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A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease.

Abstract

BACKGROUND

High consumption of trans fat has been linked to the risk of coronary heart disease (CHD). We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women.

METHODS AND RESULTS

Blood samples were collected from 32,826 participants of the Nurses' Health Study from 1989 to 1990. During 6 years of follow-up, 166 incident cases of CHD were ascertained and matched with 327 controls. Total trans fatty acid content in erythrocytes was significantly correlated with dietary intake of trans fat (correlation coefficient=0.44, P<0.01) and was associated with increased plasma low-density lipoprotein cholesterol (P for trend =0.06), decreased plasma high-density lipoprotein cholesterol concentrations (P for trend <0.01), and increased plasma low-density lipoprotein to high-density lipoprotein ratio (P for trend <0.01). After adjustment for age, smoking status, and other dietary and lifestyle cardiovascular risk factors, higher total trans fatty acid content in erythrocytes was associated with an elevated risk of CHD. The multivariable relative risks (95% confidence intervals) of CHD from the lowest to highest quartiles of total trans fatty acid content in erythrocytes were 1.0 (reference), 1.6 (0.7 to 3.6), 1.6 (0.7 to 3.4), and 3.3 (1.5 to 7.2) (P for trend <0.01). The corresponding relative risks were 1.0, 1.1, 1.3, and 3.1 (P for trend <0.01) for a total of 18:1 trans isomers and 1.0, 1.5, 2.5, and 2.8 (P for trend <0.01) for a total of 18:2 trans isomers.

CONCLUSIONS

These biomarker data provide further evidence that high trans fat consumption remains a significant risk factor for CHD after adjustment for covariates.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.

    , , , , , , ,

    Source

    Circulation 115:14 2007 Apr 10 pg 1858-65

    MeSH

    Adult
    Alcohol Drinking
    Case-Control Studies
    Cholesterol, HDL
    Cholesterol, LDL
    Dietary Fats
    Erythrocytes
    Female
    Follow-Up Studies
    Humans
    Life Style
    Middle Aged
    Myocardial Infarction
    Prospective Studies
    Risk
    Risk Factors
    Single-Blind Method
    Smoking
    Surveys and Questionnaires
    Trans Fatty Acids
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17389261

    Citation

    Sun, Qi, et al. "A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease." Circulation, vol. 115, no. 14, 2007, pp. 1858-65.
    Sun Q, Ma J, Campos H, et al. A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation. 2007;115(14):1858-65.
    Sun, Q., Ma, J., Campos, H., Hankinson, S. E., Manson, J. E., Stampfer, M. J., ... Hu, F. B. (2007). A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation, 115(14), pp. 1858-65.
    Sun Q, et al. A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease. Circulation. 2007 Apr 10;115(14):1858-65. PubMed PMID: 17389261.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. AU - Sun,Qi, AU - Ma,Jing, AU - Campos,Hannia, AU - Hankinson,Susan E, AU - Manson,JoAnn E, AU - Stampfer,Meir J, AU - Rexrode,Kathryn M, AU - Willett,Walter C, AU - Hu,Frank B, Y1 - 2007/03/26/ PY - 2007/3/29/pubmed PY - 2007/5/8/medline PY - 2007/3/29/entrez SP - 1858 EP - 65 JF - Circulation JO - Circulation VL - 115 IS - 14 N2 - BACKGROUND: High consumption of trans fat has been linked to the risk of coronary heart disease (CHD). We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women. METHODS AND RESULTS: Blood samples were collected from 32,826 participants of the Nurses' Health Study from 1989 to 1990. During 6 years of follow-up, 166 incident cases of CHD were ascertained and matched with 327 controls. Total trans fatty acid content in erythrocytes was significantly correlated with dietary intake of trans fat (correlation coefficient=0.44, P<0.01) and was associated with increased plasma low-density lipoprotein cholesterol (P for trend =0.06), decreased plasma high-density lipoprotein cholesterol concentrations (P for trend <0.01), and increased plasma low-density lipoprotein to high-density lipoprotein ratio (P for trend <0.01). After adjustment for age, smoking status, and other dietary and lifestyle cardiovascular risk factors, higher total trans fatty acid content in erythrocytes was associated with an elevated risk of CHD. The multivariable relative risks (95% confidence intervals) of CHD from the lowest to highest quartiles of total trans fatty acid content in erythrocytes were 1.0 (reference), 1.6 (0.7 to 3.6), 1.6 (0.7 to 3.4), and 3.3 (1.5 to 7.2) (P for trend <0.01). The corresponding relative risks were 1.0, 1.1, 1.3, and 3.1 (P for trend <0.01) for a total of 18:1 trans isomers and 1.0, 1.5, 2.5, and 2.8 (P for trend <0.01) for a total of 18:2 trans isomers. CONCLUSIONS: These biomarker data provide further evidence that high trans fat consumption remains a significant risk factor for CHD after adjustment for covariates. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17389261/A_prospective_study_of_trans_fatty_acids_in_erythrocytes_and_risk_of_coronary_heart_disease_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.106.679985?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -