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Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity.
Pflugers Arch. 2007 Jul; 454(4):551-7.PA

Abstract

We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) mediated cardiac sympathetic afferent reflex (CSAR). The present study investigated the role of endogenous hydrogen peroxide (H(2)O(2)), a ROS, in the PVN in mediating the CSAR and regulating sympathetic activity. The CSAR was evaluated by the response of renal sympathetic nerve activity (RSNA) to epicardial application of bradykinin (BK) in rats. Bilateral microinjection of polyethylene glycol-catalase (PEG-CAT, an analogue of endogenous catalase) or polyethylene glycol-superoxide dismutase (PEG-SOD, an analogue of endogenous superoxide dismutase) into the PVN abolished the CSAR, decreased baseline RSNA and mean arterial pressure (MAP). Moreover, pretreatment with PEG-CAT or PEG-SOD blocked the enhanced CSAR and RSNA responses induced by exogenous angiotensin II (Ang II) in the PVN. Aminotriazole (ATZ, a catalase inhibitor) alone potentiated the CSAR, increased RSNA and MAP, but failed to augment the Ang II-induced CSAR enhancement responses. Pretreated with PEG-SOD, ATZ still increased baseline RSNA and MAP but inhibited the CSAR and Ang II-induced CSAR and RSNA enhancement responses. These results suggested that endogenous H(2)O(2) in the PVN mediated both the CSAR and Ang II-induced CSAR enhancement responses. H(2)O(2) in the PVN were involved in regulating sympathetic activity and arterial pressure.

Authors+Show Affiliations

Department of Physiology, Nanjing Medical University, Nanjing 210029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17387509

Citation

Yu, Yang, et al. "Endogenous Hydrogen Peroxide in Paraventricular Nucleus Mediating Cardiac Sympathetic Afferent Reflex and Regulating Sympathetic Activity." Pflugers Archiv : European Journal of Physiology, vol. 454, no. 4, 2007, pp. 551-7.
Yu Y, Zhong MK, Li J, et al. Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Arch. 2007;454(4):551-7.
Yu, Y., Zhong, M. K., Li, J., Sun, X. L., Xie, G. Q., Wang, W., & Zhu, G. Q. (2007). Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Archiv : European Journal of Physiology, 454(4), 551-7.
Yu Y, et al. Endogenous Hydrogen Peroxide in Paraventricular Nucleus Mediating Cardiac Sympathetic Afferent Reflex and Regulating Sympathetic Activity. Pflugers Arch. 2007;454(4):551-7. PubMed PMID: 17387509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. AU - Yu,Yang, AU - Zhong,Ming-Kui, AU - Li,Jing, AU - Sun,Xiu-Lan, AU - Xie,Gui-Qing, AU - Wang,Wei, AU - Zhu,Guo-Qing, Y1 - 2007/03/27/ PY - 2007/01/29/received PY - 2007/03/13/accepted PY - 2007/03/01/revised PY - 2007/3/28/pubmed PY - 2007/9/28/medline PY - 2007/3/28/entrez SP - 551 EP - 7 JF - Pflugers Archiv : European journal of physiology JO - Pflugers Arch. VL - 454 IS - 4 N2 - We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) mediated cardiac sympathetic afferent reflex (CSAR). The present study investigated the role of endogenous hydrogen peroxide (H(2)O(2)), a ROS, in the PVN in mediating the CSAR and regulating sympathetic activity. The CSAR was evaluated by the response of renal sympathetic nerve activity (RSNA) to epicardial application of bradykinin (BK) in rats. Bilateral microinjection of polyethylene glycol-catalase (PEG-CAT, an analogue of endogenous catalase) or polyethylene glycol-superoxide dismutase (PEG-SOD, an analogue of endogenous superoxide dismutase) into the PVN abolished the CSAR, decreased baseline RSNA and mean arterial pressure (MAP). Moreover, pretreatment with PEG-CAT or PEG-SOD blocked the enhanced CSAR and RSNA responses induced by exogenous angiotensin II (Ang II) in the PVN. Aminotriazole (ATZ, a catalase inhibitor) alone potentiated the CSAR, increased RSNA and MAP, but failed to augment the Ang II-induced CSAR enhancement responses. Pretreated with PEG-SOD, ATZ still increased baseline RSNA and MAP but inhibited the CSAR and Ang II-induced CSAR and RSNA enhancement responses. These results suggested that endogenous H(2)O(2) in the PVN mediated both the CSAR and Ang II-induced CSAR enhancement responses. H(2)O(2) in the PVN were involved in regulating sympathetic activity and arterial pressure. SN - 0031-6768 UR - https://www.unboundmedicine.com/medline/citation/17387509/Endogenous_hydrogen_peroxide_in_paraventricular_nucleus_mediating_cardiac_sympathetic_afferent_reflex_and_regulating_sympathetic_activity_ L2 - https://dx.doi.org/10.1007/s00424-007-0256-9 DB - PRIME DP - Unbound Medicine ER -