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Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects.
Diabetes Care. 2007 Jul; 30(7):1717-23.DC

Abstract

OBJECTIVE

Central obesity is associated with insulin resistance through factors that are not fully understood. We studied the effects of three different isocaloric diets on body fat distribution, insulin sensitivity, and peripheral adiponectin gene expression.

RESEARCH DESIGN AND METHODS

Eleven volunteers, offspring of obese type 2 diabetic patients with abdominal fat deposition, were studied. These subjects were considered insulin resistant as indicated by Matsuda index values <4 after an oral glucose tolerance test, and they maintained A1C <6.5% without therapeutic intervention. All subjects underwent three dietary periods of 28 days each in a crossover design: 1) diet enriched in saturated fat (SAT), 2) diet rich in monounsaturated fat (MUFA) (Mediterranean diet), and 3) diet rich in carbohydrates (CHOs).

RESULTS

Weight, body composition, and resting energy expenditure remained unchanged during the three sequential dietary periods. Using dual-energy X-ray absorptiometry we observed that when patients were fed a CHO-enriched diet, their fat mass was redistributed toward the abdominal depot, whereas periphery fat accumulation decreased compared with isocaloric MUFA-rich and high-SAT diets (ANOVA P < 0.05). Changes in fat deposition were associated with decreased postprandial mRNA adiponectin levels in peripheral adipose tissue and lower insulin sensitivity index values from a frequently sampled insulin-assisted intravenous glucose tolerance test in patients fed a CHO-rich diet compared with a MUFA-rich diet (ANOVA P < 0.05).

CONCLUSIONS

An isocaloric MUFA-rich diet prevents central fat redistribution and the postprandial decrease in peripheral adiponectin gene expression and insulin resistance induced by a CHO-rich diet in insulin-resistant subjects.

Authors+Show Affiliations

Lipids and Atherosclerosis Research Unit, Reina Sofía University Hospital, Córdoba, Spain. japaniaguag@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17384344

Citation

Paniagua, J A., et al. "Monounsaturated Fat-rich Diet Prevents Central Body Fat Distribution and Decreases Postprandial Adiponectin Expression Induced By a Carbohydrate-rich Diet in Insulin-resistant Subjects." Diabetes Care, vol. 30, no. 7, 2007, pp. 1717-23.
Paniagua JA, Gallego de la Sacristana A, Romero I, et al. Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects. Diabetes Care. 2007;30(7):1717-23.
Paniagua, J. A., Gallego de la Sacristana, A., Romero, I., Vidal-Puig, A., Latre, J. M., Sanchez, E., Perez-Martinez, P., Lopez-Miranda, J., & Perez-Jimenez, F. (2007). Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects. Diabetes Care, 30(7), 1717-23.
Paniagua JA, et al. Monounsaturated Fat-rich Diet Prevents Central Body Fat Distribution and Decreases Postprandial Adiponectin Expression Induced By a Carbohydrate-rich Diet in Insulin-resistant Subjects. Diabetes Care. 2007;30(7):1717-23. PubMed PMID: 17384344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects. AU - Paniagua,J A, AU - Gallego de la Sacristana,A, AU - Romero,I, AU - Vidal-Puig,A, AU - Latre,J M, AU - Sanchez,E, AU - Perez-Martinez,P, AU - Lopez-Miranda,J, AU - Perez-Jimenez,F, Y1 - 2007/03/23/ PY - 2007/3/27/pubmed PY - 2007/7/13/medline PY - 2007/3/27/entrez SP - 1717 EP - 23 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 7 N2 - OBJECTIVE: Central obesity is associated with insulin resistance through factors that are not fully understood. We studied the effects of three different isocaloric diets on body fat distribution, insulin sensitivity, and peripheral adiponectin gene expression. RESEARCH DESIGN AND METHODS: Eleven volunteers, offspring of obese type 2 diabetic patients with abdominal fat deposition, were studied. These subjects were considered insulin resistant as indicated by Matsuda index values <4 after an oral glucose tolerance test, and they maintained A1C <6.5% without therapeutic intervention. All subjects underwent three dietary periods of 28 days each in a crossover design: 1) diet enriched in saturated fat (SAT), 2) diet rich in monounsaturated fat (MUFA) (Mediterranean diet), and 3) diet rich in carbohydrates (CHOs). RESULTS: Weight, body composition, and resting energy expenditure remained unchanged during the three sequential dietary periods. Using dual-energy X-ray absorptiometry we observed that when patients were fed a CHO-enriched diet, their fat mass was redistributed toward the abdominal depot, whereas periphery fat accumulation decreased compared with isocaloric MUFA-rich and high-SAT diets (ANOVA P < 0.05). Changes in fat deposition were associated with decreased postprandial mRNA adiponectin levels in peripheral adipose tissue and lower insulin sensitivity index values from a frequently sampled insulin-assisted intravenous glucose tolerance test in patients fed a CHO-rich diet compared with a MUFA-rich diet (ANOVA P < 0.05). CONCLUSIONS: An isocaloric MUFA-rich diet prevents central fat redistribution and the postprandial decrease in peripheral adiponectin gene expression and insulin resistance induced by a CHO-rich diet in insulin-resistant subjects. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17384344/Monounsaturated_fat_rich_diet_prevents_central_body_fat_distribution_and_decreases_postprandial_adiponectin_expression_induced_by_a_carbohydrate_rich_diet_in_insulin_resistant_subjects_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17384344 DB - PRIME DP - Unbound Medicine ER -