP in the Japanese general population. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17384338/Plasma_resistin_associated_with_single_nucleotide_polymorphism__420_is_correlated_with_insulin_resistance_lower_HDL_cholesterol_and_high_sensitivity_C_reactive_protein_in_the_Japanese_general_population_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17384338 DB - PRIME DP - Unbound Medicine ER -