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Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study.

Abstract

INTRODUCTION

Alcohol abuse, alcohol intolerance and other alcohol-related disabilities are some of the most challenging public health problems. Alcohol, by its property of generating free radicals, causes severe damage to the membrane and affects almost all organs of the human body. Ellagic acid (EA), a natural polyphenolic compound found in fruits and nuts, possess several biological properties. Our aim was to investigate, in vivo, the antioxidant potential of ellagic acid against oxidative stress induced by alcohol intoxication.

METHODS

Female albino Wistar rats were used for the study. The toxicity was induced by administering 20 percent alcohol orally (7.9 g/kg body weight) for 45 days. Rats were treated with EA at three different doses (30, 60 and 90 mg/kg body weight) via intragastric intubations. The antioxidant property of EA was studied by assessing the activities of liver marker enzymes (gamma-glutamyl transferase and alkaline phosphatase), superoxide dismutase and catalase and the levels of vitamin E, vitamin C and reduced glutathione, nitric oxide (NO), protein carbonyl content (PCC), thiobarbituric acid reactive substances (TBARS) and hydroperoxides.

RESULTS

Oxidative stress was effectively modulated by EA co-administration. EA significantly improved the status of antioxidants and decreased TBARS, hydroperoxides, NO, PCC and liver marker enzymes at the dose of 60 mg/kg body weight when compared with the alcohol-treated group.

CONCLUSION

The study provides the antioxidant and cytoprotective properties of EA at a dose of 60 mg/kg body weight against oxidative stress induced by alcohol.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.

    , ,

    Source

    Singapore medical journal 48:4 2007 Apr pg 311-8

    MeSH

    Alkaline Phosphatase
    Analysis of Variance
    Animals
    Antioxidants
    Biomarkers
    Dose-Response Relationship, Drug
    Ellagic Acid
    Ethanol
    Female
    Lipid Peroxides
    Nitric Oxide
    Oxidative Stress
    Rats
    Rats, Wistar
    Thiobarbituric Acid Reactive Substances
    gamma-Glutamyltransferase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17384878

    Citation

    Devipriya, N, et al. "Effect of Ellagic Acid, a Natural Polyphenol, On Alcohol-induced Prooxidant and Antioxidant Imbalance: a Drug Dose Dependent Study." Singapore Medical Journal, vol. 48, no. 4, 2007, pp. 311-8.
    Devipriya N, Srinivasan M, Sudheer AR, et al. Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study. Singapore Med J. 2007;48(4):311-8.
    Devipriya, N., Srinivasan, M., Sudheer, A. R., & Menon, V. P. (2007). Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study. Singapore Medical Journal, 48(4), pp. 311-8.
    Devipriya N, et al. Effect of Ellagic Acid, a Natural Polyphenol, On Alcohol-induced Prooxidant and Antioxidant Imbalance: a Drug Dose Dependent Study. Singapore Med J. 2007;48(4):311-8. PubMed PMID: 17384878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study. AU - Devipriya,N, AU - Srinivasan,M, AU - Sudheer,A R, AU - Menon,V P, PY - 2007/3/27/pubmed PY - 2007/5/4/medline PY - 2007/3/27/entrez SP - 311 EP - 8 JF - Singapore medical journal JO - Singapore Med J VL - 48 IS - 4 N2 - INTRODUCTION: Alcohol abuse, alcohol intolerance and other alcohol-related disabilities are some of the most challenging public health problems. Alcohol, by its property of generating free radicals, causes severe damage to the membrane and affects almost all organs of the human body. Ellagic acid (EA), a natural polyphenolic compound found in fruits and nuts, possess several biological properties. Our aim was to investigate, in vivo, the antioxidant potential of ellagic acid against oxidative stress induced by alcohol intoxication. METHODS: Female albino Wistar rats were used for the study. The toxicity was induced by administering 20 percent alcohol orally (7.9 g/kg body weight) for 45 days. Rats were treated with EA at three different doses (30, 60 and 90 mg/kg body weight) via intragastric intubations. The antioxidant property of EA was studied by assessing the activities of liver marker enzymes (gamma-glutamyl transferase and alkaline phosphatase), superoxide dismutase and catalase and the levels of vitamin E, vitamin C and reduced glutathione, nitric oxide (NO), protein carbonyl content (PCC), thiobarbituric acid reactive substances (TBARS) and hydroperoxides. RESULTS: Oxidative stress was effectively modulated by EA co-administration. EA significantly improved the status of antioxidants and decreased TBARS, hydroperoxides, NO, PCC and liver marker enzymes at the dose of 60 mg/kg body weight when compared with the alcohol-treated group. CONCLUSION: The study provides the antioxidant and cytoprotective properties of EA at a dose of 60 mg/kg body weight against oxidative stress induced by alcohol. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/17384878/Effect_of_ellagic_acid_a_natural_polyphenol_on_alcohol_induced_prooxidant_and_antioxidant_imbalance:_a_drug_dose_dependent_study_ L2 - http://smj.sma.org.sg/4804/4804a7.pdf DB - PRIME DP - Unbound Medicine ER -