Citation
Centonze, D, et al. "Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Ameliorates Spasticity in Multiple Sclerosis." Neurology, vol. 68, no. 13, 2007, pp. 1045-50.
Centonze D, Koch G, Versace V, et al. Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. Neurology. 2007;68(13):1045-50.
Centonze, D., Koch, G., Versace, V., Mori, F., Rossi, S., Brusa, L., Grossi, K., Torelli, F., Prosperetti, C., Cervellino, A., Marfia, G. A., Stanzione, P., Marciani, M. G., Boffa, L., & Bernardi, G. (2007). Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. Neurology, 68(13), 1045-50.
Centonze D, et al. Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Ameliorates Spasticity in Multiple Sclerosis. Neurology. 2007 Mar 27;68(13):1045-50. PubMed PMID: 17389310.
TY - JOUR
T1 - Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis.
AU - Centonze,D,
AU - Koch,G,
AU - Versace,V,
AU - Mori,F,
AU - Rossi,S,
AU - Brusa,L,
AU - Grossi,K,
AU - Torelli,F,
AU - Prosperetti,C,
AU - Cervellino,A,
AU - Marfia,G A,
AU - Stanzione,P,
AU - Marciani,M G,
AU - Boffa,L,
AU - Bernardi,G,
PY - 2007/3/29/pubmed
PY - 2007/4/26/medline
PY - 2007/3/29/entrez
SP - 1045
EP - 50
JF - Neurology
JO - Neurology
VL - 68
IS - 13
N2 - OBJECTIVE: To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS: We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS: A single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation. CONCLUSIONS: Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis.
SN - 1526-632X
UR - https://www.unboundmedicine.com/medline/citation/17389310/Repetitive_transcranial_magnetic_stimulation_of_the_motor_cortex_ameliorates_spasticity_in_multiple_sclerosis_
DB - PRIME
DP - Unbound Medicine
ER -