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Statin use and the long-term risk of incident cataract: the Blue Mountains Eye Study.
Am J Ophthalmol. 2007 Apr; 143(4):687-9.AJ

Abstract

PURPOSE

To assess the association between statin use and long-term incident cataract.

DESIGN

Population-based cohort study.

METHODS

Of 3,654 baseline (1992 to 1994) elderly participants in the Blue Mountains Eye Study (BMES), 2,335 (75% of survivors) were reexamined after five years (1997 to 1999) and 1,952 (76% of survivors) after 10 years (2002 to 2004). Lens photographs were taken and graded using the Wisconsin Cataract Grading System. History, physical examination, and fasting blood samples provided data on possible risk factors. Discrete linear logistic models were used to assess the risk of cataract.

RESULTS

After controlling for age, gender, and other factors, statin use was protective for any cataract (hazard ratio [HR] 0.52; 95% confidence interval [CI] 0.29-0.93), but was not significantly associated with incident nuclear (HR 0.66; CI 0.35 to 1.25), cortical (HR 0.76; CI 0.44 to 1.33), or posterior subcapsular (PSC) cataract (HR 1.47; CI 0.70 to 3.08).

CONCLUSIONS

Statin use was found to reduce by 50% the risk of cataract development, principally nuclear or cortical cataract subtypes.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17386279

Citation

Tan, Jennifer S L., et al. "Statin Use and the Long-term Risk of Incident Cataract: the Blue Mountains Eye Study." American Journal of Ophthalmology, vol. 143, no. 4, 2007, pp. 687-9.
Tan JS, Mitchell P, Rochtchina E, et al. Statin use and the long-term risk of incident cataract: the Blue Mountains Eye Study. Am J Ophthalmol. 2007;143(4):687-9.
Tan, J. S., Mitchell, P., Rochtchina, E., & Wang, J. J. (2007). Statin use and the long-term risk of incident cataract: the Blue Mountains Eye Study. American Journal of Ophthalmology, 143(4), 687-9.
Tan JS, et al. Statin Use and the Long-term Risk of Incident Cataract: the Blue Mountains Eye Study. Am J Ophthalmol. 2007;143(4):687-9. PubMed PMID: 17386279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin use and the long-term risk of incident cataract: the Blue Mountains Eye Study. AU - Tan,Jennifer S L, AU - Mitchell,Paul, AU - Rochtchina,Elena, AU - Wang,Jie Jin, Y1 - 2006/12/20/ PY - 2006/09/25/received PY - 2006/11/09/revised PY - 2006/11/14/accepted PY - 2007/3/28/pubmed PY - 2007/4/20/medline PY - 2007/3/28/entrez SP - 687 EP - 9 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 143 IS - 4 N2 - PURPOSE: To assess the association between statin use and long-term incident cataract. DESIGN: Population-based cohort study. METHODS: Of 3,654 baseline (1992 to 1994) elderly participants in the Blue Mountains Eye Study (BMES), 2,335 (75% of survivors) were reexamined after five years (1997 to 1999) and 1,952 (76% of survivors) after 10 years (2002 to 2004). Lens photographs were taken and graded using the Wisconsin Cataract Grading System. History, physical examination, and fasting blood samples provided data on possible risk factors. Discrete linear logistic models were used to assess the risk of cataract. RESULTS: After controlling for age, gender, and other factors, statin use was protective for any cataract (hazard ratio [HR] 0.52; 95% confidence interval [CI] 0.29-0.93), but was not significantly associated with incident nuclear (HR 0.66; CI 0.35 to 1.25), cortical (HR 0.76; CI 0.44 to 1.33), or posterior subcapsular (PSC) cataract (HR 1.47; CI 0.70 to 3.08). CONCLUSIONS: Statin use was found to reduce by 50% the risk of cataract development, principally nuclear or cortical cataract subtypes. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/17386279/Statin_use_and_the_long_term_risk_of_incident_cataract:_the_Blue_Mountains_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(06)01312-2 DB - PRIME DP - Unbound Medicine ER -