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Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study.
Circulation. 2007 Mar 27; 115(12):1537-43.Circ

Abstract

BACKGROUND

Adipocyte-fatty acid binding protein (A-FABP), a major cytoplasmic protein in adipocytes, plays a central role in the development of diabetes and atherosclerotic cardiovascular disease in experimental animals. We have previously shown that A-FABP is present in the bloodstream and that its circulating levels correlate with metabolic risk factors in a cross-sectional study. In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria.

METHODS AND RESULTS

In the present study, 495 nondiabetic adults from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study were prospectively followed up for 5 years. The relationship of serum A-FABP with the MetS and its components was investigated. At baseline, high A-FABP levels were associated with the MetS (odds ratio, 4.0; 95% CI, 1.5 to 10.4; highest versus lowest sex-specific tertile, adjusted for age, body mass index, the homeostasis model assessment index for insulin resistance, C-reactive protein, and adiponectin, P=0.005). On long-term follow-up, subjects with higher baseline A-FABP levels had progressively worse cardiometabolic risk profile and increasing risk of the MetS. Among 376 subjects without the MetS at baseline, 50 had developed it at 5 years. Apart from the homeostasis model assessment index for insulin resistance (P=0.001), baseline A-FABP was the only independent predictor of the development of the MetS during the 5-year follow-up (odds ratio, 4.7; 95% CI, 1.8 to 11.9; highest versus lowest sex-specific tertile, P=0.001, adjusted for the homeostasis model assessment index for insulin resistance and body mass index). A-FABP was predictive of the MetS even after adjustment for each of its individual components.

CONCLUSIONS

Circulating A-FABP predicts the development of the MetS independently of adiposity and insulin resistance.

Authors+Show Affiliations

Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17389279

Citation

Xu, Aimin, et al. "Circulating Adipocyte-fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome: a 5-year Prospective Study." Circulation, vol. 115, no. 12, 2007, pp. 1537-43.
Xu A, Tso AW, Cheung BM, et al. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 2007;115(12):1537-43.
Xu, A., Tso, A. W., Cheung, B. M., Wang, Y., Wat, N. M., Fong, C. H., Yeung, D. C., Janus, E. D., Sham, P. C., & Lam, K. S. (2007). Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation, 115(12), 1537-43.
Xu A, et al. Circulating Adipocyte-fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome: a 5-year Prospective Study. Circulation. 2007 Mar 27;115(12):1537-43. PubMed PMID: 17389279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. AU - Xu,Aimin, AU - Tso,Annette W K, AU - Cheung,Bernard M Y, AU - Wang,Yu, AU - Wat,Nelson M S, AU - Fong,Carol H Y, AU - Yeung,Dennis C Y, AU - Janus,Edward D, AU - Sham,Pak C, AU - Lam,Karen S L, PY - 2007/3/29/pubmed PY - 2007/5/30/medline PY - 2007/3/29/entrez SP - 1537 EP - 43 JF - Circulation JO - Circulation VL - 115 IS - 12 N2 - BACKGROUND: Adipocyte-fatty acid binding protein (A-FABP), a major cytoplasmic protein in adipocytes, plays a central role in the development of diabetes and atherosclerotic cardiovascular disease in experimental animals. We have previously shown that A-FABP is present in the bloodstream and that its circulating levels correlate with metabolic risk factors in a cross-sectional study. In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria. METHODS AND RESULTS: In the present study, 495 nondiabetic adults from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study were prospectively followed up for 5 years. The relationship of serum A-FABP with the MetS and its components was investigated. At baseline, high A-FABP levels were associated with the MetS (odds ratio, 4.0; 95% CI, 1.5 to 10.4; highest versus lowest sex-specific tertile, adjusted for age, body mass index, the homeostasis model assessment index for insulin resistance, C-reactive protein, and adiponectin, P=0.005). On long-term follow-up, subjects with higher baseline A-FABP levels had progressively worse cardiometabolic risk profile and increasing risk of the MetS. Among 376 subjects without the MetS at baseline, 50 had developed it at 5 years. Apart from the homeostasis model assessment index for insulin resistance (P=0.001), baseline A-FABP was the only independent predictor of the development of the MetS during the 5-year follow-up (odds ratio, 4.7; 95% CI, 1.8 to 11.9; highest versus lowest sex-specific tertile, P=0.001, adjusted for the homeostasis model assessment index for insulin resistance and body mass index). A-FABP was predictive of the MetS even after adjustment for each of its individual components. CONCLUSIONS: Circulating A-FABP predicts the development of the MetS independently of adiposity and insulin resistance. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17389279/Circulating_adipocyte_fatty_acid_binding_protein_levels_predict_the_development_of_the_metabolic_syndrome:_a_5_year_prospective_study_ L2 - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.647503?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -