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The coupling of solid-phase microextraction/surface enhanced laser desorption/ionization to ion mobility spectrometry for drug analysis.
Anal Chim Acta. 2007 Jan 16; 582(1):50-4.AC

Abstract

The construction of a new solid-phase microextraction/surfaced enhanced laser desorption/ionization-ion mobility spectrometry (SPME/SELDI-IMS) device is reported here. A polypyrrole (PPY) coated SPME/SELDI fiber was employed as the extraction phase and SELDI surface to introduce analytes into the IMS. Analytes were directly ionized from the PPY coated fiber tip by a Nd:YAG laser without the addition of a matrix. Optimal experimental parameters, such as extraction conditions and laser parameters, were investigated. The use of a SPME/SELDI fiber simplified the sampling and sample preparation for IMS. Verapamil could be directly extracted from urine sample and analyzed by IMS without any further sample cleanup. This technique could be used for the analysis of drugs and other non-volatile compounds.

Authors+Show Affiliations

Department of Chemistry, University of Waterloo, Waterloo, Ont., Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17386473

Citation

Wang, Yan, et al. "The Coupling of Solid-phase Microextraction/surface Enhanced Laser Desorption/ionization to Ion Mobility Spectrometry for Drug Analysis." Analytica Chimica Acta, vol. 582, no. 1, 2007, pp. 50-4.
Wang Y, Nacson S, Pawliszyn J. The coupling of solid-phase microextraction/surface enhanced laser desorption/ionization to ion mobility spectrometry for drug analysis. Anal Chim Acta. 2007;582(1):50-4.
Wang, Y., Nacson, S., & Pawliszyn, J. (2007). The coupling of solid-phase microextraction/surface enhanced laser desorption/ionization to ion mobility spectrometry for drug analysis. Analytica Chimica Acta, 582(1), 50-4.
Wang Y, Nacson S, Pawliszyn J. The Coupling of Solid-phase Microextraction/surface Enhanced Laser Desorption/ionization to Ion Mobility Spectrometry for Drug Analysis. Anal Chim Acta. 2007 Jan 16;582(1):50-4. PubMed PMID: 17386473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The coupling of solid-phase microextraction/surface enhanced laser desorption/ionization to ion mobility spectrometry for drug analysis. AU - Wang,Yan, AU - Nacson,Sabatino, AU - Pawliszyn,Janusz, Y1 - 2006/08/30/ PY - 2006/05/13/received PY - 2006/08/14/revised PY - 2006/08/23/accepted PY - 2007/3/28/pubmed PY - 2007/6/1/medline PY - 2007/3/28/entrez SP - 50 EP - 4 JF - Analytica chimica acta JO - Anal. Chim. Acta VL - 582 IS - 1 N2 - The construction of a new solid-phase microextraction/surfaced enhanced laser desorption/ionization-ion mobility spectrometry (SPME/SELDI-IMS) device is reported here. A polypyrrole (PPY) coated SPME/SELDI fiber was employed as the extraction phase and SELDI surface to introduce analytes into the IMS. Analytes were directly ionized from the PPY coated fiber tip by a Nd:YAG laser without the addition of a matrix. Optimal experimental parameters, such as extraction conditions and laser parameters, were investigated. The use of a SPME/SELDI fiber simplified the sampling and sample preparation for IMS. Verapamil could be directly extracted from urine sample and analyzed by IMS without any further sample cleanup. This technique could be used for the analysis of drugs and other non-volatile compounds. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/17386473/The_coupling_of_solid_phase_microextraction/surface_enhanced_laser_desorption/ionization_to_ion_mobility_spectrometry_for_drug_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(06)01824-1 DB - PRIME DP - Unbound Medicine ER -