TY - JOUR T1 - Determination of acrylamide in food by solid-phase microextraction coupled to gas chromatography-positive chemical ionization tandem mass spectrometry. AU - Lee,Maw-Rong, AU - Chang,Li-Yo, AU - Dou,Jianpeng, Y1 - 2006/08/26/ PY - 2006/06/17/received PY - 2006/08/21/revised PY - 2006/08/22/accepted PY - 2007/3/28/pubmed PY - 2007/6/1/medline PY - 2007/3/28/entrez SP - 19 EP - 23 JF - Analytica chimica acta JO - Anal Chim Acta VL - 582 IS - 1 N2 - A method has been developed to determine acrylamide in aqueous matrices by using direct immersion solid-phase microextraction (SPME) coupled to gas chromatography-positive chemical ionization tandem mass spectrometry (GC-PCI-MS-MS) in the selected reaction monitoring (SRM) mode. The optimized SPME experimental procedures to extract acrylamide in water solutions were: use of a carbowax/divinylbenzene (CW/DVB)-coated fiber at pH 7, extraction time of 20 min and analyte desorption at 210 degrees C for 3 min. A detection limit of 0.1 microg L(-1) was obtained. The linear range was 1-1000 microg L(-1). The relative standard deviation was 10.64% (n=7). The proposed analytical method was successfully used for the quantification of trace acrylamide in foodstuffs such as French fries (1.2 microg g(-1)) and potato crisps (2.2 microg g(-1)). SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/17386469/Determination_of_acrylamide_in_food_by_solid_phase_microextraction_coupled_to_gas_chromatography_positive_chemical_ionization_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(06)01819-8 DB - PRIME DP - Unbound Medicine ER -