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Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients.
Am J Hypertens 2007; 20(4):392-7AJ

Abstract

BACKGROUND

Essential hypertension is characterized by endothelial dysfunction, arterial stiffness, and increased oxidative stress. We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients.

METHODS

A randomized, double-blind, placebo-controlled, crossover study design was used to assign 30 male essential hypertensive patients to either vitamin C (1 g) and vitamin E (400 IU) or placebo for 8 weeks. Endothelium-dependent response was assessed as flow-mediated dilation (FMD) of the brachial artery. Arterial stiffness was assessed as central pulse wave velocity (PWV) and augmentation index (AIx). Plasma markers of oxidative stress and antioxidant status were measured.

RESULTS

After vitamin supplementation, FMD was significantly improved. Central PWV was significantly reduced, while AIx tended to decrease. Plasma vitamin levels and antioxidant capacity increased significantly. Levels of oxidative stress decreased. Changes in central PWV were related to changes in levels of oxidative stress.

CONCLUSIONS

Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients. This effect is associated with changes in plasma markers of oxidative stress.

Authors+Show Affiliations

Department of Internal Medicine, University of Pisa, Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17386345

Citation

Plantinga, Yvonne, et al. "Supplementation With Vitamins C and E Improves Arterial Stiffness and Endothelial Function in Essential Hypertensive Patients." American Journal of Hypertension, vol. 20, no. 4, 2007, pp. 392-7.
Plantinga Y, Ghiadoni L, Magagna A, et al. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. 2007;20(4):392-7.
Plantinga, Y., Ghiadoni, L., Magagna, A., Giannarelli, C., Franzoni, F., Taddei, S., & Salvetti, A. (2007). Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. American Journal of Hypertension, 20(4), pp. 392-7.
Plantinga Y, et al. Supplementation With Vitamins C and E Improves Arterial Stiffness and Endothelial Function in Essential Hypertensive Patients. Am J Hypertens. 2007;20(4):392-7. PubMed PMID: 17386345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. AU - Plantinga,Yvonne, AU - Ghiadoni,Lorenzo, AU - Magagna,Armando, AU - Giannarelli,Chiara, AU - Franzoni,Ferdinando, AU - Taddei,Stefano, AU - Salvetti,Antonio, PY - 2006/06/23/received PY - 2006/09/25/revised PY - 2006/09/26/accepted PY - 2007/3/28/pubmed PY - 2007/6/1/medline PY - 2007/3/28/entrez SP - 392 EP - 7 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 20 IS - 4 N2 - BACKGROUND: Essential hypertension is characterized by endothelial dysfunction, arterial stiffness, and increased oxidative stress. We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients. METHODS: A randomized, double-blind, placebo-controlled, crossover study design was used to assign 30 male essential hypertensive patients to either vitamin C (1 g) and vitamin E (400 IU) or placebo for 8 weeks. Endothelium-dependent response was assessed as flow-mediated dilation (FMD) of the brachial artery. Arterial stiffness was assessed as central pulse wave velocity (PWV) and augmentation index (AIx). Plasma markers of oxidative stress and antioxidant status were measured. RESULTS: After vitamin supplementation, FMD was significantly improved. Central PWV was significantly reduced, while AIx tended to decrease. Plasma vitamin levels and antioxidant capacity increased significantly. Levels of oxidative stress decreased. Changes in central PWV were related to changes in levels of oxidative stress. CONCLUSIONS: Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients. This effect is associated with changes in plasma markers of oxidative stress. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/17386345/Supplementation_with_vitamins_C_and_E_improves_arterial_stiffness_and_endothelial_function_in_essential_hypertensive_patients_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.09.021 DB - PRIME DP - Unbound Medicine ER -