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MDMA attenuates THC withdrawal syndrome in mice.
Psychopharmacology (Berl) 2007; 193(1):75-84P

Abstract

INTRODUCTION

3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses observed in animals, such as body temperature, anxiety, cognition, and reward. However, the interaction between MDMA and cannabis in addictive processes such as physical dependence has not been elucidated yet.

DISCUSSION

In this study, the effects of acute and chronic MDMA were evaluated on the behavioral manifestations of Delta(9)-tetrahydrocannabinol (THC) abstinence in mice. THC withdrawal syndrome was precipitated by injecting the cannabinoid antagonist rimonabant (10 mg/kg, i.p.) in mice chronically treated with THC and receiving MDMA (2.5, 5 and 10 mg/kg i.p.) or saline just before the withdrawal induction or chronically after the THC administration.

RESULTS

Both chronic and acute MDMA decreased in a dose-dependent manner the severity of THC withdrawal. In vivo microdialysis experiments showed that acute MDMA (5 mg/kg, i.p.) administration increased extracellular serotonin levels in the prefrontal cortex, but not dopamine levels in the nucleus accumbens. Our results also indicate that the attenuation of THC abstinence symptoms was not due to a direct interaction between rimonabant and MDMA nor to the result of the locomotor stimulating effects of MDMA.

CONCLUSION

The modulation of the cannabinoid withdrawal syndrome by acute or chronic MDMA suggests a possible mechanism to explain the associated consumption of these two drugs in humans.

Authors+Show Affiliations

Grup de Recerca de Neurobiologia del Comportament, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, C/ Dr. Aiguader 80, 08003, Barcelona, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17387458

Citation

Touriño, Clara, et al. "MDMA Attenuates THC Withdrawal Syndrome in Mice." Psychopharmacology, vol. 193, no. 1, 2007, pp. 75-84.
Touriño C, Maldonado R, Valverde O. MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology (Berl). 2007;193(1):75-84.
Touriño, C., Maldonado, R., & Valverde, O. (2007). MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology, 193(1), pp. 75-84.
Touriño C, Maldonado R, Valverde O. MDMA Attenuates THC Withdrawal Syndrome in Mice. Psychopharmacology (Berl). 2007;193(1):75-84. PubMed PMID: 17387458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDMA attenuates THC withdrawal syndrome in mice. AU - Touriño,Clara, AU - Maldonado,Rafael, AU - Valverde,Olga, Y1 - 2007/03/27/ PY - 2006/09/29/received PY - 2007/03/10/accepted PY - 2007/3/28/pubmed PY - 2007/9/7/medline PY - 2007/3/28/entrez SP - 75 EP - 84 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 193 IS - 1 N2 - INTRODUCTION: 3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses observed in animals, such as body temperature, anxiety, cognition, and reward. However, the interaction between MDMA and cannabis in addictive processes such as physical dependence has not been elucidated yet. DISCUSSION: In this study, the effects of acute and chronic MDMA were evaluated on the behavioral manifestations of Delta(9)-tetrahydrocannabinol (THC) abstinence in mice. THC withdrawal syndrome was precipitated by injecting the cannabinoid antagonist rimonabant (10 mg/kg, i.p.) in mice chronically treated with THC and receiving MDMA (2.5, 5 and 10 mg/kg i.p.) or saline just before the withdrawal induction or chronically after the THC administration. RESULTS: Both chronic and acute MDMA decreased in a dose-dependent manner the severity of THC withdrawal. In vivo microdialysis experiments showed that acute MDMA (5 mg/kg, i.p.) administration increased extracellular serotonin levels in the prefrontal cortex, but not dopamine levels in the nucleus accumbens. Our results also indicate that the attenuation of THC abstinence symptoms was not due to a direct interaction between rimonabant and MDMA nor to the result of the locomotor stimulating effects of MDMA. CONCLUSION: The modulation of the cannabinoid withdrawal syndrome by acute or chronic MDMA suggests a possible mechanism to explain the associated consumption of these two drugs in humans. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/17387458/MDMA_attenuates_THC_withdrawal_syndrome_in_mice_ L2 - https://dx.doi.org/10.1007/s00213-007-0772-5 DB - PRIME DP - Unbound Medicine ER -