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Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis.
Neurology. 2007 Mar 27; 68(13):1045-50.Neur

Abstract

OBJECTIVE

To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity.

METHODS

We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity.

RESULTS

A single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation.

CONCLUSIONS

Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis.

Authors+Show Affiliations

Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, Italy. centonze@uniroma2.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17389310

Citation

Centonze, D, et al. "Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Ameliorates Spasticity in Multiple Sclerosis." Neurology, vol. 68, no. 13, 2007, pp. 1045-50.
Centonze D, Koch G, Versace V, et al. Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. Neurology. 2007;68(13):1045-50.
Centonze, D., Koch, G., Versace, V., Mori, F., Rossi, S., Brusa, L., Grossi, K., Torelli, F., Prosperetti, C., Cervellino, A., Marfia, G. A., Stanzione, P., Marciani, M. G., Boffa, L., & Bernardi, G. (2007). Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. Neurology, 68(13), 1045-50.
Centonze D, et al. Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Ameliorates Spasticity in Multiple Sclerosis. Neurology. 2007 Mar 27;68(13):1045-50. PubMed PMID: 17389310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. AU - Centonze,D, AU - Koch,G, AU - Versace,V, AU - Mori,F, AU - Rossi,S, AU - Brusa,L, AU - Grossi,K, AU - Torelli,F, AU - Prosperetti,C, AU - Cervellino,A, AU - Marfia,G A, AU - Stanzione,P, AU - Marciani,M G, AU - Boffa,L, AU - Bernardi,G, PY - 2007/3/29/pubmed PY - 2007/4/26/medline PY - 2007/3/29/entrez SP - 1045 EP - 50 JF - Neurology JO - Neurology VL - 68 IS - 13 N2 - OBJECTIVE: To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS: We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS: A single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation. CONCLUSIONS: Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17389310/Repetitive_transcranial_magnetic_stimulation_of_the_motor_cortex_ameliorates_spasticity_in_multiple_sclerosis_ DB - PRIME DP - Unbound Medicine ER -