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Apolipoprotein modifying effects of statins and fibrate in various age groups of coronary artery disease patients.
J Indian Med Assoc. 2006 Sep; 104(9):492-4, 496, 498.JI

Abstract

These days apolipoproteins especially apo B and apo A I are thought to be better predictors of risk of coronary artery disease as compared to lipids and lipoprotein cholesterol. Lifestyle modification and use of lipid modifying drugs such as statins and fibrates have proven effective in reducing the risk of coronary artery disease. Statins and fibrates are known to possess anti-atherosclerotic properties in addition to lipid modifying effects. Extensive data is available regarding lipid modification especially lowering of low density lipoprotein-cholesterol levels by these drugs. But the data regarding the effect of statins and fibrates, on apolipoprotein levels is scanty. Hence the present study was aimed at assessing the effect of statins (atorvastatin, simvastatin) and fenofibrate on serum apo B and apo A I levels in addition to their lipid modifying effects in various age groups of coronary artery disease patients. One hundred patients suffering from coronary artery disease were randomly assigned to 10 mg atorvastatin, 10 mg simvastatin and 200 mg fenofibrate, separately (without any combination). All the patients were divided into three age groups; group I (35-45 years), group II (46-55 years) and group III (> 55 years). Significant modification was observed in lipid and lipoprotein profile of coronary artery disease patients when treated with these drugs (statins and fibrates). A significant increase in serum apo A I (p < 0.01) and decline in serum apo B levels (p < 0.01) was observed in case of coronary artery disease patients after 16 weeks treatment, though the effect started after 1 month. All the three drugs reduced serum apo B levels in a comparable manner. Fenofibrate increased serum high density lipoprotein-cholesterol and apo A I levels more as compared to statins. It had nearly, proportionate effect in increasing high density lipoprotein-cholesterol and apo A I levels and reducing serum low density lipoprotein-cholesterol and apo B levels while the effect was disproportionate in case of atorvastatin and simvastatin. All the three drugs not only corrected lipid and lipoprotein cholesterol levels but also modified, apolipoprotein levels in a positive direction in coronary artery disease patients. Advancing age had no appreciable effect on the efficacy of these drugs.

Authors+Show Affiliations

ICMR, Department of Biochemistry and Molecular Biology, Guru Nanak Dev University, Amritsar.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17388006

Citation

Sharma, Ritu, et al. "Apolipoprotein Modifying Effects of Statins and Fibrate in Various Age Groups of Coronary Artery Disease Patients." Journal of the Indian Medical Association, vol. 104, no. 9, 2006, pp. 492-4, 496, 498.
Sharma R, Mahajan M, Singh B, et al. Apolipoprotein modifying effects of statins and fibrate in various age groups of coronary artery disease patients. J Indian Med Assoc. 2006;104(9):492-4, 496, 498.
Sharma, R., Mahajan, M., Singh, B., Bal, B. S., & Kant, R. (2006). Apolipoprotein modifying effects of statins and fibrate in various age groups of coronary artery disease patients. Journal of the Indian Medical Association, 104(9), 492-4, 496, 498.
Sharma R, et al. Apolipoprotein Modifying Effects of Statins and Fibrate in Various Age Groups of Coronary Artery Disease Patients. J Indian Med Assoc. 2006;104(9):492-4, 496, 498. PubMed PMID: 17388006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein modifying effects of statins and fibrate in various age groups of coronary artery disease patients. AU - Sharma,Ritu, AU - Mahajan,Mridula, AU - Singh,Balwant, AU - Bal,B S, AU - Kant,Ravi, PY - 2007/3/29/pubmed PY - 2007/4/20/medline PY - 2007/3/29/entrez SP - 492-4, 496, 498 JF - Journal of the Indian Medical Association JO - J Indian Med Assoc VL - 104 IS - 9 N2 - These days apolipoproteins especially apo B and apo A I are thought to be better predictors of risk of coronary artery disease as compared to lipids and lipoprotein cholesterol. Lifestyle modification and use of lipid modifying drugs such as statins and fibrates have proven effective in reducing the risk of coronary artery disease. Statins and fibrates are known to possess anti-atherosclerotic properties in addition to lipid modifying effects. Extensive data is available regarding lipid modification especially lowering of low density lipoprotein-cholesterol levels by these drugs. But the data regarding the effect of statins and fibrates, on apolipoprotein levels is scanty. Hence the present study was aimed at assessing the effect of statins (atorvastatin, simvastatin) and fenofibrate on serum apo B and apo A I levels in addition to their lipid modifying effects in various age groups of coronary artery disease patients. One hundred patients suffering from coronary artery disease were randomly assigned to 10 mg atorvastatin, 10 mg simvastatin and 200 mg fenofibrate, separately (without any combination). All the patients were divided into three age groups; group I (35-45 years), group II (46-55 years) and group III (> 55 years). Significant modification was observed in lipid and lipoprotein profile of coronary artery disease patients when treated with these drugs (statins and fibrates). A significant increase in serum apo A I (p < 0.01) and decline in serum apo B levels (p < 0.01) was observed in case of coronary artery disease patients after 16 weeks treatment, though the effect started after 1 month. All the three drugs reduced serum apo B levels in a comparable manner. Fenofibrate increased serum high density lipoprotein-cholesterol and apo A I levels more as compared to statins. It had nearly, proportionate effect in increasing high density lipoprotein-cholesterol and apo A I levels and reducing serum low density lipoprotein-cholesterol and apo B levels while the effect was disproportionate in case of atorvastatin and simvastatin. All the three drugs not only corrected lipid and lipoprotein cholesterol levels but also modified, apolipoprotein levels in a positive direction in coronary artery disease patients. Advancing age had no appreciable effect on the efficacy of these drugs. SN - 0019-5847 UR - https://www.unboundmedicine.com/medline/citation/17388006/Apolipoprotein_modifying_effects_of_statins_and_fibrate_in_various_age_groups_of_coronary_artery_disease_patients_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -